Development of Strength in Dequalinium Chloride-Treated Skin Incisions in Rat

Abstract

Dequalinium chloride is a quaternary ammonium compound used for the treatment of infected skin and mucosal lesions. Its influence on the healing of incisional wounds in rat skin has been studied by a tensiometric technique. The breaking load was significantly lower in wounds that had been exposed to an aqueous solution of dequalinium chloride than those exposed to distilled water. The concentrations of dequalinium chloride were well below those used in clinical practice. The results obtained from incisional wounds are probably valid also for open wounds. The results are correlated with the microcirculatory disturbances demonstrated in previous studies. This suggests that the use of dequalinium chloride in treating human wounds should be re-evaluated.

From Serendipity to Mitochondria-Targeted Nanocarriers

“…1,1′-Decamethylene bis (4-aminoquinaldiniumchloride), referred to as dequalinium (DQA), has been used for more than 50 years as an antimicrobial agent in over-the-counter mouthwashes, lozenges, ointments, and paints (1,2). Dequalinium is a cationic bolaamphiphile composed of two quinaldinium rings linked by ten methylene groups (Fig.…”

Interference with healing of rat skin incisions treated with chlorhexidine

“…used in this study, where test and control wounds are inflicted simultaneously and symmetrically in the same animal by a lhoroughly standardized techniquc, has been used before to investigate ihe effect of topical antiseptics on the repair process. The cationic detergents bcnzalkonium chloride and cetylpyridinium chloride (28), dequalinium chlo ride (25) and a cationic triphenylmethane dye, crystal violet (26), in concentrations used clinically all turned out to retard the heaUng processes in incisional wounds closed by silk suture. These results are probably also significant for the heal ing of open wounds, since the differences between the wound-healing processes in wounds healing by primary and secondary intention are con sidered to be quantitative rather than qualitative (l, 31).…”

Microvascular effects of a topically applied cationic triphenylmethane dye (crystal violet)

“…Recently it has been demon�trated in various experimental models that C. V. in con centrations consider ably lower than those used clinically can induce tissue damage (8). The patho physiological mechanisms are unknown, but the dye seems to prolong the initial phase in tissue regeneration due to an intensified and lengthened inflammatory reaction (7). A conceivable explana tion for this would be primary vascular reactions to application of the dye.…”