Development of vegetable farming: a cause of the emergence of insecticide resistance in populations of Anopheles gambiae in urban areas of Benin

Yadouléton, Anges; Asidi, Alex; Djouaka, Rousseau; James, B.; Agossou, Christian; Akogbéto, Martin

doi:10.1186/1475-2875-8-103

Cited by 151 publications

(152 citation statements)

References 13 publications

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“…The Akron colony from Benin has low level DDT resistance (LT 50 ∼ 1 h) and some kdr mutations, but at lower frequencies than the Ghanaian population [frequency (kdr): Ghanaian M-form 0.58, Akron M-form colony 0.29]. The Akron colony was established in June 2008 at around the same time that Yadouleton et al were assessing DDT susceptibility in the same location (53). In the latter study far higher levels of DDT resistance were observed (15% mortality following a WHO tube assay).…”

Section: Methodsmentioning

confidence: 99%

Identification and validation of a gene causing cross-resistance between insecticide classes inAnopheles gambiaefrom Ghana

Mitchell

Stevenson

Müller

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

228

255

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In the last decade there have been marked reductions in malaria incidence in sub-Saharan Africa. Sustaining these reductions will rely upon insecticides to control the mosquito malaria vectors. We report that in the primary African malaria vector, Anopheles gambiae sensu stricto, a single enzyme, CYP6M2, confers resistance to two classes of insecticide. This is unique evidence in a disease vector of cross-resistance associated with a single metabolic gene that simultaneously reduces the efficacy of two of the four classes of insecticide routinely used for malaria control. The gene-expression profile of a highly DDT-resistant population of A. gambiae s.s. from Ghana was characterized using a unique whole-genome microarray. A number of genes were significantly overexpressed compared with two susceptible West African colonies, including genes from metabolic families previously linked to insecticide resistance. One of the most significantly overexpressed probe groups (false-discovery rate-adjusted P < 0.0001) belonged to the cytochrome P450 gene CYP6M2. This gene is associated with pyrethroid resistance in wild A. gambiae s.s. populations) and can metabolize both type I and type II pyrethroids in recombinant protein assays. Using in vitro assays we show that recombinant CYP6M2 is also capable of metabolizing the organochlorine insecticide DDT in the presence of solubilizing factor sodium cholate.

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Section: Methodsmentioning

confidence: 99%

Identification and validation of a gene causing cross-resistance between insecticide classes inAnopheles gambiaefrom Ghana

Mitchell

Stevenson

Müller

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

228

255

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“…Reporting permethrin resistance rates of 24-82 % in A. gambiae populations from city vegetable farms in Ghana, Yadouleton et al (2009) claimed to have demonstrated that urban agriculture led to resistance development. Unfortunately, resistance was not tested for populations in areas where no urban vegetable production took place, and this lack of control sites and information on background resistance levels mean that it is impossible to ascribe the cause to urban agriculture.…”

Section: Malaria and Urban Agriculturementioning

confidence: 99%

Give peas a chance? Urban agriculture in developing countries. A review

Hamilton

Burry

Mok

et al. 2013

Agron. Sustain. Dev.

165

142

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International audienceUrban agriculture is receiving increasing attention throughout the developing world, but debate rages as to whether it is a blessing or a curse. Some see it as savior for the poor, providing food, and livelihoods, yet to others it is responsible for harboring and vectoring pathogenic diseases and is an archaic practice that has no place along the path toward development. Consequently, the activity receives a mixed reception, and despite much support in many instances, it certainly does not enjoy universal unimpeded progress. Here, we undertake a global tour of urban agriculture throughout the developing world in an attempt to elucidate the various benefits, costs, and hindrances associated with the practice. Through this analysis we identify the need for better understanding of the following six aspects if urban agriculture is to make a meaningful contribution to food security and sustenance of livelihoods in the future: (1) the global and regional extent of urban agriculture; (2) the contribution of urban agriculture to communicable diseases, especially malaria but also diarrheal disease; (3) the role that urban agriculture does and/or could play in abating both malnutrition and obesity; (4) the impacts of urban agriculture on women; (5) appropriate methods of achieving governance and institutional support; and (6) the risks posed by chemical pollutants, particularly as Africa becomes increasingly industrialized. Overlaying these, we suggest that the time is ripe to extend the debate about urban agriculture’s positive and negative environmental impacts—especially in relation to carbon emissions—from primarily a developed world concern to the developing world, particularly since it is the developing world where population growth and consequent resource use is increasing most rapidly

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“…This is due to their relatively low mammalian toxicity and rapid knockdown effect that cause paralysis of an insect. Pyrethroids are also used in agriculture to control crop pests and this intensive use has led to reports of reduced efficacy [5] [6].…”

Section: Introductionmentioning

confidence: 99%

A Review of Agricultural Pesticides Use and the Selection for Resistance to Insecticides in Malaria Vectors

Philbert¹,

Lyantagaye²,

Nkwengulila³

2014

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Most national malaria control programmes rely extensively on pyrethroid insecticides to control mosquito vectors of this disease. Unfortunately, the intensive use of this class of insecticides both in public health and agriculture has led to its reduced efficacy. The objective of this review was to assess the role of agricultural pesticides use on the development of resistance to insecticides in malaria vectors and the potential impact of this resistance on control activities. We searched library catalogues and public databases for studies that included data on resistance to the major classes of insecticides: organochlorines, carbamates, organophosphates and pyrethroids, in the malaria vectors of Anopheles genera. There is a strong geographical bias in published studies many originating from West African countries. Several studies demonstrate that resistance to pyrethroids is widespread in the major malaria vectors of the Anopheles gambiae and Anopheles funestus complexes. Assessing the impact of insecticide resistance on vector control is complicated owing to the lack of studies into the epidemiological consequences of resistance on the control of malaria and other vector borne diseases.

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Development of vegetable farming: a cause of the emergence of insecticide resistance in populations of Anopheles gambiae in urban areas of Benin

Cited by 151 publications

References 13 publications

Identification and validation of a gene causing cross-resistance between insecticide classes inAnopheles gambiaefrom Ghana

Identification and validation of a gene causing cross-resistance between insecticide classes inAnopheles gambiaefrom Ghana

Give peas a chance? Urban agriculture in developing countries. A review

A Review of Agricultural Pesticides Use and the Selection for Resistance to Insecticides in Malaria Vectors

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