Development process and clinical application of collagenase chemonucleolysis in the treatment of lumbar disc herniation: a narrative review in China

Abstract

Lumbar disc herniation (LDH) is one of the most common causes of lumbocrural pain. In the past 20 years, the incidence of LDH has increased dramatically. There are many treatments for LDH, including conservative treatment (such as acupuncture and physiotherapy), minimally invasive interventional treatment (such as collagenase chemonucleolysis and radiofrequency ablation) and surgical treatment. The main purpose of this paper is to review the development process and application status of collagenase chemonucleolysis in the treatment of LDH at home and abroad and provide a reference for clinical treatment.

Safety and efficacy of Yaobitong capsules for lumbar disc herniation: A multicenter, randomized, double-blinded, parallel, positive-controlled clinical trial

“…4 In China, relevant epidemiological investigations show that LDH incidence is as high as 14.3%, and with changes in lifestyle and the aging population, LDH incidence has increased significantly, particularly in younger persons. 5 The most common LDH treatment options are surgical options and conservative treatments. 6 Only 10% of LDH cases are candidates for immediate surgery, and 8-40% of patients still feel pain after surgery.…”

Effect of Collagenase Chemonucleolysis on Residual Pain After Transforaminal Lumbar Endoscopic Discectomy

“…Meanwhile, proteoglycan is cracked and degraded into proline, hydroxyproline and other small molecular amino acids, which are finally absorbed by the human body. 11 The reduction or disappearance of the protrusion can relieve or eliminate the compression of the protrusion on nerve tissues. In addition, collagenase can also inhibit the activity of phospholipase A2 (PLA2), which is an inflammatory substance in nerve roots, reduce or eliminate the inflammatory reaction in nerve roots, and ultimately improve the clinical signs and symptoms of patients.…”