2013
DOI: 10.1159/000346773
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Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures

Abstract: Virus-like particle (VLP) technology is a promising approach for the construction of novel vaccines, diagnostic tools, and gene therapy vectors. Initially, VLPs were primarily derived from non-enveloped icosahedral or helical viruses and proved to be viable vaccine candidates due to their effective presentation of epitopes in a native conformation. VLP technology has also been used to prepare chimeric VLPs decorated with genetically fused or chemically coupled epitope stretches selected from immunologically de… Show more

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Cited by 4,405 publications
(130 citation statements)
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“…Therefore, despite the high level of pre-existing NoV antibodies [43,44], the use of NoV VLPs as a carrier might not be impaired by them. Applications for these engineered VLPs include the creation of novel vaccines presenting unique immunological content on their surface; steering or enhancing the immune response; targeting specific cells; and encapsidation or display of different molecules, from nucleotides, genes, peptides and proteins to therapeutic drugs and inorganic nanomaterials [13,45].…”
Section: Resultsmentioning
confidence: 99%
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“…Therefore, despite the high level of pre-existing NoV antibodies [43,44], the use of NoV VLPs as a carrier might not be impaired by them. Applications for these engineered VLPs include the creation of novel vaccines presenting unique immunological content on their surface; steering or enhancing the immune response; targeting specific cells; and encapsidation or display of different molecules, from nucleotides, genes, peptides and proteins to therapeutic drugs and inorganic nanomaterials [13,45].…”
Section: Resultsmentioning
confidence: 99%
“…In addition, there is an increasing number of reports in which chimeric VLPs from different viral origins were prepared by either genetic fusion or chemical coupling of epitope peptides or other molecules to the inner or outer surfaces of the VLPs (reviewed, for example, in [13]). However, in all of these cases, the display was achieved by genetic fusion of the protein fragment and the VLP sequence or by covalent chemical linkage to the reactive residues of the VLP surface.…”
Section: Introductionmentioning
confidence: 99%
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“…VLPs do not contain viral genetic material and represent high-density displays of viral structural proteins that efficiently trigger key parts of the immune system for B cell and/or T cell responses (1)(2)(3). VLPs composed of the small envelope proteins (HBsAgS) derived from hepatitis B virus (HBV) are the antigenic components of a successful protective vaccine (4,5).…”
mentioning
confidence: 99%
“…When viral surface proteins are expressed in a eukaryotic host with no other viral gene products present, many of them have the intrinsic capacity to self-assemble into VLPs [29,30]. VLPs are an excellent tool for developing diagnostics and vaccines.…”
Section: Discussionmentioning
confidence: 99%