Development of the hypothalamus: conservation, modification and innovation

Xie, Yuanyuan; Dorsky, Richard I.

doi:10.1242/dev.139055

Cited by 140 publications

(143 citation statements)

References 154 publications

(159 reference statements)

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“…It has been proposed that species-specific developmental programmes may result in “hypothalamic modules”, which can be gained or lost during evolution(Xie and Dorsky, 2017). One striking example of such a putative module is the posterior paraventricular organ surrounding the posterior recess, and which is housing the monoaminergic CSF-c cells.…”

Section: Discussionmentioning

confidence: 99%

“…Eventually the progenitors exit the cell cycle, migrate laterally and continue differentiation. Lineage specific combinations of transcription factors control the fate of the precursors (Biran et al, 2015; Burbridge et al, 2016; Muthu et al, 2016; Ware et al, 2014; Xie and Dorsky, 2017). The precise set of paracrine molecules and transcription factors required in time and space for each cell type is still a matter of investigations, as is the extent of evolutionary conservation.…”

Section: Introductionmentioning

confidence: 99%

“…The precise set of paracrine molecules and transcription factors required in time and space for each cell type is still a matter of investigations, as is the extent of evolutionary conservation. In zebrafish, the location of the serotonergic cells in the posterior hypothalamus suggests that their fate is favoured by posteriorising signals such as Wnt and Fgf (Kapsimali et al, 2004; Xie and Dorsky, 2017), and inhibited by anteriorising signals such as late Shh expression (Mathieu et al, 2002; Muthu et al, 2016). Indeed, Fgf ligands, receptors and downstream targets are expressed in the posterior zebrafish hypothalamus (Bosco et al, 2013; Herzog et al, 2004; Jackman et al, 2004; Liu et al, 2013; Reifers et al, 1998; Topp et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish

Reuter

Jaeckels

Kneitz

et al. 2018

Preprint

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system 33 34 2 Summary statement 35 36 This study highlights Fgf3 in a novel context where it is being part of a signalling 37 pathway of critical importance for development of hypothalamic monoaminergic cells 38 in zebrafish. Abstract 42 43 In most vertebrates, including zebrafish, the hypothalamic serotonergic cerebrospinal 44 fluid-contacting (CSF-c) cells constitute a prominent population. In contrast to the 45 hindbrain serotonergic neurons, little is known about the development and function of 46 these cells. Here, we identify Fibroblast growth factor (Fgf)3 as the main Fgf ligand 47 controlling the ontogeny of serotonergic CSF-c cells. We show that fgf3 positively 48 regulates the number of serotonergic CSF-c cells, as well as a subset of 49 dopaminergic and neuroendocrine cells in the posterior hypothalamus. Further, 50 expression of the ETS-domain transcription factor etv5b is downregulated after fgf3 51 impairment. Previous findings identified etv5b as critical for the proliferation of 52 serotonergic progenitors in the hypothalamus, and therefore we now suggest that 53 Fgf3 acts via etv5b during early development to ultimately control the number of 54 mature serotonergic CSF-c cells. Moreover, our analysis of the developing 55 hypothalamic transcriptome shows that the expression of fgf3 is upregulated upon 56 fgf3 loss-of-function, suggesting activation of a self-compensatory mechanism. 57 Together, these results highlight Fgf3 in a novel context as part of a signalling 58 pathway of critical importance for hypothalamic development.59 60 61 62Serotonin (5-hydroxytryptamine, 5-HT) is an ancient signalling molecule present in 63 the nervous system of animals from cnidarian and bilaterian lineages (Hay-Schmidt,

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish

Reuter

Jaeckels

Kneitz

et al. 2018

Preprint

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“…The developmental mechanisms regulating neuronal heterogeneity within hypothalamic nuclei are poorly understood compared to other CNS regions (Bedont et al, 2015;Burbridge et al, 2016;Xie and Dorsky, 2017).…”

Section: Introductionmentioning

confidence: 99%

Distinct temporal requirements for Sonic hedgehog signaling in development of the tuberal hypothalamus

Epstein

Corman

Zevallos

2018

Preprint

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“…Despite its behavioral importance, the development of the hypothalamus is poorly understood, largely because of its considerable anatomic and cellular complexity (Braak & Braak, 1992;Flament-Durand,1980;Lechan & Toni, 2000). Although recently some progress has been made in identifying extrinsic and intrinsic factors that control hypothalamic patterning and neurogenesis, much remains unknown Burbridge et al, 2016;Xie and Dorsky, 2017).…”

Section: Introductionmentioning

confidence: 99%

Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes

Newman

Wan

Wang

et al. 2017

Preprint

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Abstract:Although the hypothalamus functions as a master homeostat for many behaviors, little is known about the transcriptional networks that control its development. To investigate this question, we analyzed mice deficient for the Forkhead domain transcription factor Foxd1. Foxd1 is selectively expressed in neuroepithelial cells of the prethalamus and hypothalamus prior to the onset of neurogenesis, and is later restricted to neural progenitors of the prethalamus and anterior hypothalamus. During early stages of neurogenesis, we observed that Foxd1-deficient mice showed reduced expression of Six3 and Vax1 in anterior hypothalamus, but overall patterning of the prethalamus and hypothalamus is unaffected. After neurogenesis is complete, however, a progressive reduction and eventual loss of expression of molecular markers of the suprachiasmatic, paraventricular and periventricular hypothalamic is observed. These findings demonstrate that Foxd1 acts in hypothalamic progenitors to allow sustained expression of a subset of genes selectively expressed in mature neurons of the anterior hypothalamus. Highlights:1. Foxd1 is broadly expressed in neuroepithelial cells of the hypothalamus and prethalamus.2. Foxd1 mutants show severe defects in anterior hypothalamic development, although prethalamic development is only modestly affected.3. Loss of Foxd1 results does not affect initial patterning of the hypothalamus, but leads to a progressive loss of expression of markers specific to neurons of the suprachiasmatic, paraventricular and periventricular nuclei.4. Foxd1 regulates expression of multiple transcription factors expressed in developing anterior hypothalamus.peer-reviewed)

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Development of the hypothalamus: conservation, modification and innovation

Cited by 140 publications

References 154 publications

Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish

Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish

Distinct temporal requirements for Sonic hedgehog signaling in development of the tuberal hypothalamus

Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes

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