Development of the New Zealand White Rabbit Eye: I. Pre- and Postnatal Development of Eye Tunics

Abdo, Mohamed; Haddad, Seham; Emam, Mahmoud Abdelghaffar

doi:10.1111/ahe.12284

Cited by 15 publications

(12 citation statements)

References 25 publications

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“…24 No apparent histological differences in the eyes from PND1 to 14 were noted between this study and previous studies on the New Zealand white rabbit. 11 In addition, the timing of CALT appearance in this study was at PND11, the same as that in the New Zealand white rabbit. 21 However, the histological differences in postnatal ocular development between the New Zealand and Japanese white rabbits have not been fully investigated.…”

Section: Discussionmentioning

confidence: 90%

“…Furthermore, a recent study examined pre- and postnatal ocular histological development in New Zealand white rabbits. 11 Ocular histology during postnatal development in rabbits has not yet been sufficiently illustrated in the literature to fully inform histopathological examinations in nonclinical toxicology studies. In this study, we describe additional histological features of postnatal development of rabbit eyes and eyelids from the period immediately after birth to 6 weeks of age.…”

Section: Discussionmentioning

confidence: 99%

“…10 More recently, the histological features of postnatal ocular development in New Zealand white rabbits between gestational day 13 to postnatal day (PND) 14 was investigated. 11 However, despite the inclusion of figures illustrating ocular histological development in that article, there is still insufficient information available to fully inform the histopathological examination of ocular toxicity studies in juvenile rabbits. Currently, the histological characteristics of postnatal ocular development are widely dispersed in these literature, meaning that there is limited information available to support the design of, and histopathological examination of ocular toxicity studies in juvenile rabbits.…”

Section: Introductionmentioning

confidence: 99%

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Histological Features of Postnatal Development of the Eye in White Rabbits

2020

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Rabbits are frequently used in studies assessing the toxicity of ophthalmic drugs; however, the postnatal histological changes that occur in the rabbit eye have not been fully described. To characterize postnatal ocular development in white rabbits, a histological investigation of the eyes and eyelids was sequentially performed between postnatal days (PNDs) 1 and 42. The eyes opened during PNDs10 to 12. Significant changes prior to eyelid opening included the proliferation of uveal and optic nerve cells, regression of the lenticular vasculature, and thinning of the retina with a decreasing number of retinal cells. After eyelid opening, several significant changes occurred in the anterior segment, including thickening of the cornea and the development of lacrimation-related tissues in the eyelid and conjunctiva. Additionally, the differentiation of retinal layer-derived cells and optic nerve thickening occurred. The lens size continued to increase throughout the postnatal period. The histological structure of the eyes and eyelids was nearly mature by PNDs28 to 42. This study characterizes the postnatal changes in the histological features of the eyes in juvenile white rabbits, providing fundamental knowledge on the appropriate design of histological studies of the eyes in juvenile rabbits, particularly ophthalmic drug evaluations.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Histological Features of Postnatal Development of the Eye in White Rabbits

2020

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“…Rabbit models of ocular diseases are particularly useful in this context, especially considering that substantial knowledge already exists regarding the retinal circuitry, anatomy, and ophthalmologic pathogenesis in rabbits (Reichenbach et al, 1991a(Reichenbach et al, ,b,c, 1993(Reichenbach et al, , 1994Jones et al, 2011;Abdo et al, 2017). Rabbits possess relatively large eyes that share many anatomical features with humans.…”

Section: Gene Edited Rabbits For Translational Studies Of Ocular Diseasesmentioning

confidence: 99%

Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research

Zhang

Yang

et al. 2021

Front. Genet.

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The rabbit is a classic animal model for biomedical research, but the production of gene targeted transgenic rabbits had been extremely challenging until the recent advent of gene editing tools. More than fifty gene knockout or knock-in rabbit models have been reported in the past decade. Gene edited (GE) rabbit models, compared to their counterpart mouse models, may offer unique opportunities in translational biomedical research attributed primarily to their relatively large size and long lifespan. More importantly, GE rabbit models have been found to mimic several disease pathologies better than their mouse counterparts particularly in fields focused on genetically inherited diseases, cardiovascular diseases, ocular diseases, and others. In this review we present selected examples of research areas where GE rabbit models are expected to make immediate contributions to the understanding of the pathophysiology of human disease, and support the development of novel therapeutics.

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“…Because rabbit kits open their eyes at 10 d of age (Abdo et al, 2017) and eat solid food from 16 to 18 d (Gidenne and Fortun-Lamothe, 2002), before that time, light induces a difference in kit growth that is probably caused by the different milk yields of rabbit does; however, after that time, light induces weight difference in kits, which may be due to the change in their feed intake. As reported, there were several studies about light affecting feed intake of young rabbits.…”

Section: 4mentioning

confidence: 99%

Effect of lighting schedule, intensity, and colour on reproductive performance of rabbit does

Zhao

Qin

2021

World Rabbit Sci.

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In order to establish a lighting regime suitable for rabbit farms in East China, the effects of lighting schedule, intensity and colour on the reproductive performance of rabbit does were evaluated by three experiments, respectively. In experiment 1, does were exposed to different lighting schedules: 16L:8D-continuous, 16L:8D-18d (6 d before artificial insemination (AI) to 12 d post-AI), 16L:8D-6d (6 d before AI to the day of AI) and 12L:12D-continuous. In experiment 2, does were exposed to different light intensities: 40 lx, 60 lx, 80 lx and 120 lx. In experiment 3, does were exposed to different light colours: white, yellow, blue and red. For all experiments, conception rate, kindling rate and pre-weaning mortality were calculated; litter size at birth, litter weight at birth, litter size at weaning, litter weight at weaning and individual kit weight at weaning were recorded. Results showed that none of the reproductive parameters of does were affected by the application of 16L:8D-18d lighting schedule compared with the continuous 16L:8D group(P>0.05). Moreover, rabbits does exposed to 80 lx light performed as well as those under 120 lx light in conception rate, kindling rate, litter size (total and alive) at birth and litter weight at birth (P>0.05). Furthermore, the exposures of 60 lx and 80 lx light were beneficial for litter weight at weaning. In addition, red light had a positive effect, as it led to a larger litter size and litter weight at weaning and lower pre-weaning mortality than white light (P<0.05). In summary, a 16L:8D photoperiod with 80 lx red light from 6 d before AI to 12 d post-AI is recommended for use in breeding of rabbit does according to our results.

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Development of the New Zealand White Rabbit Eye: I. Pre- and Postnatal Development of Eye Tunics

Cited by 15 publications

References 25 publications

Histological Features of Postnatal Development of the Eye in White Rabbits

Histological Features of Postnatal Development of the Eye in White Rabbits

Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research

Effect of lighting schedule, intensity, and colour on reproductive performance of rabbit does

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