Since long, conventional drugs have been utilized in the Indo-Pak subcontinents. The most realized frameworks utilized customarily are Ayurvedic and Unani therapy. Both of these frameworks utilize spices, minerals and creature tissues in various ailments. Kushta is derieved from Persian word 'KUSHTAN' which signifies 'killed or won'. Kushta is a significant class among the compound detailing which is ready by burning endorsed metals, minerals, and creature parts beat and pulverized with suggested measure of plant remove, further exposing it to the traditional cremation strategy utilizing cow manure cakes. Sadaf (Pinctada margaritifera), a marine beginning normal shell in its Kushta structure, is a solution for various issues, shown in heart shortcoming (zouf-e-qalb), leukorrhea (sailan-urrahem), discharge (nazuf-ud-dam), calcium insufficiency (qilat-e-kils), menorrhagia (kasrate-hat), fever in tuberculosis (huma-e-sil-o-diq), asthma (zeeq-un-nafs), ongoing hack (surfae-muzmin), sexual weakness (zouf-e-bah), hemorrhoids (bawasir), and acid reflux (zouf-ehazam). It contains different minerals like calcium, iron, copper and bromide important for the human body. Kushtas are nano-crystals having the size of 1-100 nm and are known for their therapeutic effect. Sadaf (Oyster shell) is the covering of a marine animal. Kushta-e-Sadaf is rich in calcium, iron, and copper and it is used in the treatment of such innumerable major issues like cardiovascular issue, sexual failure, and renal issue. This review covers the methods of preparation of kushta e sadaf and its benefits in medical and non-medical fields.