1977
DOI: 10.1038/268455a0
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Development of β-adrenergic receptor subsensitivity by antidepressants

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Cited by 721 publications
(119 citation statements)
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“…We also observed the previously described (Banerjee et al, 1977) down-regulation of betaadrenergic receptors after chronic administration ofDMI. As expected on the basis of our results with thyroid hormone administration alone, we found that concurrent administration of only large doses of thyroid hormones had a significant antagonistic effect on the down-regulation produced by the drug.…”
Section: Discussionsupporting
confidence: 79%
“…We also observed the previously described (Banerjee et al, 1977) down-regulation of betaadrenergic receptors after chronic administration ofDMI. As expected on the basis of our results with thyroid hormone administration alone, we found that concurrent administration of only large doses of thyroid hormones had a significant antagonistic effect on the down-regulation produced by the drug.…”
Section: Discussionsupporting
confidence: 79%
“…The beta-1 adrenergic receptor is well known to show altered density and/or sensitivity in depression and is downregulated in several brain regions after long-term treatment with certain antidepressants (Ordway et al, 1988;Manji and Lenox, 2000;Banerjee et al, 1977). A recent clinical study found a tendency for a relationship between an adrb1 polymorphism and a better and more rapid response to antidepressant treatment (Zill et al, 2003).…”
Section: Discussionmentioning
confidence: 99%
“…12,16,17 We have found that those antidepressants that cause this effect do so most robustly in certain amygdaloidal nuclei, such as its basolateral nucleus. 18 Moreover, down-regulation of ␤ 1 adrenoceptors is only produced by drugs that acutely enhance noradrenergic function; SSRIs, for example, do not produce this effect ( Figure 2).…”
Section: Delayed Pharmacological Effects Of Antidepressantsmentioning
confidence: 99%