Development of telencephalin in the human cerebrum

Arii, N.; Mizuguchi, Masashi; Mori, Kensaku; Takashima, Sachio

doi:10.1002/(sici)1097-0029(19990701)46:1<18::aid-jemt2>3.0.co;2-g

Cited by 8 publications

(2 citation statements)

References 14 publications

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“…115 ICAM-5 (telencephalin) has 9 Ig domains and a molecular weight of 130 kd. 116 It is a glycoprotein that is expressed by a subset of neurons (somato-dendritic) within the telencephalon of the mammalian brain. [117][118][119][120][121] ICAM-5 can bind to CD11a/CD18 expressed by T lymphocytes.…”

Section: Immunoglobulin Superfamily Of Adhesion Moleculesmentioning

confidence: 99%

Cell Adhesion Molecules, Leukocyte Trafficking, and Strategies to Reduce Leukocyte Infiltration

2001

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Section: Immunoglobulin Superfamily Of Adhesion Moleculesmentioning

confidence: 99%

Cell Adhesion Molecules, Leukocyte Trafficking, and Strategies to Reduce Leukocyte Infiltration

2001

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Section: Immunoglobulin Superfamily Of Adhesion Moleculesmentioning

confidence: 60%

Cell Adhesion Molecules, Leukocyte Trafficking, and Strategies to Reduce Leukocyte Infiltration

Radi

Kehrli

Ackermann

2001

Veterinary Internal Medicne

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Leukocyte‐endothelial cell interactions are mediated by various cell adhesion molecules. These interactions are important for leukocyte extravasation and trafficking in all domestic animal species. An initial slowing of leukocytes on the vascular endothelium is mediated by selectins. This event is followed by (1) activation of β2 integrins after leukocyte exposure to cytokines and proinflammatory mediators, (2) adherence of leukocyte β2 integrins to vascular endothelial ligands (eg, intercellular adhesion molecule‐1 [ICAM‐1]), (3) extravasation of leukocytes into tissues through tight junctions of endothelial cells mediated by platelet and endothelial cell adhesion molecule‐1 (PECAM‐1), and (4) perivascular migration through the extracellular matrix via β1 integrins. Inhibiting excessive leukocyte egress and subsequent free radical‐mediated damage caused by leukocyte components may attenuate or eliminate tissue damage. Several methods have been used to modify leukocyte infiltration in various animal models. These methods include nonspecific inhibition of pro‐inflammatory mediators and adhesion molecules by nonsteroidal anti‐inflammatory drugs (NSAIDs) and glucocorticoids, inhibition of cytokines and cytokine receptors, and inhibition of specific types of cell adhesion molecules, with inhibitors such as peptides and antibodies to β2 integrins, and inhibitors of selectins, ICAMs, and vascular cell adhesion molecule‐1 (VCAM‐1). By understanding the cellular and molecular events in leukocyte‐endothelial cell interactions, therapeutic strategies are being developed in several animal models and diseases in domestic animal species. Such therapies may have clinical benefit in the future to overcome tissue damage induced by excessive leukocyte infiltration.

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A new algorithm for analysis of oligonucleotide arrays: application to expression profiling in mouse brain regions

Zhang

Wang

Ravindranathan

et al. 2002

Journal of Molecular Biology

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Development of telencephalin in the human cerebrum

Cited by 8 publications

References 14 publications

Cell Adhesion Molecules, Leukocyte Trafficking, and Strategies to Reduce Leukocyte Infiltration

Cell Adhesion Molecules, Leukocyte Trafficking, and Strategies to Reduce Leukocyte Infiltration

Cell Adhesion Molecules, Leukocyte Trafficking, and Strategies to Reduce Leukocyte Infiltration

A new algorithm for analysis of oligonucleotide arrays: application to expression profiling in mouse brain regions

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