Development of the origin of the coronary arteries, a matter of ingrowth or outgrowth?

Bogers, Ad J.J.C.; Groot, Adriana C. Gittenberger‐de; Poelmann, R. E.; Péault, Bruno; Huysmans, Hans A.

doi:10.1007/bf00305118

Cited by 263 publications

(182 citation statements)

References 14 publications

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“…Embryological studies have shown that position of the proximal coronary arteries is dependent upon where the coronary arteries grow into, rather than out of the aorta. 16 It is possible that these two groups of anomaly may therefore be embryologically related.…”

Section: Embryologymentioning

confidence: 99%

Quadricuspid aortic valves

Timperley

Milner

Marshall

et al. 2002

Clinical Cardiology

120

136

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Summary:Quadricuspid aortic valves (QAV) are a rare but well recognized cause of significant aortic regurgitation. The first case was found reported in 1862. Since then there have been 110 reported cases of QAV and we report 4 more. Previously, these were diagnosed at the time of surgery or postmortem examination. With advances in echocardiography, including harmonic imaging, and also the advent of transesophageal echocardiography, more cases are being diagnosed prior to surgery. We describe four more cases, three diagnosed preoperatively and one at the time of surgery, and then review the previously reported cases. Of the 114 cases reported, 46 had the aortic valve replaced, most commonly in the 5th and 6th decade of life. Hurwitz and Roberts classified quadricuspid valves according to the size of the leaflets. It has previously been believed that QAVs with four equal sized leaflets were less likely to develop significant aortic regurgitation; however, on review of the available cases, this would not appear to be the case. The preoperative diagnosis of QAVs is important as they can be associated with abnormally placed coronary ostium. Of the 114 cases reported, there are 10 reports of abnormally placed ostia. There has been at least one reported case of death occurring because of obstruction of an abnormally placed right coronary ostium by a prosthetic aortic valve.

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Section: Embryologymentioning

confidence: 99%

Quadricuspid aortic valves

Timperley

Milner

Marshall

et al. 2002

Clinical Cardiology

120

136

View full text Add to dashboard Cite

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“…The establishment of the definitive coronary trunks is a tightly controlled event (Hutchins et al 1988 ;Waldo et al 1990) which occurs by interaction between the capillaries existing around the embryonic bulbus and the aortic root (Bogers et al 1989 ;Waldo et al 1990 ;Poelmann et al 1993). Our hypothesis is that, as appears to occur in other areas of the developing heart (Icardo & Sanchez de Vega, 1991 ;Icardo et al 1995), the signals which regulate specific morphogenetic events are overridden or lost in the iv\iv mice.…”

Section: mentioning

confidence: 99%

Origin and course of the coronary arteries in normal mice and in iv/iv mice

Icardo

Colvée

2001

Journal of Anatomy

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This paper reports on the origin and distribution of the coronary arteries in normal mice and in mice of the iv\iv strain, which show situs inversus and heterotaxia. The coronary arteries were studied by direct observation of the aortic sinuses with the scanning electron microscope, and by examination of vascular corrosion casts. In the normal mouse, the left and right coronaries (LC, RC) arise from the respective Valsalva sinus and course along the ventricular borders to reach the heart apex. Along this course the coronary arteries give off small branches at perpendicular or acute angles to supply the ventricles. The ventricular septum is supplied by the septal artery, which arises as a main branch from the right coronary. Conus arteries arise from the main coronary trunks, from the septal artery and\or directly from the Valsalva sinus. The vascular casts demonstrate the presence of intercoronary anastomoses. The origin of the coronary arteries was found to be abnormal in 84 % of the iv\iv mice. These anomalies included double origin, high take-off, slit-like openings and the presence of a single coronary orifice. These anomalies occurred singly or in any combination, and were independent of heart situs. The septal artery originated from RC in most cases of situs solitus but originated predominantly from LC in situs inversus hearts. Except for this anomalous origin no statistical correlation was found between the coronary anomalies and heart situs or a particular mode of heterotaxia. The coronary anomalies observed in the iv\iv mice are similar to those found in human hearts. Most coronary anomalies appear to be due to defective connections between the aortic root and the developing coronaries. iv\iv mice may therefore constitute a good model to study the development of similar anomalies in the human heart.

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“…It was initially assumed that the coronary arteries were formed by outgrowths from the aorta, however, this has never been documented (Ando et al, 2004). Bogers et al (1989) reported that coronary arteries develop through ingrowth of the vessels by demonstrating that the coronary arteries could be identified in the walls of the aortic sinuses before the formation of the coronary orifices. It is now largely accepted that the proximal coronary arteries develop from a complex capillary network derived from epicardial mesenchyme and not as sprouting and branching outgrowths of the aorta (Santhoshkumar et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Morphologic Relationship Between the Coronary Arteries During Fetal Development

et al. 2017

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SINGH, S.; AJAYI, N.; LAZARUS, L. & SATYAPAL, K. S.Morphologic relationship between the coronary arteries during fetal development. Int. J. Morphol., 35(4):1197Morphol., 35(4): -1202Morphol., 35(4): , 2017. SUMMARY:A detailed understanding of the coronary arteries is of paramount importance in the management of coronary arterial diseases. The arterial supply to the heart originates from right (RCA) and left (LCA) coronary arteries which form an oblique inverted crown within the atrioventricular groove. This study aimed to document the embryologic relationship between the RCA and the LCA including their lengths, diameters, branching patterns and arterial dominance in fetuses. Forty-one human fetal heart specimens with an age range of 13.13 to 26.95 weeks were dissected at the Department of Clinical Anatomy, University of Kwazulu-Natal, Durban, South Africa. The RCA arose from the right aortic sinus and was dominant in all the specimens. The LCA was classified into types according to their branching pattern. The bifurcation, trifurcation and quadrifurcation of the LCA occurred in 68.3 %, 29.3 % and 2.4 % of hearts, respectively. The mean lengths of the RCA and LCA were 0.98±0.54 mm and 1.83±0.77 mm, respectively. The mean external diameters of the RCA and LCA were 0.38±0.12 mm and 0.49±0.17 mm, respectively. There was a significant correlation between the RCA and LCA length and the fetal age which is indicative of significant changes in the coronary vasculature with fetal growth.

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Development of the origin of the coronary arteries, a matter of ingrowth or outgrowth?

Cited by 263 publications

References 14 publications

Quadricuspid aortic valves

Quadricuspid aortic valves

Origin and course of the coronary arteries in normal mice and in iv/iv mice

Morphologic Relationship Between the Coronary Arteries During Fetal Development

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