Development stages of anaplastic liver cancer in the experiment at rats

Abstract

Development stages of anaplastic liver cancer were investigated in the experiment at rats. Carcinogen (DMBA) diluted in the solution of medical bile, used as cocancirogen, injected intrahepatically. Histologic discomplexation signs of stringer structures in the liver lobules were revealed after 30 days from the beginning of experiment, mostly, subcapsular zones, hyperplasia of hepatocytes with enlargement nuclear‐cytoplazmatic correlation. Formation trabecular and tubular structures from large hepatocytes with large hyperchomic nuclears and signs of hepatocytes' dysplasia of different expressed degree was marked on 60 day of the experiment. Singular massy hepatocytes proliferation with signs of cells' atipism was revealed after 90 days from the beginning of experiment. Trabecular and tubular structures from hepatic cells in the condition of severe dysplasia are remained among massy foci. Morphologic picture of anaplastic cancer is observed after 120 days in the liver of rats.Research results confirm hepatocellular origin of anaplastic liver cancer.Development stages of anaplastic liver cancer of rats are following: progressing dysplasia of hepatocytes; formation of atypical trabecular and tubular structures from large hepatocytes, discomplexation of tubular and trabecular structures with hepatocytes' anaplasia.