Development of the boston retinal prosthesis

Rizzo, Joseph F.; Shire, D. B.; Kelly, Shawn K.; Troyk, Philip R.; Gingerich, Marcus D.; McKee, Bruce; Priplata, Attila A.; Chen, Jinghua; Drohan, William A.; Doyle, Patrick S.; Mendoza, Oscar; Theogarajan, Luke; Cogan, Stuart F.; Wyatt, John L.

doi:10.1109/iembs.2011.6090855

Cited by 19 publications

(14 citation statements)

References 18 publications

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“…Hier liegen die Reizelektroden im Subretinalraum. Eine Kamera fängt das Bild ein, Stimulationspulse werden berechnet und die Information wird mittels Hochfrequenzübertragung an das Implantat gesendet [30]. Leider gibt es keine aktuelleren konkreten Informationen oder Daten zum Stand des Projekts.…”

Section: Boston Retina Implantunclassified

Zukünftige Entwicklungen bei implantierbaren Netzhautprothesen

Walter

2016

Klin Monatsbl Augenheilkd

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Implantable retinal prostheses for the blind are already in use. In blind subjects suffering from retinitis pigmentosa (RP), these systems are able to induce phosphenes. However, the measurable gain in vision is limited. This is due to degeneration in the retina itself and to the technology, which is used in the currently available systems. Research groups and companies are working on solutions and prototypes to improve the outcome of electrical stimulation in the visual system. One improvement will be to enlarge the electrode array in order to restore a larger visual field. A second approach is to enlarge the number of electrodes and to place them at a higher density to improve the spatial resolution of the system. A third concept is to develop a recording unit within the electrode array to analyse ganglion cell behaviour underneath the electrode. This information can than be used to optimise the stimulation pattern. Not only retinal prostheses are under development but also systems to stimulate the retina from the suprachoroidal space, to directly stimulate the optic nerve or the lateral geniculate body or even the primary visual cortex.

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Section: Boston Retina Implantunclassified

Zukünftige Entwicklungen bei implantierbaren Netzhautprothesen

Walter

2016

Klin Monatsbl Augenheilkd

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“…Visual prostheses are being developed by numerous groups around the world as a strategy to restore vision to patients affected by neural forms of blindness. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Each of these approaches seeks to bypass damaged or dysfunctional nerve tissue to deliver visually relevant neural stimulation along surviving visual pathways. [21][22][23][24][25] The most significant challenge for any neurosensory prosthesis is achieving a biocompatible interface in which mechanical and electrochemical damage are minimized to increase the potential for psychophysical benefit.…”

Section: Introductionmentioning

confidence: 99%

Implantation and Extraction of Penetrating Electrode Arrays in Minipig Retinas

Chen

Poulaki

Kim

et al. 2020

Trans. Vis. Sci. Tech.

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This work was motivated by the goals of demonstrating methods to fabricate and implant large numbers of penetrating arrays into the retina and the feasibility of extraction. Methods: Arrays of inactive, three-dimensional (3D) SU-8 structures were microfabricated onto 13-μm polyimide substrates. Standard vitreoretinal surgical techniques were used with an ab externo approach for subretinal implantation of arrays in 12 mini-pigs. In the first three surgeries, different post-geometries were explored, while a preferred design (128-μm tall, 30-μm diameter, 200-μm spacing) was used for the remaining nine implantations. Two arrays were extracted. Funduscopy, optical coherence tomography (OCT) and immunohistochemistry of the retinae were performed. The unoperated eyes and tissue far from implantation served as controls. A thirteenth pig was implanted with a planar array. Results: Ten implant surgeries had no significant complication, and two arrays were successfully extracted. One retinal tear occurred after implantation due to too long posts in an early surgery. In "successful" cases, OCT showed close apposition of the arrays to the retina and integration of the posts, the tops of which were positioned at the junction of the inner plexiform and ganglion cells, without significant gliosis. Conclusions: These results provide a proof-of-concept that relatively large numbers of 3D posts can be implanted into, and extracted from, the retina of mini-pigs. Our surgical numbers were relatively small, especially for the extractions, and our conclusions must be viewed with that limitation. Our methods are applicable for human surgeries. Translational Relevance: This study provides results of implantation and extraction of relatively large numbers of 3D posts from the retina of minipig eyes. If similar technology were used in humans, a 3D array of this type should lower perceptual thresholds, provide safer long-term stimulation, and perhaps provide better perceptual outcomes.

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“…3 Recent developments of low power consumption devices enabled the realization of wireless tissue and in-body implants. The possibility to address implants wirelessly extended their application potential enormously, with numerous systems already available, including drug-delivery platforms, 4 cochlear implants, 5 pressure monitors in the brain cavity, 6 glaucoma sensors, 6,7 retinal implants, 6,8,9 brain-to-nerve interconnections for cerebral injuries 10 and direct control of prostheses. [11][12][13] There are several issues to consider while designing an in-body implant, for example, its power consumption, biocompatibility and the total size of the system.…”

Section: Introductionmentioning

confidence: 99%

Compact helical antenna for smart implant applications

2015

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Smart implants are envisioned to revolutionize personal health care by assessing physiological processes, for example, upon wound healing, and communicating these data to a patient or medical doctor. The compactness of the implants is crucial to minimize discomfort during and after implantation. The key challenge in realizing small-sized smart implants is high-volume cost-and time-efficient fabrication of a compact but efficient antenna, which is impedance matched to 50 Ω, as imposed by the requirements of modern electronics. Here, we propose a novel route to realize arrays of 5.5-mm-long normal mode helical antennas operating in the industry-scientific-medical radio bands at 5.8 and 2.4 GHz, relying on a self-assembly process that enables large-scale high-yield fabrication of devices. We demonstrate the transmission and receiving signals between helical antennas and the communication between an antenna and a smartphone. Furthermore, we successfully access the response of an antenna embedded in a tooth, mimicking a dental implant. With a diameter of~0.2 mm, these antennas are readily implantable using standard medical syringes, highlighting their suitability for in-body implant applications.

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Development of the boston retinal prosthesis

Cited by 19 publications

References 18 publications

Zukünftige Entwicklungen bei implantierbaren Netzhautprothesen

Zukünftige Entwicklungen bei implantierbaren Netzhautprothesen

Implantation and Extraction of Penetrating Electrode Arrays in Minipig Retinas

Compact helical antenna for smart implant applications

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