Development of target-specific multimodality imaging agent by using hollow manganese oxide nanoparticles as a platform

Abstract

A platform protocol developed based on the hollow manganese oxide nanoparticles provided multimodal diagnostic agents, which allow the selectively detect vulva cancer with T(1)-weighted in vivo MRI.

Hollow manganese oxide nanoparticle-enhanced MRI of hypoxic-ischaemic brain injury in the neonatal rat

“…HMON plays as dual contrast agent for T 1 and T 2 weighted MR images. 18,19 Although the mechanism for HMON accumulation remains unclear, it can be inferred that the increased relaxivity of the HMON is mainly due to the increased concentration of manganese ions exposed at the hollow inner surface. 18 We demonstrated HMON enhancement in the specific areas of the injured hemisphere after HII, which was in accordance with the results of previous studies using manganese-enhanced MRI.…”

“…HMON has an enhanced relaxivity attributed to its large water-accessible surface area, improved diagnostic performance with long blood circulation time and the flexibility of many options for functional modifications of the surface and hollow centre. 18,19 The aim of our study was to determine the utility of HMON-enhanced MRI in depicting and monitoring apoptotic area following hypoxic-ischaemic injury in a neonatal rat brain and to evaluate the longitudinal evolution of HII up to 21 days. Animal model of hypoxic-ischaemic brain injury HII was induced using the Rice-Vannucci model 20,21 in 7-dayold Sprague-Dawley rat pups (n 5 17, 13-17 g).…”

A Hybrid Silica Nanoreactor Framework for Encapsulation of Hollow Manganese Oxide Nanoparticles of Superior T1 Magnetic Resonance Relaxivity

“…Since only the surface Mn 2+ ions in a nanoparticle are largely responsible for the longitudinal water proton relaxation, these hollow MONs tend to exhibit higher r 1 relaxivities than those of their solid counterparts. Herein, there has been a burgeoning interest to use hollow MONs as a platform to build an integrated MRI diagnostic and therapeutic nanoprobe for various types of cancers …”

Magnetic resonance imaging for monitoring therapeutic response in a transgenic mouse model of Alzheimer’s disease using voxel-based analysis of amyloid plaques

“…We showed previously the potential usefulness of HMON conjugated with an antibody for diagnostic imaging for targeting specific tumor cells in vivo 22 and for targeting amyloid plaques in vivo 14. In this work, we showed the feasibility of our voxel-based method in using the HMON-abAβ40 contrast agent as a noninvasive monitoring tool for evaluation of the therapeutic response of a potential drug for AD.…”