Development of the serotonergic system in the rat embryo: An immunocytochemical study

Wallace, James A.; Lauder, Jean M.

doi:10.1016/0361-9230(83)90144-2

Cited by 379 publications

(260 citation statements)

References 55 publications

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“…Expression is restricted to two bilateral longitudinal hindbrain domains at the level of rhombomeres r1-r3 and r5-r8. These two domains, classically referred to as rostral and caudal domains, eventually give rise to all of the 5-HTsynthesizing neurons in the rodent brain (Levitt and Moore, 1978;Lidov and Molliver, 1982;Wallace and Lauder, 1983;Pattyn et al, 2003). Expression of Pet-1 is first seen in the rostral domain, followed 1-2 d later by expression in the caudal domain.…”

Section: Z Expression Recapitulates the Temporal Expression Pattermentioning

confidence: 99%

A Differentially AutoregulatedPet-1Enhancer Region Is a Critical Target of the Transcriptional Cascade That Governs Serotonin Neuron Development

2005

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Section: Z Expression Recapitulates the Temporal Expression Pattermentioning

confidence: 99%

A Differentially AutoregulatedPet-1Enhancer Region Is a Critical Target of the Transcriptional Cascade That Governs Serotonin Neuron Development

2005

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“…Previous light microscopy studies have shown that, after reaching the neocortex, serotonergic afferents form two bands, one in the marginal zone (MZ) above the cortical plate and the other below the cortical plate, before they massively invade the cortical plate itself (Lidov and Molliver, 1982;Wallace and Lauder, 1983;Bruning et al, 1997;Verney et al, 2002). In the mouse and rat, the first serotonergic fibers in the developing neocortex appear around embryonic day 16 -17 (E16 -17) (Wallace and Lauder, 1983;Bruning et al, 1997). Because early serotonergic projections target the MZ, it has been suggested that they may play an important role in cortical development (Whitaker-Azmitia et al, 1996;Persico et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Early Serotonergic Projections to Cajal-Retzius Cells: Relevance for Cortical Development

Janušonis¹,

Glunčić²,

Rakić³

2004

J. Neurosci.

135

123

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Although the serotonergic system plays an important role in various neurological disorders, the role of early serotonergic projections to the developing cerebral cortex is not well understood. Because serotonergic fibers enter the marginal zone (MZ) before birth, it has been suggested that they may influence cortical development through synaptic contacts with Cajal-Retzius (CR) cells. We used immunohistochemistry combined with confocal and electron microscopy to show that the earliest serotonergic projections to the MZ form synaptic contacts with the somata and proximal dendrites of CR cells as early as embryonic day 17. To elucidate the functional significance of these early serotonergic contacts with CR cells, we perturbed their normal development by injecting pregnant mice with 5-methoxytryptamine. Lower reelin levels were detected in the brains of newborn pups from the exposed animals. Because reelin plays an important role in the cortical laminar and columnar organization during development, we killed some pups from the same litters on postnatal day 7 and analyzed their presubicular cortex. We found that the supragranular layers of the presubicular cortex (which normally display a visible columnar deployment of neurons) were altered in the treated animals. Our results suggest a mechanism of how serotonergic abnormalities during cortical development may disturb the normal cortical organization; and, therefore, may be relevant for understanding neurological disorders in which abnormalities of the serotonergic system are accompanied by cortical pathology (such as autism).

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“…Some studies on mouse embryo cultures treated with serotonin suggest an improved development of serotoninergic cells in the nervous tissue and of cells of the nasal prominence, epithelium covering the eye, optic vesicle, and oral cavity (10,(29)(30)(31)(32)(33). These findings indicate that serotonin plays a role in the control of the epithelial-mesenchymal interactions during craniofacial morphogenesis (26).…”

Section: Discussionmentioning

confidence: 99%

Neonatal administration of citalopram delays somatic maturation in rats

Deiró

Manhães-de-Castro

Cabral-Filho³

et al. 2004

Braz J Med Biol Res

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We investigated the somatic maturation of neonate rats treated during the suckling period with citalopram, a selective serotonin reuptake inhibitor. Groups with 6 male neonates were randomly assigned to different treatments 24 h after birth. Each litter was suckled by one of the dams until the 21st postnatal day. Body weight, head axis and tail length were measured daily from the 1st to the 21st postnatal day. Time of ear unfolding, auditory conduit opening, incisor eruption, and eye opening was determined. Pups received 5 mg (Cit5), 10 mg (Cit10) or 20 mg/kg (Cit20) citalopram sc, or saline (0.9% NaCl, w/v, sc). Compared to saline, body weight was lower (24.04%, P < 0.01) for Cit10 from the 10th to the 21st day and for Cit20 from the 6th to the 21st day (38.19%, P < 0.01). Tail length was reduced in the Cit20 group (15.48%, P < 0.001) from the 8th to the 21st day. A reduction in mediolateral head axis (10.53%, P < 0.05) was observed from the 11th to the 21st day in Cit10 and from the 6th to the 21st day in Cit20 (13.16%, P < 0.001). A reduction in anteroposterior head axis was also observed in the Cit20 group (5.28%, P < 0.05) from the 13th to the 21st day. Conversely, this axis showed accelerated growth from the 12th to the 21st day in the Cit5 group (13.05%, P < 0.05). Auditory conduit opening was delayed in the Cit5 and Cit20 groups and incisor eruption was delayed in all citalopram groups. These findings show that citalopram injected during suckling to rats induces body alterations and suggest that the activity of the serotoninergic system participates in growth mechanisms.

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Development of the serotonergic system in the rat embryo: An immunocytochemical study

Cited by 379 publications

References 55 publications

A Differentially AutoregulatedPet-1Enhancer Region Is a Critical Target of the Transcriptional Cascade That Governs Serotonin Neuron Development

A Differentially AutoregulatedPet-1Enhancer Region Is a Critical Target of the Transcriptional Cascade That Governs Serotonin Neuron Development

Early Serotonergic Projections to Cajal-Retzius Cells: Relevance for Cortical Development

Neonatal administration of citalopram delays somatic maturation in rats

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