Development of Sustainable Biocatalytic Reduction Processes for Organic Chemists

Wohlgemuth, Roland

doi:10.1002/9783527665785.ch01

Cited by 5 publications

(2 citation statements)

References 140 publications

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“…As such, the development of methodology for the selective addition or deletion of oxygen atoms remains an active area of research (19,20). Recently, biocatalysis has emerged as an enabling platform for the construction and breakage of C-O and X-O bonds, offering exquisite regioselectivity and stereoselectivity (21,22). Enzymes from the DMSO reductase superfamily harbor cofactors that are distinct from those of enzymes used more routinely in biocatalysis, and the biochemical reactions they catalyze may be highly relevant for organic synthesis.…”

Section: Molybdenum and Tungsten In Catalysismentioning

confidence: 99%

Emerging Chemical Diversity and Potential Applications of Enzymes in the DMSO Reductase Superfamily

Bae

Kiamehr

et al. 2022

Annu. Rev. Biochem.

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Molybdenum- and tungsten-dependent proteins catalyze essential processes in living organisms and biogeochemical cycles. Among these enzymes, members of the dimethyl sulfoxide (DMSO) reductase superfamily are considered the most diverse, facilitating a wide range of chemical transformations that can be categorized as oxygen atom installation, removal, and transfer. Importantly, DMSO reductase enzymes provide high efficiency and excellent selectivity while operating under mild conditions without conventional oxidants such as oxygen or peroxides. Despite the potential utility of these enzymes as biocatalysts, such applications have not been fully explored. In addition, the vast majority of DMSO reductase enzymes still remain uncharacterized. In this review, we describe the reactivities, proposed mechanisms, and potential synthetic applications of selected enzymes in the DMSO reductase superfamily. We also highlight emerging opportunities to discover new chemical activity and current challenges in studying and engineering proteins in the DMSO reductase superfamily. Expected final online publication date for the Annual Review of Biochemistry, Volume 91 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Section: Molybdenum and Tungsten In Catalysismentioning

confidence: 99%

Emerging Chemical Diversity and Potential Applications of Enzymes in the DMSO Reductase Superfamily

Bae

Kiamehr

et al. 2022

Annu. Rev. Biochem.

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“…Biocatalytic reaction platforms with numerous biocatalysts and their applications, established over the years for many reaction classes like reductions [40][41] , oxidations [42][43][44] , hydrolysis [45][46] , aminations [47][48] or phosphorylations [49][50] , have paved the way for extending the biocatalyst applications to new substrates and for putting together new synthetic routes. Best practices in the assembly of synthetic biocatalytic as well as chemical synthetic reactions involve rapid prototyping of the most critical reaction steps in order to obtain the first proof-of-principle.…”

Section: Biocatalytic Process Assembly and Prototypingmentioning

confidence: 99%

Biocatalytic Process Design and Reaction Engineering

Wohlgemuth¹

2017

Chem.Biochem.Eng.Q.

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Biocatalytic processes occurring in nature provide a wealth of inspiration for manufacturing processes with high molecular economy. The molecular and engineering aspects of bioprocesses converting available raw materials into valuable products are therefore of much industrial interest. Modular reaction platforms and straightforward working paths, from the fundamental understanding of biocatalytic systems in nature to the design and reaction engineering of novel biocatalytic processes, have been important for shortening development times. Building on broadly applicable reaction platforms and tools for designing biocatalytic processes and their reaction engineering are key success factors. Process integration and intensification aspects are illustrated with biocatalytic processes to numerous small-molecular weight compounds, which have been prepared by novel and highly selective routes, for applications in the life sciences and biomedical sciences.

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Chirality Related to Biocatalysis and Enzymes in Organic Synthesis

Gavin¹,

Maguire²

2016

Chirality in Supramolecular Assemblies

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Development of Sustainable Biocatalytic Reduction Processes for Organic Chemists

Cited by 5 publications

References 140 publications

Emerging Chemical Diversity and Potential Applications of Enzymes in the DMSO Reductase Superfamily

Emerging Chemical Diversity and Potential Applications of Enzymes in the DMSO Reductase Superfamily

Biocatalytic Process Design and Reaction Engineering

Chirality Related to Biocatalysis and Enzymes in Organic Synthesis

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