Development of Topical Nanoemulgel Using Combined Therapy for Treating Psoriasis

Bhardwaj, S. B.; Gaur, Praveen Kumar; Tiwari, Ashutosh

doi:10.1089/adt.2021.112

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…The pH of the developed nanoemulgel was measured using a digital pH meter [23]. Prior to analysis, the pH meter was calibrated using buffer solutions of pH values 4, 7, and 9.…”

Section: Characterization Of Qct@ng Measurement Of Phmentioning

confidence: 99%

Design-of-Experiments (DoE)-Assisted Fabrication of Quercetin-Loaded Nanoemulgel and Its Evaluation against Human Skin Cancer Cell Lines

et al. 2022

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Background: Quercetin (QCT) is a natural polyphenolic flavonoid showing great potential in the treatment of skin cancer. However, its use is limited owing to its poor water solubility, poor absorption, quick metabolism and excretion, as well as low stability. Preparation of nanoemulgel has been proven to be an effective approach to deliver the drugs topically due to various advantages associated with it. Objectives: This study aimed to prepare stable nanoemulgel of QCT using a Design-of-Experiments (DoE) tool for optimization, to characterize and to assess its in vivo toxicity and efficacy against human cancer cell lines in vitro. Methods: An ultrasonication emulsification method was used for the preparation of QCT-loaded nanoemulsion (QCT@NE). Box–Behnken design was used for the optimization of developed nanoemulgel. Then, in vitro characterization of prepared nanoemulsion was performed using Fourier Transform-Infra Red (FT-IR) spectroscopy, Scanning Electron Microscopy (SEM), particle size analysis, determination of zeta potential and entrapment efficiency (%EE). Further, the developed QCT-loaded nanoemulgel (QCT@NG) was characterized in vitro using texture profile analysis, viscosity and pH determination. Eventually, the cell cytotoxicity studies of the prepared nanoemulgel were performed on the skin cancer cell lines A431 followed by an acute toxicity and skin irritation study on male wistar rats in vivo. Results: The developed QCT@NE was found to be nanometric in size (173.1 ± 1.2 nm) with low polydispersity index (0.353 ± 0.13), zeta potential (−36.1 ± 5.9 mV), and showed good %EE (90.26%). The QCT@NG was found to be substantially more effective against the human skin carcinoma (A431) cell lines as compared to plain QCT with IC50 values of 108.5 and 579.0 µM, respectively. Skin irritation study showed no sign of toxicity and ensured safety for topical application. Hematological analysis revealed no significant differences between the treatment and control group in any biochemical parameter. In the nanoemulgel treatment group, there were no discernible differences in the liver enzymes, bilirubin, hemoglobin, total leukocyte and platelet counts as compared to the control group. Conclusions: The optimized QCT@NG was found to be an ideal and promising formulation for the treatment of skin cancer without showing skin irritation and organ toxicity.

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“…The pH of the developed nanoemulgel was measured using a digital pH meter [23]. Prior to analysis, the pH meter was calibrated using buffer solutions of pH values 4, 7, and 9.…”

Section: Characterization Of Qct@ng Measurement Of Phmentioning

confidence: 99%

Design-of-Experiments (DoE)-Assisted Fabrication of Quercetin-Loaded Nanoemulgel and Its Evaluation against Human Skin Cancer Cell Lines

et al. 2022

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“…30,31,99,100 It is also known as xanthotoxin and is a pigmentation agent used in the treatment of psoriasis cutaneous, T-cell lymphoma, and vitiligo. [101][102][103] Methoxsalen is a potent inhibitor of CYP2A6 nicotine metabolism in the liver microsomes of adult male ICR mouse with a Ki of 0.32±0.03 µM. 104 An animal study demonstrated that the administration of methoxsalen intraperitoneally significantly enhanced Cmax of nicotine, prolonged the plasma half-life of nicotine and increased its area under the curve compared to intraperitoneal vehicle treatment.…”

Section: Methoxsalenmentioning

confidence: 99%

Untitled

2022

TJNPR

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Nicotine use disorders, which are typically acquired through tobacco smoking, are a global problem and a leading cause of preventable deaths. Unfortunately, the available therapies intended for tobacco smoking cessation have varying efficacy among smokers in addition to some adverse effects observed. These factors, alongside the cost of such therapies deemed as a financial burden by some, contribute to the failure to meet patients" needs. This necessitates the many studies being conducted on the possible use of natural products in the treatment of nicotine use disorders to address such issues. Therefore, this review aims to discuss published data documenting the effects of plant extracts and bioactive compounds on nicotine-induced reactions and nicotine use disorders by looking into the different effects, possible mechanisms, and the putative targets of these selected natural products. A total of 21 natural products and bioactive compounds were obtained from searches across PubMed, Ovid Medline and Scopus databases which comprised of studies performed in vitro and in vivo as well as human trials. These data suggest that these natural products may have the potential to be utilized to treat nicotine use disorders. Undoubtedly, more detailed studies are still required to resolve conflicting or inconclusive outcomes from these investigations before clinical use is warranted.

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“…Since various kinds of literature are available on similar lines, this review mainly discussed the fundamentals of nutraceuticals. It highlighted some essential facts about the therapeutic use of nutraceuticals as complementary medicine to conventional therapies allowing dose reduction and minimizing adverse effects [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Nutraceuticals: An inspiring therapy for lifestyle diseases

Bhardwaj¹,

Kunj²,

Sk³

2023

German J. Pharm. Biomaterials

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Among natural sources, majorly we consider plant-based phytochemicals to offer safe and longlasting effects. Phytochemicals or secondary metabolites are the extract obtained from herbal plants that serve as an excellent venture for their utilization as formulation. Different nutraceuticals (herbal formulations) have always been a part of the world. Everyone around the world could use these supplements for their benefit. Since the end of the eighth century and the beginning of the nineteenth century, the concept of using products has improved. Nutraceutical food supplement plays an essential role for humans to stay healthy and gets all the important nutrients used for the body's basic metabolism and further prevent all kinds of illnesses. The present review highlights the potential of nutraceuticals against various types of leading life-threatening disorders such as diabetes, obesity, asthma, cardiac conditions, arthritis, cancer, etc. This review focuses on the nutraceuticals that help manage certain many life-threatening disorders.

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Development of Topical Nanoemulgel Using Combined Therapy for Treating Psoriasis

Cited by 9 publications

References 25 publications

Design-of-Experiments (DoE)-Assisted Fabrication of Quercetin-Loaded Nanoemulgel and Its Evaluation against Human Skin Cancer Cell Lines

Design-of-Experiments (DoE)-Assisted Fabrication of Quercetin-Loaded Nanoemulgel and Its Evaluation against Human Skin Cancer Cell Lines

Untitled

Nutraceuticals: An inspiring therapy for lifestyle diseases

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