Development of the B- and T-cell compartments in porcine lymphoid organs from birth to adult life: an immunohistological approach

Bianchi, A.T.J.; Zwart, Rob; Jeurissen, S.H.M.; Moonen-Leusen, H.W.

doi:10.1016/0165-2427(92)90182-p

Cited by 97 publications

(74 citation statements)

References 25 publications

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“…In particular, newborn piglets have essentially no leucocytes, despite the more advanced development of piglets at term compared to human or rodent neonates [44,53]. This is true for lamina propria leucocytes of any type, including antigen presenting cells, T-cells or B cells [9,45,46] and unpublished data 1,2 . The relatively impermeable epitheliochorial placenta of the pig, which does not permit the transfer of macromolecules from sow to foetus, either antibody or exogenous antigen, makes the newborn piglet entirely immunologically naïve and may explain this profound lack of immune development of the newborn piglet.…”

Section: Development Of the Diffuse Lymphoid Architecture In The Neonatementioning

confidence: 88%

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The postnatal development of the mucosal immune system and mucosal tolerance in domestic animals

Bailey

Haverson²

2006

Vet. Res.

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-The mucosal immune system is exposed to a range of antigens associated with pathogens, to which it must mount active immune responses. However, it is also exposed to a large number of harmless antigens associated with food and with commensal microbial flora, to which expression of active, inflammatory immune responses to these antigens is undesirable. The mucosal immune system must contain machinery capable of evaluating the antigens to which it is exposed and mounting appropriate effector or regulatory responses. Since the immune system is likely to have evolved initially in mucosal tissues, the requirement to prevent damaging allergic responses must be at least as old as the adaptive immune system, and studies of the mechanisms should include a range of non-mammalian species. Despite the importance for rational design of vaccines and for control of allergic reactions, the mechanisms involved are still largely unclear. It is not clear that the classical experimental protocol of "oral tolerance" is, in fact, measuring a biologically important phenomenon, nor is it clear whether tolerance is regulated in the evolutionarily recent organised lymphoid tissue (the lymph nodes) or the more ancient, diffuse architecture in the intestine. The capacity of the immune system to discriminate between "dangerous" and "harmless" antigens appears to develop with age and exposure to microbial flora. Thus, the ability of an individual or a group of animals to correctly regulate mucosal immune responses will depend on age, genetics and on their microbial environment and history. Attempts to manipulate the mucosal immune system towards active immune responses by oral vaccines, or towards oral tolerance, are likely to be confounded by environmentally-induced variability between individuals and between groups of animals.

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Section: Development Of the Diffuse Lymphoid Architecture In The Neonatementioning

confidence: 88%

“…I) [9,44,53]. Strongly MHC II+ cells, characterised as dendritic cells by co-expression of CD45, CD16 and other myeloid markers [26] appear relatively quickly and in large numbers in this site, within the first week of age [32].…”

Section: Development Of the Diffuse Lymphoid Architecture In The Neonatementioning

confidence: 99%

The postnatal development of the mucosal immune system and mucosal tolerance in domestic animals

Bailey

Haverson²

2006

Vet. Res.

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“…The germinal center contains B cells engaged in intense proliferative activity. The dome region and corona areas between the germinal center and dome region contains B cells, T cells, and macrophages [1,5,14]. The interfollicular areas contain mainly T cells [1,11].…”

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confidence: 99%

“…The dome region and corona areas between the germinal center and dome region contains B cells, T cells, and macrophages [1,5,14]. The interfollicular areas contain mainly T cells [1,11]. In the small intestines, each follicle extends into a dome region, the dome villous, that is covered by a specialized epithelium, the follicle associated epithelium [4,5].…”

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confidence: 99%

Lectin Histochemistry of Peyer's Patches in the Porcine Ileum.

Jeong

Sohn

Ahn

et al. 2002

The Journal of Veterinary Medical Science

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ABSTRACT. Lectin staining pattern in Peyer's patches of porcine ileum was studied using twenty one biotinylated-labeled lectins as cell markers which were visualized with avidin-biotin-peroxidase complex method (ABC). WGA appears to be a selective marker for tingible body macrophages in the porcine germinal centers. ConA may be a positive marker for the lymphoid tissues, whereas 9 lectins (DBA, SBA, SJA, s-WGA, PNA, ECL, UEA-I, PHA-E, and PHA-L) may be negative markers for the lymphoid tissues in all areas. KEY WORDS: histochemistry, lectin, Peyer's patch.

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“…Porcine mucosal immune system is functionally immature at birth, but develops during perinatal period reaching adult values between 5 and 7 weeks of life (Bianchi et al, 1992;Vega-Lopez et ., 1995;Pabst and Rotkötter, 1999). It has been found that F4 + antigen of ETEC strains stimulated the production of IgA and IgG antibodies (Dean-Nystrom et al, 1992) and T cell mediated immune responses in the intestinal mucosa of experimentally inoculated pigs (Valpotić et al, 1994).…”

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confidence: 99%

Functional and phenotypic analyses of porcine gut immune cells immunized by oral administration of F4ac<sup>+</sup>nonenterotoxigenic Escherichia coli strains

Vijtiuk¹,

Trutin-Ostović²,

Balenović³

et al. 2002

Vet. Med. - Czech

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e aim of this study was to determine the priming effect of experimentally inoculated non-ETEC strains (2407, 1466) on gastrointestinal mucosal lymphocytes. Five 4-week-old pigs per group were orally inoculated with either F4ac + (1466 or 2407) or F4 -(1467) non-ETEC strains. e control pigs were given broth containing 1.2% sodium bicarbonate. At postinoculation Day 6 the pigs were killed, their gut lymphocytes were isolated, and their responsiveness was tested in vitro with F4 antigen, peptidoglycan monomer (PGM), pokeweed mitogen (PWM), phytohemagglutinin (PHA) and lipopolysaccharide (LPS). Additionally, the patterns of cluster of differentiation (CD) antigen expression on T and B cells in the single cell suspensions from JLP, IPP, and MLN were determined by flow cytometry using anti-swine CD-specific monoclonal antibodies. F4ac + non-ETEC strain 2407 and, to a lesser extent 1466, activated lymphocytes from PP and MLN to respond better to common mitogens (PHA, PWM, LPS), purified fimbrial (F4ac) antigen or immunologic response modifier (PGM). An increase of CD2a + and CD8a + T cells in JLP, and species-specific SWC1 + T cells in MLN (P < 0.05) was detected in 2407-treated pigs. In conclusion, inoculation with non-ETEC strain 2407 exhibited stimulatory properties to porcine gut immune cells, and thus, could be used in the vaccination programs to control the postweaning colibacillosis in pigs.

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Development of the B- and T-cell compartments in porcine lymphoid organs from birth to adult life: an immunohistological approach

Cited by 97 publications

References 25 publications

The postnatal development of the mucosal immune system and mucosal tolerance in domestic animals

The postnatal development of the mucosal immune system and mucosal tolerance in domestic animals

Lectin Histochemistry of Peyer's Patches in the Porcine Ileum.

Functional and phenotypic analyses of porcine gut immune cells immunized by oral administration of F4ac<sup>+</sup>nonenterotoxigenic Escherichia coli strains

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