Development of the Fetal Duodenum: A Postmortem Study

Desdicioğlu, Kadir; Malas, Mehmet Ali; Evcil, Emine Hilal

doi:10.1159/000236354

Cited by 10 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We did not observe statistically significant differences when groups A and B were compared. The SIL and CL, the TBL, and the AL did not show any differences between the genders, in keeping with the findings in duodenal and vermiform appendix lengths reported by others [10,14]. In maceration, our study shows that only the CL is affected.…”

Section: Discussionsupporting

confidence: 92%

“…They also reported that the total small and large intestinal lengths are decreased in the 3rd-pregnancy trimester IUGR fetuses [1]. The most recent and extensive work on the growth of the human fetal gastrointestinal tract originates from a single research group [10][11][12][13][14]. These authors did not focus on intestinal length measurements, although they do report that the lengths of the cecum and vermiform appendix increase with GA, and they give a length range of 5 to 45 mm for AL during the fetal period [12,14].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Development of Fetal Intestinal Length during 2nd-Trimester in Normal and Pathologic Pregnancies

et al. 2012

View full text Add to dashboard Cite

Linear growth of the human fetal gastrointestinal tract is not often discussed in the literature, and little is known about the effects of chromosomal abnormalities and intrauterine growth restriction (IUGR) on intestinal length, especially during the 2nd trimester. Accurate evaluation of intestinal length and knowledge of normal and reference values are of clinical importance. For example, intestinal resection may be necessary in preterm infants with necrotizing enterocolitis or mid-gut volvulus, and the surgeon should use data to be judicious in the amount removed. Linear measurements are essential in evaluating fetal development ultrasonographically and are an integral part of the postmortem examination. The intestinal lengths of 203 2nd-trimester fetuses and premature infants were measured. Small intestine length (SIL), colon length (CL), total bowel length (TBL; TBL = SIL + CL), and the length of the appendix (AL) increased with gestational age. No differences between the genders were observed. Colon length increased secondary to maceration, but no such effects were shown on SIL, TBL, or AL. No differences were shown in relation to IUGR. Small intestine length, CL, and TBL, but not AL, were shorter in fetuses with trisomy 21. Appendix length was not affected by any of the studied factors. We propose that the measurement of the length of the appendix may be used as an additional parameter for the postmortem evaluation of gestational age. Furthermore, its assessment may have potential as an ultrasonographic indicator of gestational age, particularly for the 2nd trimester.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Development of Fetal Intestinal Length during 2nd-Trimester in Normal and Pathologic Pregnancies

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In our study, both points C and P were located near the midsagittal plane and gradually stabilized after CS20. A previous article described that the pyloric segment was also located near the midsagittal plane in the early fetal period (Desdicioglu et al, 2009). Hawass et al (1991) observed similar results, specifically that the axis between the gastroesophageal junction and pyloric canal was almost parallel to the long axis of the body at 7.5-8.5 weeks.…”

Section: Discussionmentioning

confidence: 96%

Morphogenesis and Three‐Dimensional Movement of the Stomach During the Human Embryonic Period

Kaigai

Nako

Yamada

et al. 2013

The Anatomical Record

View full text Add to dashboard Cite

The stomach develops as the local widening of the foregut after Carnegie stage (CS) 13 that moves in a dramatic and dynamic manner during the embryonic period. Using the magnetic resonance images of 377 human embryos, we present the morphology, morphometry, and threedimensional movement of the stomach during CS16 and CS23. The stomach morphology revealed stage-specific features. The angular incisura and the cardia were formed at CS18. The change in the angular incisura angle was approximately 90 during CS19 and CS20, and was <90 after CS 21. The prominent formations of the fundus and the pylorus differentiate at around CS20. Morphometry of the stomach revealed that the stomach gradually becomes "deflected" during development. The stomach may appear to move to the left laterally and caudally due to its deflection and differential growth. The track of the reference points in the stomach may reflect the visual three-dimensional movement. The movement of point M, representing the movement of the greater curvature, was different from that of points C (cardia) and P (pyloric antrum). The P and C were located just around the midsagittal plane in all the stages observed. Point M moved in the caudal-left lateral direction until CS22. Moreover, the vector CP does not rotate around the dorsoventral axis, as widely believed, but around the transverse axis. The plane CPM rotated mainly around the longitudinal axis. The data obtained will be useful for prenatal diagnosis in the near future. Anat Rec, 297:791-797, 2014. V C 2013 Wiley Periodicals, Inc.Key words: stomach; human embryo; magnetic resonance imaging; three-dimensional movementAbbreviations used: A 5 angular incisura; C 5 cardia; C1 5 first cervical vertebra; CS 5 Carnegie stage; 3D 5 three-dimensional; E 5 esophagus, which crosses the border between the chest and the abdominal cavities; Lgc 5 lengths of greater curvature; Llc 5 lesser curvature; MLP 5 maximum longitudinal plane; MR 5 magnetic resonance; P 5 pyloric antrum; Th8 5 8th thoracic vertebra; Um 5 middle cranial edge of the umbilicus. This article includes AR WOW Videos, which can be viewed at

show abstract

“…Early in the fourth week, the duodenum begins to develop from the caudal end of the foregut, the cranial end of the midgut, and the splanchnic mesoderm which is the connection between these endodermal parts. [1] The villi and the crypts of Lieberkuhn begin to appear during the 8th week and 3rd month, respectively. [2] In addition, Brunner's glands appear in the proximal duodenum by 12-14 weeks.…”

Section: Introductionmentioning

confidence: 99%

“…[2] In addition, Brunner's glands appear in the proximal duodenum by 12-14 weeks. [1,2] The mature duodenum is lined by finger-like villi, which are shorter and blunter than those found in the Özet: ‹nsan fetüsünde duodenumun morfometrik analizi jejunum and ileum. The shortest villi are located in the proximal duodenum and become progressively longer distally.…”

Section: Introductionmentioning

confidence: 99%

Morphometric analysis of duodenum in human fetus

Karabağ¹,

Erdoğan²,

Alsancak³

et al. 2021

Perinatal J

View full text Add to dashboard Cite

Objective The mucosa of the duodenum is lined by finger-like villi. In adults, the villus height to width ratio is about 4–5:1. The aim of this study is to evaluate the villus height to width ratio in the human fetus. Methods Eighty-one human fetal autopsies were included in the study. Three random villi were measured with the X and Y-axes. The statistical analysis was performed by Pearson correlation, Kolmogorov-Smirnov, chi-square, linear regression tests, and Student’s t-test. Results There were 29 female and 52 male fetuses. The age range was between 12 and 40 weeks of gestation. Of 81 fetuses, 2 were in the first trimester, 73 in the second trimester, and 6 in the third trimester. The mean villus height to width ratios in the first, second, and third trimesters were 2.75±0.37, 3.21±0.17, and 3.76±0.6, respectively. There was no correlation between the week of gestation and duodenum villus height to width ratio (p=0.080). The mean villus height to width ratios among females and males were 3.62±1.28 and 3.02±0.84, respectively (p=0.014). Conclusion In our study, villi were blunter and shorter in fetuses than in adults but not in children regardless of weeks of gestation compared to the literature. The gradual elongation of villi after birth may be attributed to environmental factors.

show abstract

Development of the Fetal Duodenum: A Postmortem Study

Cited by 10 publications

References 10 publications

Development of Fetal Intestinal Length during 2nd-Trimester in Normal and Pathologic Pregnancies

Development of Fetal Intestinal Length during 2nd-Trimester in Normal and Pathologic Pregnancies

Morphogenesis and Three‐Dimensional Movement of the Stomach During the Human Embryonic Period

Morphometric analysis of duodenum in human fetus

Contact Info

Product

Resources

About