Development of tuberculosis infection control guidelines in a pediatric HIV clinic in sub-Saharan Africa

Carlucci, James G.; Jin, Li; Sanders, Jill; Mohapi, Edith Q.; Mandalakas, Anna M.

doi:10.5588/pha.14.0101

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…In addition, research on epidemiology of non-communicable diseases in people living with HIV [ 41 ], uptake and effectiveness of isoniazid preventive therapy for opportunistic tuberculosis infection [ 42 ], and discordant transmission of HIV in couples [ 20 , 43 , 44 ] had the least number of publications in the same category. Moreover, research on epidemiology of tuberculosis in children [ 45 – 48 ] and impact of HIV on the national health system [ 20 , 49 – 52 ] had a low number of publications in the high-priority research category. However, research on the impact of pregnancy on HIV progression and drug safety during pregnancy had hardly any publications in the low- and non-urgent-priority areas.…”

Section: Resultsmentioning

confidence: 99%

A 30-year bibliometric analysis of research coverage on HIV and AIDS in Lesotho

Mugomeri

Bekele

Mafaesa

et al. 2017

Health Res Policy Sys

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BackgroundGiven the well documented undesired impacts of HIV/AIDS globally, there is a need to create a statistical inventory of research output on HIV/AIDS. This need is particularly important for a country such as Lesotho, whose HIV/AIDS prevalence is one of the highest globally. Research on HIV/AIDS in sub-Saharan Africa continues to trail behind that of other regions, especially those of the developed countries. Lesotho, a sub-Saharan country, is a developing country with lower research output in this area when longitudinally compared to other countries. This study reviewed the volume and scope of the general research output on HIV/AIDS in Lesotho and assessed the coverage of the national research agenda on HIV/AIDS, making recourse to statistical principles.MethodsA bibliometric review of studies on HIV/AIDS retrieved from the SCOPUS and PubMed databases, published within the 30-year period between 1985 and 2016, was conducted. The focus of each of the studies was analysed and the studies were cross-matched with the national research agenda in accordance with bibliometric methodologies.ResultsIn total, 1280 studies comprising 1181 (92.3%) journal articles, 91 (7.1%) books and 8 (0.6%) conference proceedings were retrieved. By proportion, estimation of burden of infection (40.7%) had the highest research volume, while basic (5.5%) and preventive measures (24.4%) and national planning (29.4%) had the lowest. Out of the total studies retrieved, only 516 (40.3%) matched the national research agenda. Research on maternal and child health quality of care, viral load point-of-care devices, and infant point-of-care diagnosis had hardly any publications in the high priority research category of the agenda.ConclusionNotwithstanding a considerable research output on HIV/AIDS for Lesotho, there is insufficient coverage of the national research agenda in this research area. The major research gaps on general research output are in basic and preventive measures as well as national planning. There is also a need to increase targeted funding for HIV/AIDS research to appropriately address the most compelling gaps and national needs.

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Section: Resultsmentioning

confidence: 99%

A 30-year bibliometric analysis of research coverage on HIV and AIDS in Lesotho

Mugomeri

Bekele

Mafaesa

et al. 2017

Health Res Policy Sys

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“…34 A combination of strict infection control measures both at hospital level (no admission without proper infection control) and at the patient's home reduced the cases of MDR and XDR-TB in Tugela Ferry between 2005 and 2015. [34][35][36] South Africa shifted from recruiting hospital nurses and doctors to recruiting mobile team nurses and investing in vehicles to allow systematic home care both preparing the patient's family before discharge and following the patient at home after hospital discharge.…”

Section: Discussionmentioning

confidence: 99%

De-isolation of patients with pulmonary tuberculosis after start of treatment — clear, unequivocal guidelines are missing

Petersen¹,

Khamis

Migliori

et al. 2017

International Journal of Infectious Diseases

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The study review guidelines on isolation of patients with tuberculosis, TB, from the World Health Organization, WHO, Centers for Disease Control and Prevention, CDC, and the European Center for Disease Control, ECDC. The review found that unequivocal guidelines for removing patients out of negative-pressure isolation and de-isolation patients from either single rooms or isolation at home is needed. Studies show that the time of effective treatment is the key parameter to follow to determine if patients are contagious to others or not. This means that standard treatment of multi-drug resistant, MDR, TB will not result in the patient being non-infectious. Thus it is important right from the time of diagnosis to know if the patient is infected with MDR TB or not. Thus the early use of molecular techniques to reveal drug susceptibility is important. Clear guidelines stating if patient with microscopy negative sputum no matter infected with fully susceptible or MDR TB, no matter HIV positive or not is needed.

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WHO strategies for the programmatic management of drug-resistant tuberculosis

Matteelli

Centis

D’Ambrosio

et al. 2016

Expert Review of Respiratory Medicine

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This manuscript presents the evidence on the MDR- /XDR-TB epidemiology and discusses how the five recommended priority actions can be applied at the programmatic level to tackle the epidemic: 1) prevent development of MDR-TB thorough high quality treatment of drug- susceptible TB; 2) expand rapid testing and detection of drug-resistant TB; 3) provide immediate access to effective treatment and proper care; 4) prevent transmission through infection control; 5) increase political commitment and financing. A non-systematic review using Pubmed was carried out in addition to additional relevant information taken from the abstracts of international scientific conferences. Expert commentary: Current and future control of MDR-TB significantly relies on the correct use of new diagnostics and new drugs from one side, and on the consistent application of the five core interventions at the programmatic level. In addition, it is mandatory to tackle the social determinants and socio-economic barriers favouring the MDR-TB, otherwise it will not be possible to reach the planned goals as well as TB Elimination.

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Development of tuberculosis infection control guidelines in a pediatric HIV clinic in sub-Saharan Africa

Cited by 3 publications

References 10 publications

A 30-year bibliometric analysis of research coverage on HIV and AIDS in Lesotho

A 30-year bibliometric analysis of research coverage on HIV and AIDS in Lesotho

De-isolation of patients with pulmonary tuberculosis after start of treatment — clear, unequivocal guidelines are missing

WHO strategies for the programmatic management of drug-resistant tuberculosis

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