2014
DOI: 10.1021/am5064298
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Development of Therapeutic Au–Methylene Blue Nanoparticles for Targeted Photodynamic Therapy of Cervical Cancer Cells

Abstract: Photodynamic therapy (PDT) involves the cellular uptake of a photosensitizer (PS) combined with oxygen molecules and light at a specific wavelength to be able to trigger cancer cell death via the apoptosis pathway, which is less harmful and has less inflammatory side effect than necrosis. However, the traditional PDT treatment has two main deficiencies: the dark toxicity of the PS and the poor selectivity of the cellular uptake of PS between the target cells and normal tissues. In this work, methylene blue (MB… Show more

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Cited by 91 publications
(100 citation statements)
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“…Although some GQDs can enter cells without modification (32), many graphene quantum dots are not able to cross cancer cell membranes (33)(34)(35)(36)(37)(38). Similarly, methylene blue can also exhibit reduced membrane permeability in cancer cell lines (18,(39)(40)(41)(42). Our data (Fig.…”
Section: Cell Uptake Measurementmentioning
confidence: 72%
“…Although some GQDs can enter cells without modification (32), many graphene quantum dots are not able to cross cancer cell membranes (33)(34)(35)(36)(37)(38). Similarly, methylene blue can also exhibit reduced membrane permeability in cancer cell lines (18,(39)(40)(41)(42). Our data (Fig.…”
Section: Cell Uptake Measurementmentioning
confidence: 72%
“…For measuring the photothermal performance, a suspension (1 ml) containing the PPy-MB NPs with different concentrations (10,20,30,50,70, and 100 mg ml À1 ) was put in a 12-well plate.…”
Section: Photothermal Testmentioning
confidence: 99%
“…10 Besides, MB is one of few PSs which were approved by FDA. 11,12 Generally, the ROS generated by MB induces cell death following apoptosis pathway that is less harmful to the patient than necrosis pathway.…”
Section: Introductionmentioning
confidence: 99%
“…PDT showed initial success in the treatment of malignant diseases, including skin tumors (3), cutaneous T-cell lymphoma (4) and cervical cancer (5,6), and precancerous lesions, including Bowen's disease (7,8) and Barrett's oesophagus (9). In recent years, PDT has also been used for the treatment of vulgaris, leishmaniasis, acne and bacterial, fungal and viral infections (10)(11)(12).…”
Section: Introductionmentioning
confidence: 99%