Abstract:Background In many endemic areas, Plasmodium vivax malaria is predominantly a disease of young adults and children. International recommendations for radical cure recommend fixed target doses of 0.25 or 0.5 mg/kg/day of primaquine for 14 days in glucose-6-phosphate dehydrogenase normal patients. As for many antimalarial drugs there is evidence that children have lower exposures than adults for the same weight adjusted dose. We, therefore, aimed to develop 14-day weight-based and age-based primaquine regimens a… Show more
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