Development of Tyrosine Phosphatase 1B Inhibitors Based on Molecular Docking, Kinetics, and Toxicity Studies
Alfredo Téllez‐Valencia,
Irving Hernández‐Ortiz,
Paola Guadalupe López Lujano
et al.
Abstract:Protein Tyrosine Phosphatase 1B (PTP1B) is a protein that contributes to the development of diseases that affect millions of people worldwide. In the last five years, several studies have been carried out to develop a drug that is capable of inhibiting the functions of this protein that are related to chronic degenerative diseases and obesity. In this study, we used PTP1B as a therapeutic target to perform a molecular docking to identify compounds that specifically bind to the PTP1B human protein. After molecu… Show more
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