Development of the zebrafish lateral line

Ghysen, Alain; Dambly‐Chaudière, Christine

doi:10.1016/j.conb.2004.01.012

Cited by 245 publications

(167 citation statements)

References 37 publications

Supporting

Mentioning

160

Contrasting

Unclassified

Order By: Relevance

“…The lateral-line system, which underlies a fish's sensitivity to predators, prey, and obstacles, also has hair cells whose hair bundles are precisely oriented with respect to the body axes (10,11). Labeling of the hair bundles in ru622 mutants disclosed that the vectorial orientation of these cells was normal ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear

Asai

Chan

Starr

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The development of the vertebrate inner ear depends on the precise expression of fibroblast growth factors. In a mutagenesis screen for zebrafish with abnormalities of inner-ear development and behavior, we isolated a mutant line, ru622, whose phenotypic characteristics resembled those of null mutants for the gene encoding fibroblast growth factor 8 (Fgf8): an inconsistent startle response, circular swimming, fused otoliths, and abnormal semicircular canals. Positional cloning disclosed that the mutant gene encodes the transcriptional corepressor Atrophin2. Both the Fgf8 protein and zebrafish ''similar expression to fgf genes'' protein (Sef), an antagonist of fibroblast growth factors induced by Fgf8 itself, were found to be overexpressed in ru622 mutants. We therefore hypothesized that an excess of Sef eliminates Fgf8 signals and produces an fgf8 null phenotype in ru622 mutants. In support of this idea, we could rescue larvae whose atrophin2 expression had been diminished with morpholinos by reducing the expression of Sef as well. We propose that Atrophin2 plays a role in the feedback regulation of Fgf8 signaling. When mutation of the atrophin2 gene results in the overexpression of both Fgf8 and Sef, the excessive Sef inhibits Fgf8 signaling. The resultant imbalance of Fgf8 and Sef signals then underlies the abnormal aural development observed in ru622.auditory system ͉ hearing ͉ vestibular system T he complex structure of the inner ear is largely conserved across vertebrate species. In an adult animal, the inner ear contains several distinct sensory epithelia that are variously dedicated to the detection of linear acceleration, angular acceleration, and sound. Each sensory epithelium includes mechanosensory hair cells that are separated by nonsensory supporting cells and innervated by afferent terminals from the eighth cranial nerve (reviewed in ref.

show abstract

Section: Resultsmentioning

confidence: 99%

Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear

Asai

Chan

Starr

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…The migration of the posterior lateral line primordium gives rise to the development of the posterior lateral line with the neuromasts on the trunk and tail. Towards the end of zebrafish embryogenesis, the lateral line comprises 7-8 neuromasts regularly spaced between the ear and the tip of the tail (Metcalfe, 1985(Metcalfe, , 1989Metcalfe et al, 1985;Gompel et al, 2001;Itoh and Chitnis, 2001;Dambly-Chaudiere et al, 2003;Ghysen and Dambly-Chaudiere, 2004). The heterogeneous labelling of the primordium by the CB701 and CB403 markers revealed that the primordium is dynamically pre-patterned, and that clusters of cells corresponding to presumptive neuromasts are already defined within the primordium several hours before their deposition (Gompel et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Molecular cloning and embryonic expression of zebrafish PCSK5 co‐orthologues: Functional assessment during lateral line development

Chitramuthu

Baranowski

Cadieux

et al. 2010

Developmental Dynamics

View full text Add to dashboard Cite

Pro-protein convertase subtilisin/kexin 5 (PC5, also known as PC6) is a member of the subtilisin-like superfamily of serine proteases implicated in the maturation of latent precursor proteins into their functionally active derivatives. To investigate the functional roles, we have cloned the cDNA sequences encoding two candidate zebrafish PC5 convertases (designated as PCSK5.1 and PCSK5.2) co-orthologous to the single PC5 encoding gene (PCSK5) found in mammals. Both display syntenic correspondence to the human PCSK5 gene. Overall gene architecture has been conserved across species. While PC5.1 mRNA expression is very discrete within the otic vesicle and lateral line neuromasts, PC5.2 transcripts are more ubiquitously expressed within the central nervous system together with specific localization in various organs including liver, intestine, and otic vesicle. Zebrafish PC5.1-deficient embryos display abnormal neuromast deposition within the lateral line system and lack a normal touch response, consistent with the known sensory role that the lateral line plays in spatial awareness and sensing the environment.

show abstract

“…Similarly, a subpopulation of prechordal cells located under the anterior brain region migrates ventrally and posteriorly over the yolk cell and differentiates into hatching gland cells (Kimmel, 1993). Migration is also essential for the formation of the posterior lateral line of sensory hair cells, as a cell primordium migrates down the side of the body along the horizontal myoseptum and deposits clusters of cells that will form neuromasts (Ghysen and Dambly-Chaudiere, 2004). Thus, cell migration not only helps to shape the basic embryonic body plan, as in the case of dorsal convergence, but also contributes to its further refinement through the formation of specific tissues and organs.…”

Section: Introductionmentioning

confidence: 99%

Analysis of axis induction mutant embryos reveals morphogenetic events associated with zebrafish yolk extension formation

Gingerich

Lindeman

Putiri

et al. 2006

Developmental Dynamics

View full text Add to dashboard Cite

We analyze patterning and morphogenetic events during somitogenesis in hecate mutant embryos, which exhibit early axis induction defects. The posterior region, in the absence of a dorsal axis, is capable of forming organized gene expression patterns. The aberrant morphogenesis of mutant embryos is associated with anteriorly directed cell movements, underlying the enveloping layer, from the posterior region. In both wild-type and mutant embryos, these changes result in an accumulation of cells, whose location correlates with a constriction in the posterior yolk cell, which in the wild-type corresponds to the yolk extension. The region encompassing the constriction corresponds to a region of expression of zangptl2 in the yolk syncytial layer, which expands anteriorly together with the anteriorly migrating tail bud-derived cell population.

show abstract

Development of the zebrafish lateral line

Cited by 245 publications

References 37 publications

Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear

Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear

Molecular cloning and embryonic expression of zebrafish PCSK5 co‐orthologues: Functional assessment during lateral line development

Analysis of axis induction mutant embryos reveals morphogenetic events associated with zebrafish yolk extension formation

Contact Info

Product

Resources

About