Development of surface-enhanced Raman spectroscopy application for determination of illicit drugs: Towards a practical sensor

Detection of Alternative Drugs for Illegal Injection Based on Surface-Enhanced Raman Spectroscopy

“…is mechanism may involve the presence of a CTcomplex either by direct binding to the metal or by indirect binding with the assistance of an electrolyte ion [12]. SERS has been widely applied to identify or detect illicit drugs, including trace illicit drugs, suspicious objects and drugs, or their metabolites in real biological system (urine, saliva, and so on) [13]. Currently, SERS researches about illicit drug detection are still in the development stage.…”

Functionalization of metal Nanoparticles for SERS-based Detections of illicit drugs in biological samples

“…One of the main advantages of SERS over Raman is that due to the low sensitivity, Raman is more applicable for the characterization of molecular structures rather than molecular detection. 23 Figure 2 is a schematic to show the differences between SERS and Raman scattering.…”

Dual-triggered nanoaggregates of cucurbit[7]uril and gold nanoparticles for multi-spectroscopic quantification of creatinine in urinalysis

“…Analytical techniques such as Raman spectroscopy and surface-enhanced Raman spectroscopy (SERS) are promising for diagnostic applications as they offer advantages including rapid response, high-sensitivity, cost-effectiveness, ease of use, minimal sample preparation and wider information window of the analyte molecules via their vibrational fingerprints. [19][20][21] SERS can dramatically amplify the Raman signals of the analyte molecules located in close proximity to the plasmonic nanostructures (e.g. gold nanoparticles, Au NPs, and silver nanoparticles, Ag NPs) by 4 to 10 orders of magnitude via strong electromagnetic field enhancement.…”