Development of surgical confocal scanning microscope for intra-operative imaging of brain tumors using near infrared fluorescence: Technicalnote

Sakatani, Kaoru; Kashiwasake-Jibu, Masaki; Terada, Hirotoshi; Zuo, Huancong

doi:10.1080/01616412.2000.11740714

Cited by 6 publications

(5 citation statements)

References 11 publications

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“…Indocyanine green videoangiography (ICG-VAG) has been used as a tool for intraoperative monitoring since about 2000, 8,11,13) and is particularly useful during the neurosurgical treatment of vascular disorders. 8,11,13,18) ICG-VAG was reported as an intraoperative diagnostic imaging technique for evaluating cerebral perfusion in 2003.…”

Section: Introductionmentioning

confidence: 99%

“…8,11,13,18) ICG-VAG was reported as an intraoperative diagnostic imaging technique for evaluating cerebral perfusion in 2003. 11) Subsequently, ICG-VAG has been developed as an easy, rapid, and inexpensive modality.…”

Section: Introductionmentioning

confidence: 99%

“…ICG-VAG can confirm aneurysm occlusion, residual blood flow through perforators of approximately 0.3 mm in diameter, and patency of reconstructed blood vessels. 8,11,13,18) ICG-VAG is useful in cases of aneurysm, vascular reconstruction, and cerebral infarction, [1][2][3][4] and also in some patients with tumorous lesions. 1,5,8,9,11,13,18) In comparison with cerebral angiography, which is a radiographic procedure, ICG-VAG is a fluorescence imaging method and cannot 8,11,13,18) depict the lesion site if the irradiated light is blocked by the brain parenchyma or skin.…”

Section: Introductionmentioning

confidence: 99%

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Indocyanine Green Videoangiography of Optic Cavernous Angioma -Case Report-

Murai

Adachi

Koketsu

et al. 2011

Neurol. Med. Chir.(Tokyo)

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The intraoperative findings of an indocyanine green videoangiography (ICG-VAG) study of a cavernous angioma located in the optic chiasm are reported. A 23-year-old Japanese man suddenly developed visual field loss, and magnetic resonance imaging suggested the presence of a suprasellar tumor in contact with the optic chiasm. Preoperative angiography did not clearly show any tumor shadow. Right fronto-temporal craniotomy was performed, and an aggregation of blood vessels was seen on the right surface of the optic chiasm. Cavernous angioma was suspected. ICG-VAG was begun 22 seconds after the beginning of contrast agent infusion via a peripheral blood vessel. The lesion remained unstained, although the brain surface, an artery superior to the optic nerve, and veins were visualized. The cavernous angioma was resected following surface coagulation. ICG-VAG is currently being evaluated for future application in the differential diagnosis based on imaging findings, and the present case provides an important example of intraoperative ICG-VAG imaging of an unoperated cavernous angioma.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Indocyanine Green Videoangiography of Optic Cavernous Angioma -Case Report-

Murai

Adachi

Koketsu

et al. 2011

Neurol. Med. Chir.(Tokyo)

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“…Also, enhanced optical imaging obtained intraoperatively before and after injection of indocyanine green has been shown as facilitating the localization of tumor, identifying the tumor remaining at the resection margins, and determining the grade of the tumor [347]. Fluorescence-guided resection of gliomas has also been reported [348][349][350][351][352][353][354][355], with the goal to optimize the quality of tumor removal. Moreover, it has been suggested that intraoperative characterization of gliomas by NIRS, based on the study of the intratumoral microvascular blood volume and oxygen saturation, possibly related respectively to angiogenetic activity and non-oxidative glucose metabolism of the lesion, might represent a prognostic factor [356].…”

Section: Image-guided Surgerymentioning

confidence: 97%

Metabolic and Functional Brain Mapping, Connectivity and Plasticity Applied to the Surgery of Cerebral Tumors

Duffau

2005

CMIR

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Although extensive surgical resection represents the first treatment in brain tumors, the risk of postoperative sequelae still persists. Consequently, neurosurgical procedure should be adapted to (1) the behavior of the tumor (2) its cerebral location (3) the individual functional organization of the brain (4) the dynamic interactions between these parameters.I first review the advantages and limitations of the non-invasive metabolic (SPECT, PET, SRM, DWI), functional (PET, fMRI, NIRS, MEG) and anatomical (DTI) neuroimaging techniques, which contribute to select the surgical indications and to plan the procedure. In addition, intraoperative electrical stimulation can be used during the resection, if necessary on awake patient when cognitive functions need to be mapped, in order to detect cortico-subcortical structures functionally essential.Second, the applications of these methods for tumor surgery are considered, with the following interests:-to understand the individual cortical functional organization before the beginning of the resection; -to improve the knowledge of the pathophysiology of brain areas frequently involved by tumor;-to map the subcortical structures all along the resection, allowing a study of the anatomo-functional connectivity;-to study the mechanisms of on-line functional reorganization, using repeated stimulations; -to perform the resection according to functional boundaries, allowing to optimize the quality of lesion removal while minimizing the risk of postoperative sequelae.Finally, the results of pre-, intra-and post-operative functional mappings can be combined, to better understand both short-term and long-term plasticity mechanisms associating functional cortical reshaping and connectivity changes -due initially to the tumor growth, then to its resection.

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“…Since the 1990s, NIR‐I window (700‐900 nm) has gained extensive attention with the development of clinically approved dyes such as ICG, IR‐800, and so on and has resulted in deeper penetration in biological tissues than visible light . Owing to the inverse wavelength dependence of scattering, NIR‐II window can further improve the imaging depth than that of NIR‐I.…”

Section: Introductionmentioning

confidence: 99%

Three‐dimensional cellular imaging in thick biological tissue with confocal detection of one‐photon fluorescence in the near‐infrared II window

Wang

Chen

2019

Journal of Biophotonics

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Fluorescence imaging in the second near‐infrared optical window (NIR‐II, 900‐1700 nm) has become a technique of choice for noninvasive in vivo imaging in recent years. Greater penetration depths with high spatial resolution and low background can be achieved with this NIR‐II window, owing to low autofluorescence within this optical range and reduced scattering of long wavelength photons. Here, we present a novel design of confocal laser scanning microscope tailored for imaging in the NIR‐II window. We showcase the outstanding penetration depth of our confocal setup with a series of imaging experiments. HeLa cells labeled with PbS quantum dots with a peak emission wavelength of 1276 nm can be visualized through a 3.5‐mm‐thick layer of scattering medium, which is a 0.8% Lipofundin solution. A commercially available organic dye IR‐1061 (emission peak at 1132 nm), in its native form, is used for the first time, as a NIR‐II fluorescence label in cellular imaging. Our confocal setup is capable of capturing optically sectioned images of IR‐1061 labeled chondrocytes in fixed animal cartilage at a depth up to 800 μm, with a superb spatial resolution of around 2 μm.

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Development of surgical confocal scanning microscope for intra-operative imaging of brain tumors using near infrared fluorescence: Technicalnote

Cited by 6 publications

References 11 publications

Indocyanine Green Videoangiography of Optic Cavernous Angioma -Case Report-

Indocyanine Green Videoangiography of Optic Cavernous Angioma -Case Report-

Metabolic and Functional Brain Mapping, Connectivity and Plasticity Applied to the Surgery of Cerebral Tumors

Three‐dimensional cellular imaging in thick biological tissue with confocal detection of one‐photon fluorescence in the near‐infrared II window

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