Development of vascular alterations in mouse thyroids glands

The blood vascular architecture of the rat thyroid gland: A scanning electron microscope study of corrosion casts.

“…IMADA et al (1986b) have further indicated by the same method that in the levothyroxine sodium-treated rat, the follicular capillaries are fine but poor in distribution. These data, together with our present findings and previous experimental studies of other authors (THOMAS, 1945;GORBMAN, 1947;WOLLMAN et al, 1978;RAJ and MESERVE, 1982;KLAK et al, 1983;MESERVE and KLAK, 1984), confirm that the distributions, diameters and arrangements of the follicular capillaries as well as the forms or shapes of the follicular networks are affected by the functional states or conditions of the follicles.…”

“…This finding coincides with those obtained in man, the monkey, dog, cat, rat and other animals by transmission light or electron microscopy of tissue sections, including those of India ink-injected specimens (MAJOR, 1909;WILSON, 1929;MODELL, 1933;BARGMANN, 1939;THOMAS, 1945;GORBMAN, 1947;OGAWA, 1952;HIGAKI et al, 1957;YORISHIMA, 1959 ;WOLLMAN et al, 1978;ERICSON and WOLLMAN, 1980;KLAK et al, 1983). It also confirms that a few to fifty or more follicular capillary networks cluster to form a lobular circulatory unit which is supplied by the lobular artery and vein, and that the parent vessels (interlobular arteries and veins) of the lobular arteries and veins constantly form many collateral circulation routes in the thyroid gland.…”

“…The blood vascular bed of the thyroid gland has been studied in man, the monkey, dog, cat, rat and other animals (MAJOR, 1909;WILSON, 1929;MODELL, 1933;KOCH, 1938;THOMAS, 1945;GORBMAN, 1947;OGAWA, 1952;HIGAKI et al, 1957;YORISHIMA, 1959;WOLLMAN et al, 1978;ERICSON and WOLLMAN, 1980;KLAK et al, 1983). These investigations have been made by trans-mission light or electron microscopy of sectioned tissue samples, including India inkinjected specimens.…”

Three-dimensional imaging of blood vessels in thyroids from normal and levothyroxine sodium-treated rats.

“…All these observations reveal that the structure of blood vessels is reflected by the functional condition of the gland. However, when considering the three-dimensional microvascular architecture of the thyroid gland in the hypofunctional state it is somewhat surprising that no papers have been available except for a short description (KLAK et al, 1983). The present paper was planned to serve towards alleviating this lack of information.…”