Development of Ti-15Zr-Mo alloys for applying as implantable biomedical devices

Abstract

In this study, the effect of molybdenum content in Ti-15Zr-based alloys (wt%) was analyzed in terms of crystalline structure, microstructure, selected mechanical properties, and cytotoxicity. The samples were produced by argon arc-melting followed by hot rolling and heat treatment processes. The crystalline structure and microstructure were dependent of both alloying elements (zirconium and molybdenum). Ti-15Zr alloy displayed only laths of a 0 phase, while the alloys up to Ti-15Zr-10Mo exhibited different proportions of a 0 , a", and b phases. Molybdenum content higher than 12.5 wt% fully stabilized the b phase. Vickers microhardness values of Ti-15Zr-Mo alloys were higher than those of CP-Ti due to solid solution and phase precipitation strengthening. Young's modulus values of Ti-15Zr-Mo alloys were lower than those of CP-Ti due to b phase stabilization. Cytotoxicity levels of Ti-15Zr-Mo alloys were within a tolerable range for biomedical purposes. In addition, we observed molybdenum content in Ti-15Zr-based alloys promoted an increase on pre-osteoblast adhesion up to 3 h of adhesion's time. Thus, Ti-15Zr-15Mo alloy presented better combination of properties than some traditional metallic biomaterials.

Effect of Thermo-Mechanical Treatments on the Microstructure and Mechanical Properties of the Metastable β-type Ti-35Nb-7Zr-5Ta Alloy

“…Interestingly, the alloy is located in the β+ω region lying below the β/β+ω nominal boundary, indicated by a solid line in Figure 1, despite the fact that it is actually a single β-phase alloy as further confirmed by XRD and TEM analyses. In this particular case, Zr does not follow the general feature of a neutral element, but instead it behaves as β-stabilizer when alloyed with other β-type elements, such as Nb and Ta 9,10 . Thus, the coalloying of Zr shifts the β/β+ω phase boundary to the further lower compositional region of β-stabilizing elements (i.e.…”

Laser-Assisted Surface Texturing of Ti/Zr Multilayers for Mesenchymal Stem Cell Response

“…In XRD pattern for as-deposited 30×(Ti/Zr)/Si multilayer system was identified both α-Ti and β-Ti phases (Figure 6a) at the following crystalline orientations α-Ti(100), β-Ti(110), α-Ti(102) and β-Ti(200) [28]. In this case, zirconium played a role as a β-stabiliser element, which induced the formation of β-Ti phases during the deposition of thin Ti and Zr layers [4]. Comparing the XRD patterns obtained for as-deposited and after laser processing of Ti/Zr multilayer thin film, it was observed that diffraction lines did not change positions.…”

“…Surface composition and morphology regulate surface bioactivity and other biofunctionalities, in terms of the adsorption of proteins on the material surface, which is determinant for the subsequent processes of cell growth, differentiation, and extracellular matrix formation [1][2][3]. Titanium-based materials are nowadays well integrated into the body, due to high specific strength, excellent corrosion resistance, and good biocompatibility [4,5]. Currently, one of the main tasks is development of the Ti-based alloys with a high concentration of β-stabilizer elements (β phase of titanium), and to provide compliance between the elasticity of the implant and the surrounding hard tissues (bones).…”

Development of novel Ti-Mo-Mn alloys for biomedical applications

“…The arc melting technique is widely used to produce high melting titanium alloys. Several works in the literature use this technique to produce metallic alloys [30][31][32] . In these works alloys with the tantalum elements in the chemical composition, melting point exceeding 3,273 K are satisfactorily produced [33][34][35] .…”