Development of Synthetic Pan-Selectin Antagonists: A New Treatment Strategy for Chronic Inflammation in Asthma

Aydt, Ewald M.; Wolff, Gerhard

doi:10.1159/000070746

Cited by 28 publications

(25 citation statements)

References 26 publications

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“…Structural mimetics of selectin ligands have been described to block selectin ligand function under in vitro conditions (Kogan et al, 1998). This may open a new and interesting avenue to manipulate selectin-dependent rolling in vivo (Aydt and Wolff, 2002).…”

Section: Manipulation Of Selectin-dependent Leukocyte Rollingmentioning

confidence: 99%

Analysis of Leukocyte Rolling In Vivo and In Vitro

Sperandio

Pickard²,

Unnikrishnan³

et al. 2006

Methods in Enzymology

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. Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase. Cell 105, 957-969. Yeh, J. C., Ong, E., and Fukuda, M. (1999). Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches. J. Biol. Chem. 274, 3215-3221. Yousefi, S., Higgins, E., Daoling, Z., Pollex-Kruger, A., Hindsgaul, O., and Dennis, J. W.(1991). Increased UDP-GlcNAc:Gal beta 1-3GaLNAc-R (GlcNAc to GalNAc) beta-1, 6-N-acetylglucosaminyltransferase activity in metastatic murine tumor cell lines. Control of polylactosamine synthesis. J. Biol. Chem. 266, 1772-1782. Zhang, J., Nakayama, J., Ohyama, C., Suzuki, M., Suzuki, A., Fukuda, M., and Fukuda, M. N. (2002). Sialyl Lewis X-dependent lung colonization of B16 melanoma cells through a selectin-like endothelial receptor distinct from E-or P-selectin. Cancer Res. 62, 4194-4198.[23] Analysis of Leukocyte Rolling In Vivo and In VitroBy MARKUS SPERANDIO, JOHN PICKARD, SUNIL UNNIKRISHNAN, SCOTT T. ACTON, and KLAUS LEY Abstract Leukocyte rolling is an important step for the successful recruitment of leukocytes from blood to tissues mediated by a specialized group of glycoproteins termed selectins. Because of the dynamic process of leukocyte rolling, binding of selectins to their respective counter-receptors (selectin ligands) needs to fulfill three major requirements: (1) rapid bond formation, (2) high tensile strength, and (3) fast dissociation rates. These criteria are perfectly met by selectins, which interact with specific carbohydrate determinants on selectin ligands. This chapter describes the theoretical background, technical requirements, and analytical tools needed to quantitatively assess leukocyte rolling in vivo and in vitro. For the in vivo setting, intravital microscopy allows the observation and recording of leukocyte rolling under different physiological and pathological conditions in almost every organ. Real-time and off-line analysis tools help to assess geometric, hemodynamic, and rolling parameters. Under in vitro

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Section: Manipulation Of Selectin-dependent Leukocyte Rollingmentioning

confidence: 99%

Analysis of Leukocyte Rolling In Vivo and In Vitro

Sperandio

Pickard²,

Unnikrishnan³

et al. 2006

Methods in Enzymology

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“…This pan-selectin antagonist has been successfully investigated in different preclinical models of inflammatory diseases such as psoriasis, asthma and reperfusion injury [17]. Bimosiamose is at present the most advanced small molecule selectin inhibitor in development [18]. It is in a phase IIa clinical trial for the treatment of allergic asthma, where a single intravenous administration improves several disease parameters such as decreasing eosinophil airway recruitment [18].…”

Section: Selectin Inhibitorsmentioning

confidence: 99%

Inhibitors of Membrane Receptors Involved with Leukocyte Extravasation

Bendas

2005

MRMC

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The migration of leukocytes from the blood stream to sites of infection is a key event in cellular immune response, mediated by multiple types of molecules including several adhesion receptors. The inhibition of adhesion receptors holds great promise for novel therapeutical strategies to treat chronic inflammatory disorders or autoimmune diseases. This review reports on recent advances in adhesion-based therapeutics and focuses on structural classification of selectin and integrin inhibitors.

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“…pearance or up-regulation of CAMs has been observed in a variety of central nervous system (CNS) diseases (5)(6)(7)(8) and the therapeutic approaches blocking leukocyte-endothelium interactions have provided encouraging results, suggesting that these molecules have a pivotal role (9)(10)(11)(12)(13).…”

Section: T Tanriverdi Et Almentioning

confidence: 99%

Serum and cerebrospinal fluid concentrations of E-selectin in patients with aneurysmal subarachnoid hemorrhage

Tanrıverdi

Sanuş

Ulu

et al. 2005

Braz J Med Biol Res

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The goal of the present study was to determine concentrations of Eselectin in both cerebrospinal fluid (CSF) and serum of patients with aneurysmal subarachnoid hemorrhage (SAH) and to evaluate the correlation between the clinical parameters and E-selectin levels. Both CSF and serum samples obtained from 12 patients with aneurysmal SAH and 8 patients with hydrocephalus (control group) without any other known central nervous system disease were assayed for Eselectin by quantitative enzyme-linked immunosorbent assay and the results were compared between the two groups. Mean levels of soluble forms of E-selectin within the first 3 days and on the 5th and 7th days of SAH were 4.0 ± 7.9, 2.8 ± 5.2, and 3.1 ± 4.9 ng/ml in the patient's CSF, and 33.7 ± 9.2, 35.1 ± 7.0, and 35.2 ± 8.7 ng/ml in serum, respectively. In contrast, mean E-selectin levels were 0.1 ± 0.2 ng/ml in CSF and 8.7 ± 5.0 ng/ml in serum of control patients. The difference between groups was statistically significant regarding both CSF and serum E-selectin levels (P < 0.05). Thus, we have demonstrated a marked increase of E-selectin concentration in both CSF and serum of patients with aneurysmal SAH compared with control and suggest that blocking the interaction between E-selectin and vascular endothelium may have a beneficial effect on vasospasms.

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Development of Synthetic Pan-Selectin Antagonists: A New Treatment Strategy for Chronic Inflammation in Asthma

Cited by 28 publications

References 26 publications

Analysis of Leukocyte Rolling In Vivo and In Vitro

Analysis of Leukocyte Rolling In Vivo and In Vitro

Inhibitors of Membrane Receptors Involved with Leukocyte Extravasation

Serum and cerebrospinal fluid concentrations of E-selectin in patients with aneurysmal subarachnoid hemorrhage

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