Development, optimization and biological evaluation of chitosan scaffold formulations of new xanthine derivatives for treatment of type-2 diabetes mellitus

Lupașcu, Florentina; Dash, Mamoni; Samal, Sangram Keshari; Dubruel, Peter; Lupușoru, Cătălina Elena; Lupusoru, Raoul-Vasile; Dragostin, Oana Maria; Profire, Lenuța

doi:10.1016/j.ejps.2015.06.008

Cited by 28 publications

(27 citation statements)

References 47 publications

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“…This free radical is reduced in the presence of an antioxidant molecule, changing the yellow color with reduced DPPH. [24,25] The scavenging activity of the GG and DC/GG sponges were found as 51.8 ± 3.92 and 64.5 ± 4.71%, respectively (shown in Figure 2). Based on these results, it can be concluded that DC/GG sponge was 1.25 times more active than GG sponge, which can be ascribed to the impregnated DC.…”

Section: Antioxidant Abilitymentioning

confidence: 96%

Inflammatory response study of gellan gum impregnated duck’s feet derived collagen sponges

Song

Lee

Cha

et al. 2016

Journal of Biomaterials Science, Polymer Edition

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Tissue engineered biomaterials have biodegradable and biocompatible properties. In this study, we have fabricated sponges using duck's feet derived collagen (DC) and gellan gum (GG), and further studied its inflammatory responses. The as-prepared duck's feet DC/GG sponges showed the possibility of application as a tissue engineering material through in vitro and in vivo experiments. The physical and chemical properties of sponges were characterized by compression strength, porosity, and scanning electron microscopy, etc. In vitro cell viability were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay. An inflammatory response was studied after seeding RAW264.7 cells on as-fabricated sponges using reverse transcriptase-polymerase chain reaction. In vivo studies were carried out by implanting in subcutaneous nude mouse followed by extraction, histological staining. Collectively, superior results were showed by DC/GG sponges than GG sponge in terms of physical property and cell proliferation and thus can be considered as a potential candidate for future tissue engineering applications.

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Section: Antioxidant Abilitymentioning

confidence: 96%

Inflammatory response study of gellan gum impregnated duck’s feet derived collagen sponges

Song

Lee

Cha

et al. 2016

Journal of Biomaterials Science, Polymer Edition

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“…Dash, Chiellini, Ottenbrite, & Chiellini, 2011;Mamoni Dash, Piras, & Chiellini, 2009). This natural cationic polymer, offers unique properties; it is biologically renewable, biodegradable, biocompatible, nonantigenic, non-toxic, and biofunctional (Lupascu et al, 2015). Chitosan has been proven to accelerate wound healing, stimulate the macrophage activity, and inhibit the growth of tumor cells and posses antimicrobial properties (R. Muzzarelli et al, 1990;R.…”

Section: Introductionmentioning

confidence: 99%

Ulvan-chitosan polyelectrolyte complexes as matrices for enzyme induced biomimetic mineralization

Dash

Samal

Morelli

et al. 2018

Carbohydrate Polymers

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Polyelectrolyte complexes (PEC) of chitosan and ulvan were fabricated to study ALP mediated formation of apatitic minerals. Scaffolds of the PEC were subjected to alkaline phosphatase (ALP) and successful mineral formation was studied using SEM, Raman and XRD techniques. Investigation of the morphology via SEM shows globular structures of the deposited minerals, which promoted cell attachment, proliferation and extracellular matrix formation. The PEC and their successful calcium phosphate based mineralization offers a greener route of scaffold fabrication towards developing resorbable materials for tissue engineering.

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“…The sodium salt of theophylline (1,3‐dimethyl‐xanthine) 102 was esterified with ethyl cloroacetate 103 to give (1,3‐dimethylxanthin‐7‐yl) ethyl acetate 104 , which was turned into hydrazide derivative 105 via reacting with hydrazine hydrate. Heterocyclization of thiosemicarbazides 106a , b with chloracetyl chloride 107 gave the corresponding thiazolidin‐4‐one derivatives 108a , b (Scheme ).…”

Section: From Thiosemicarbazidesmentioning

confidence: 99%

Thiazolidine‐4‐ones from Thiocarbohydrazides

Hassan

Makhlouf

2018

Journal of Heterocyclic Chem

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in Wiley Online Library (wileyonlinelibrary.com).Several methods for the preparation of thiazolidin-4-ones from thiocarbohydrazides over the last 15 years are highlighted. Thiosemicarbazides, thiocarbohydrazides, thioamides, and hydrazinecarbothioamides as well as thioureas were used to obtain different substituted thiazolidinones under reaction conditions. Thiazolidinones can be synthesized either by a one-pot three-component condensation or a two-step process. Also, the mechanism of formation, regioselectivity issues, and biological activities of different thiazolidinones were discussed.

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Development, optimization and biological evaluation of chitosan scaffold formulations of new xanthine derivatives for treatment of type-2 diabetes mellitus

Cited by 28 publications

References 47 publications

Inflammatory response study of gellan gum impregnated duck’s feet derived collagen sponges

Inflammatory response study of gellan gum impregnated duck’s feet derived collagen sponges

Ulvan-chitosan polyelectrolyte complexes as matrices for enzyme induced biomimetic mineralization

Thiazolidine‐4‐ones from Thiocarbohydrazides

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