Development of thin-film hydroxyapatite coatings with an intermediate shellac layer produced by dip-coating process on Ti6Al4V implant materials

Ritwik, A.; Saju, K. K.; Vengellur, Ajith; Saipriya, P. P.

doi:10.1007/s11998-021-00549-y

Cited by 13 publications

(10 citation statements)

References 24 publications

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“…HA, the main component of the composite with excellent biological activity, played a key role in the process of bone conduction and new bone formation. In fact, HA has been widely used as implant coating in many previous studies to promote bone generation [ 26 ]. It was demonstrated that HA coating on the surface of metal implants could significantly increase bone conductivity with the contact area percentage of new bone formation to nearly 100% [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

Osteogenesis Performance of Boronized Ti6Al4V/HA Composites Prepared by Microwave Sintering: In Vitro and In Vivo Studies

et al. 2022

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The boronized Ti6Al4V/HA composite is deemed to be an important biomaterial because of its potential remarkable mechanical and biological properties. This paper reports the osteogenesis performance of the boronized Ti6Al4V/HA composite, which was prepared by microwave sintering of powders of Ti6Al4V, hydroxyapatite (HA), and TiB2 in high-purity Ar gas at 1050 °C for 30 min, as dental implant based on both cell experiments in vitro and animal experiments in vivo. The comparison between the boronized Ti6Al4V/HA composite and Ti, Ti6Al4V, and boronized Ti6Al4V in the terms of adhesion, proliferation, alkaline phosphate (ALP) activity, and mineralization of MG-63 cells on their surfaces confirmed that the composite exhibited the best inductive osteogenesis potential. It exerted a more significant effect on promoting the early osteogenic differentiation of osteoblasts and exhibited the maximum optical density (OD) value in the MTT assay and the highest levels of ALP activity and mineralization ability, primarily ascribed to its bioactive HA component, porous structure, and relatively rough micro-morphology. The in vivo study in rabbits based on the micro-computed tomography (micro-CT) analysis, histological and histomorphometric evaluation, and biomechanical testing further confirmed that the boronized Ti6Al4V/HA composite had the highest new bone formation potential and the best osseointegration property after implantation for up to 12 weeks, mainly revealed by the measured values of bone volume fraction, bone implant contact, and maximum push-out force which, for example, reached 48.64%, 61%, and 150.3 ± 6.07 N at the 12th week. Owing to these inspiring features, it can serve as a highly promising dental implant.

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Section: Resultsmentioning

confidence: 99%

Osteogenesis Performance of Boronized Ti6Al4V/HA Composites Prepared by Microwave Sintering: In Vitro and In Vivo Studies

et al. 2022

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“…Moreover, the produced HA layers exhibited close mechanical parameters to cortical bone (H = 0.29 GPa, Young’s modulus = 25.96 GPa) and high adhesion force = 169.93 mN for the TNF6C/HA sample. Ritwik et al [ 102 ] produced a thin layer (30 µm) of hydroxyapatite on a Ti6Al4V substrate using a dip-coating process. They used shellac (a natural resin) as an intermediate coating.…”

Section: Discussionmentioning

confidence: 99%

“…The researchers showed that the deposition of a shellac layer between the HA and the Ti6Al4V substrate increases the adhesion force from 1.08 MPa (Ti6Al4V/HA) to 7.14 MPa (Ti6Al4V/Shellac/HA). The average surface roughness (R a ) values measured were 0.93 µm [ 102 ]. The cathodic deposition of hydroxyapatite, which we optimized, allowed us to obtain thinner hydroxyapatite layers (from 10 µm to 20 µm, depending on the type of intermediate coating used) and two to three times lower roughness.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Cathodic Electrodeposition Effectiveness of the Hydroxyapatite Layer Used in Surface Modification of Ti6Al4V-Based Biomaterials

et al. 2022

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The important issue associated with the design and the fabrication of the titanium and titanium alloy implants is the increase of their biointegration with bone tissue. In the presented paper, the research results concerning the conditions used in the cathodic deposition of hydroxyapatite on the surface Ti6Al4V substrates primarily modified by the production of TiO2 nanoporous coatings, TiO2 nanofibers, and titanate coatings, are discussed. Despite excellent biocompatibility with natural bone tissue of materials based on hydroxyapatite (HA), their poor adhesion to the substrate caused the limited use in the implants’ construction. In our works, we have focused on the comparison of the structure, physicochemical, and mechanical properties of coating systems produced at different conditions. For this purpose, scanning electron microscopy images, chemical composition, X-ray diffraction patterns, infrared spectroscopy, wettability, and mechanical properties are analyzed. Our investigations proved that the intermediate titanium oxide coatings presence significantly increases the adhesion between the hydroxyapatite layer and the Ti6Al4V substrate, thus solving the temporary delamination problems of the HA layer.

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“…Coated thin films are typically prepared using chemical vapor deposition, , physical vapor deposition, , dip-coating, − and spin coating, − while free-standing thin films are usually fabricated using extrusion–stretching and spin-coating techniques . A free-standing thin film is defined as a film that does not adhere to a support such as a substrate or a wall surface to maintain a film structure.…”

Section: Introductionmentioning

confidence: 99%

Free-Standing Porous and Nonporous Polyethylene Thin Films Using Spin Coating: An Alternate to the Extrusion–Stretching Process

Saleem

Baig

Luyt

et al. 2023

ACS Appl. Polym. Mater.

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Spin coating is widely used in the preparation of thin films as it yields reproducible results with uniform surface and controlled thickness. However, free-standing thin films of polyolefins have never been produced using spin coating as the coated films do not have sufficient strength to maintain their integrity without a supporting layer or substrate. Herein, we report free-standing thin films of polyolefins such as polyethylene with varying thickness ranging from 5 to 20 μm. In one such combination, 30% porosity, 5 MPa tensile strength, and 7 μm thickness were achieved. These films can be used as hydrophobic coating, filtration membranes, and oil-sorbents.

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Development of thin-film hydroxyapatite coatings with an intermediate shellac layer produced by dip-coating process on Ti6Al4V implant materials

Cited by 13 publications

References 24 publications

Osteogenesis Performance of Boronized Ti6Al4V/HA Composites Prepared by Microwave Sintering: In Vitro and In Vivo Studies

Osteogenesis Performance of Boronized Ti6Al4V/HA Composites Prepared by Microwave Sintering: In Vitro and In Vivo Studies

Evaluation of the Cathodic Electrodeposition Effectiveness of the Hydroxyapatite Layer Used in Surface Modification of Ti6Al4V-Based Biomaterials

Free-Standing Porous and Nonporous Polyethylene Thin Films Using Spin Coating: An Alternate to the Extrusion–Stretching Process

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