Active development of socio-economic ties and logistic chains with friendly states is of strategic importance due to the current geopolitical situation. Omsk region is located at the crossroads of important railways and waterways. Therefore, it is very important to form a strategy of development of the main directions of deep regional cross-border cooperation. It will allow to steadily develop friendly ties, diversify the economy, use the available resources and innovative technological platforms.The article presents the main approaches to the concept of “cross-border cooperation”. The legislative base is studied, the role and content of interaction of territories on the example of the Omsk region and the Republic of Kazakhstan is revealed. Special attention is paid to the factors influencing successful and constraining cooperation between neighboring regions of the countries. The main directions for the development of socio-economic regional cross-border cooperation are revealed.Aim. The purpose of this article is to analyze the implemented strategy of socio-economic interregional cross-border cooperation, as well as to identify the main points of contact between the Omsk region and the Republic of Kazakhstan.Tasks. During the research, the following tasks were solved: the concept of regional cross-border cooperation was defined; normative-legal acts in this area were analyzed; the strategy of socio-economic regional cross-border cooperation on the example of the Omsk region and the Republic of Kazakhstan was evaluated; the main points of contact in this territory were revealed.Methods. The research is based on scientific publications of scientists in the field of interregional crossborder cooperation. The methods of research, analysis, systematization and generalization were used to assess the effectiveness of the strategy.Results. The results of the evaluation of the strategy of regional cross-border cooperation have shown that in recent years, bilateral socio-economic ties between the Omsk region and the Republic of Kazakhstan are actively developing, many successful investment projects in various areas of the economy are being implemented, forums are regularly held. However, the ongoing changes require constant revision of the strategy of interregional cooperation, as well as the identification of promising areas, taking into account the available resources.Conclusions. The current global situation opens new opportunities for the Omsk region to provide favorable conditions for the sale of goods and technologies, tourism development, etc. There is a high dynamics of long-term partnership, the formation of the legal framework that supports interregional ties between the region and the Republic of Kazakhstan. The article proposes a number of directions for building up the experience of regional mutually beneficial interregional cooperation.