Development of Stable, Water-Dispersible, and Biofunctionalizable Superparamagnetic Iron Oxide Nanoparticles

Miguel-Sancho, Nuria; Bomatí-Miguel, O.; Colom, Gloria; Salvador, J.‐Pablo; Marco, M.‐Pilar; Santamarı́a, Jesús

doi:10.1021/cm1036452

Cited by 86 publications

(71 citation statements)

References 34 publications

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“…When the temperature of the mixture is near to 180°C, the color of the solution changes continuously from dark red to black, indicating the decomposition of the iron complexes and the nuclei formation in the solution. The further increasing of the temperature above 180°C, enhancesthe monomer diffusion over the surface of the nanoparticles, increasing the growth rate, and also upgrading the crystallinity of the particles [24,25].…”

Section: Resultsmentioning

confidence: 99%

“…Other works studying the characteristics of the obtained nanoparticles were reported after the work of Cai and Wan [21][22][23][24][25][26]. MiguelSancho et al [24] discussed the stability of nanoparticles in relation with agglomeration process by using either dimercaptosuccinicacid (DMSA) or chemical modification of TEG coating. In a more recent paper, Miguel-Sancho et al [25] showed the influence of some experimental parameters on particle size, as initial precursor concentration, decomposition time and heating rate.…”

Section: Introductionmentioning

confidence: 99%

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Influence of synthesis experimental parameters on the formation of magnetite nanoparticles prepared by polyol method

Vega-Chacón

Picasso

Avilés-Félix

et al. 2016

Adv. Nat. Sci: Nanosci. Nanotechnol.

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In this paper we present a modified polyol method for synthesizing magnetite nanoparticles using iron (III) nitrate, a low toxic and cheap precursor salt. The influence of the precursor salt nature and initial ferric concentration in the average particle size and magnetic properties of the obtained nanoparticles were investigated. Magnetite nanoparticles have received much attention due to the multiple uses in the biomedical field; for these purposes nanoparticles with monodisperse size distribution, superparamagnetic behavior and a combination between small average size and high saturation magnetization are required. The polyol conventional method allows synthesizing water-dispersible magnetite nanoparticles with these features employing iron (III) acetylacetonate as precursor salt. Although the particle sizes of samples synthesized from the conventional polyol method (denoted CM) are larger than those of samples synthesized from the modified method (denoted MM), they display similar saturation magnetization. The differences in the nanoparticles average sizes of samples CM and samples MM were explained though the known nanoparticle formation mechanism.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of synthesis experimental parameters on the formation of magnetite nanoparticles prepared by polyol method

Vega-Chacón

Picasso

Avilés-Félix

et al. 2016

Adv. Nat. Sci: Nanosci. Nanotechnol.

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“…superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized by a polyol-mediated method according to the synthesis procedure described elsewhere. [26][27] DMSA-FexOy nanoparticles were obtained via a ligand-exchange reaction process described in a previous work of our laboratory 28 The synthesis conditions were tailored to obtain SPION nanoparticles larger than the silica pores. Briefly, a DMSA aqueous solution (30 mg mL -1 ) was strongly mixed with a TEGcoated-SPIONs aqueous solution at room temperature.…”

Section: Introductionmentioning

confidence: 99%

“…28 DMSA is able to form a stable covalent bond with the surface of the FexOy nanoparticles using one of the available carboxylic groups (COOH).…”

Section: Introductionmentioning

confidence: 99%

Pumping Metallic Nanoparticles with Spatial Precision within Magnetic Mesoporous Platforms: 3D Characterization and Catalytic Application

Miguel-Sancho

Martı́nez

Sebastián

et al. 2017

ACS Appl. Mater. Interfaces

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┴ Araid Foundation. KEYWORDSRecyclable, magnetically recoverable self-assembled structures, mesoporous silica, waterdispersible nanoparticles, magnetic properties, peptide-like bonding and hydrogenation. ABSTRACTThe present work shows an efficient strategy to assemble two types of functional nanoparticles onto mesoporous MCM-41 silica nanospheres with high degree of spatial precision. In a first stage, magnetite nanoparticles are synthesized with a size larger than the support pores and grafted covalently through a peptide-like bonding onto its external surface. This endowed the silica nanoparticles with a strong superparamagnetic response, while preserving the highly ordered interior space for the encapsulation of other functional guest species. Secondly, we report the finely controlled pumping of preformed Pt nanoparticles (1.5 nm) within the channels of the magnetic MCM-41 nanospheres to confer an additional catalytic functionality to the multi-assembled nanoplatform. The penetration depth of the metallic nanoparticles can be explained as a result of the interplay between particle-wall electrostatic attraction and the repulsive forces between neighbouring Pt nanoparticles. A detailed transmission electron microscopy (TEM) and 3-D HighResolution HAADF electron Tomography study was carried out to characterize the material and to explain the assembly mechanism. Finally, the performance of these multifunctional nanohybrids as magnetically recoverable catalysts has been evaluated in the selective hydrogenation of pnitrophenol, a well-known pollutant and intermediate in multiple industrial processes.3

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“…nalization 19,20 . Phosphonic acid 21 and carboxylic groups 22 also show a strong affinity for IONPs surfaces by interacting with the surface with a co-ordination process. Dopamine 23 is also important in the attachment of a range of biologically molecules (e.g.…”

Section: Introductionmentioning

confidence: 99%

Amino covalent binding approach on iron oxide nanoparticle surface: Toward biological applications

Griffete

Clift

Lamouri

et al. 2012

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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ABSTRACT:We report on the synthesis and the surface modification of different types of magnetic iron oxide particles by developing an original process based on diazonium salts chemistry. Particles were first coated with amino groups and then subjected to polyethylene glycol (PEG) surface modification. They were subsequently characterized by Transmission electron microscopy, infrared spectroscopy, diffraction light scattering and by Zeta potential. To show the efficiency of this surface modification method, the potential cytotoxicity and (pro-)inflammatory effect of the PEG magnetic particles were also analyzed in vitro. This covalently surface modification approach based on diazonium salts chemistry provides individually dispersed, PEG-modified magnetic nanoparticles suitable for biological applications.

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Development of Stable, Water-Dispersible, and Biofunctionalizable Superparamagnetic Iron Oxide Nanoparticles

Cited by 86 publications

References 34 publications

Influence of synthesis experimental parameters on the formation of magnetite nanoparticles prepared by polyol method

Influence of synthesis experimental parameters on the formation of magnetite nanoparticles prepared by polyol method

Pumping Metallic Nanoparticles with Spatial Precision within Magnetic Mesoporous Platforms: 3D Characterization and Catalytic Application

Amino covalent binding approach on iron oxide nanoparticle surface: Toward biological applications

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