Development of synaptic connectivity in the retinal direction selective circuit

Morrie, Ryan D.; Feller, Marla B.

doi:10.1016/j.conb.2016.06.009

Cited by 22 publications

(9 citation statements)

References 65 publications

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“…Moreover, the altered morphology of Sema6A -/- SACs has revealed a dissociation within the SAC arbor between connectivity and intrinsic directional preference. While asymmetric wiring with DSGCs is likely instructed by the segregation of different signaling molecules at proximal SAC dendrites [39, 40], we find that the directional preferences of varicosities on that dendrite are determined at a more distal location. Further functional analysis of morphological alterations in SACs [15, 54] and other neurons [14, 41] can help elucidate the underlying cellular and molecular mechanisms that link dendritic structure, wiring, and computation.…”

Section: Discussionmentioning

confidence: 87%

A Dense Starburst Plexus Is Critical for Generating Direction Selectivity

Morrie

Feller

2018

Current Biology

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Starburst amacrine cell (SAC) morphology is considered central to retinal direction selectivity. In Sema6A mice, SAC dendritic arbors are smaller and no longer radially symmetric, leading to a reduction in SAC dendritic plexus density. Sema6A mice also have a dramatic reduction in the directional tuning of retinal direction-selective ganglion cells (DSGCs). Here we show that the loss of DSGC tuning in Sema6A mice is due to reduced null direction inhibition, even though strong asymmetric SAC-DSGC connectivity and SAC dendritic direction selectivity are maintained. Hence, the reduced coverage factor of SAC dendrites leads specifically to a loss of null direction inhibition. Moreover, SAC dendrites are no longer strictly tuned to centrifugal motion, indicating that SAC morphology is critical in coordinating synaptic connectivity and dendritic integration to generate direction selectivity.

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Section: Discussionmentioning

confidence: 87%

A Dense Starburst Plexus Is Critical for Generating Direction Selectivity

Morrie

Feller

2018

Current Biology

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“…Concurrent with such changes, many new connections are rapidly being formed in the nervous system (Gilmore et al, 2018); Semple et al (2013); Levitt, 2003), suggesting that the formation of new connections is linked to the development of the behavioral repertoire. However, despite many studies that carried out circuit-level examination of the postnatal formation of new connections (Morrie and Feller, 2016; Polley et al, 2013; Stein and Stanford, 2013; Kano and Watanabe, 2013) very little is known still of how nascent connections are organized to support a behavioral repertoire that grows by including increasingly more sophisticated behaviors while retaining vital reflexive behaviors.…”

Section: Introductionmentioning

confidence: 99%

Chronology-based architecture of descending circuits that underlie the development of locomotor repertoire after birth

Pujala

Koyama

2019

eLife

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The emergence of new and increasingly sophisticated behaviors after birth is accompanied by dramatic increase of newly established synaptic connections in the nervous system. Little is known, however, of how nascent connections are organized to support such new behaviors alongside existing ones. To understand this, in the larval zebrafish we examined the development of spinal pathways from hindbrain V2a neurons and the role of these pathways in the development of locomotion. We found that new projections are continually layered laterally to existing neuropil, and give rise to distinct pathways that function in parallel to existing pathways. Across these chronologically layered pathways, the connectivity patterns and biophysical properties vary systematically to support a behavioral repertoire with a wide range of kinematics and dynamics. Such layering of new parallel circuits equipped with systematically changing properties may be central to the postnatal diversification and increasing sophistication of an animal’s behavioral repertoire.

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“…There are four ooDSGC types, each responsive to motion in one of 4 directions (ventral, dorsal, nasal, and temporal) (Oyster and Barlow, 1967). The four types share many structural and physiological properties but exhibit some molecular differences (Huberman et al, 2009; Kay et al, 2011a; Morrie and Feller, 2016). To find genes involved in establishing type-specific features, we used a gene expression database generated from 17 sets of retinal cells that we had transcriptionally profiled (Kay et al, 2012; Kay et al, 2011b).…”

Section: Introductionmentioning

confidence: 99%

Satb1 Regulates Contactin 5 to Pattern Dendrites of a Mammalian Retinal Ganglion Cell

Peng

Tran

Krishnaswamy

et al. 2017

Neuron

113

140

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SUMMARY The size and shape of dendritic arbors are prime determinants of neuronal connectivity and function. We asked how ON-OFF direction-selective ganglion cells (ooDSGCs) in mouse retina acquire their bistratified dendrites, in which responses to light-onset and light-offset are segregated to distinct strata. We found that the transcriptional regulator Satb1 is selectively expressed by ooDSGCs. In Satb1 mutant mice, ooDSGC dendrites lack ON arbors and the cells selectively lose ON responses. Satb1 regulates expression of a homophilic adhesion molecule, Contactin 5 (Cntn5). Both Cntn5 and its co-receptor Caspr4 are expressed not only by ooDSGCs but also by interneurons that form a scaffold on which ooDSGC ON dendrites fasciculate. Removing Cntn5 from either ooDSGCs or the interneurons partially phenocopies Satb1 mutants, demonstrating that Satb1-dependent Cntn5 expression in ooDSGCs leads to branch-specific homophilic interactions with interneurons. Thus, Satb1 directs formation of a morphologically and functionally specialized compartment within a complex dendritic arbor.

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Development of synaptic connectivity in the retinal direction selective circuit

Cited by 22 publications

References 65 publications

A Dense Starburst Plexus Is Critical for Generating Direction Selectivity

A Dense Starburst Plexus Is Critical for Generating Direction Selectivity

Chronology-based architecture of descending circuits that underlie the development of locomotor repertoire after birth

Satb1 Regulates Contactin 5 to Pattern Dendrites of a Mammalian Retinal Ganglion Cell

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