Development trends of human organoid‐based COVID‐19 research based on bibliometric analysis

Abstract

Coronavirus disease 2019 (COVID‐19), a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has posed a catastrophic threat to human health worldwide. Human stem cell‐derived organoids serve as a promising platform for exploring SARS‐CoV‐2 infection. Several review articles have summarized the application of human organoids in COVID‐19, but the research status and development trend of this field have seldom been systematically and comprehensively studied. In this review, we use bibliometric analysis method to identify the characteristics of organoid‐based COVID‐19 research. First, an annual trend of publications and citations, the most contributing countries or regions and organizations, co‐citation analysis of references and sources and research hotspots are determined. Next, systematical summaries of organoid applications in investigating the pathology of SARS‐CoV‐2 infection, vaccine development and drug discovery, are provided. Lastly, the current challenges and future considerations of this field are discussed. The present study will provide an objective angle to identify the current trend and give novel insights for directing the future development of human organoid applications in SARS‐CoV‐2 infection.

Mapping knowledge landscapes and emerging trends of Marburg virus: A text-mining study

“…Especially during the global pandemic of COVID-19, the number of relevant studies has increased rapidly. Many scholars have utilized the bibliometric method to aid in comprehending the prevalence of COVID-19 and the evolution of treatment and prevention approaches, especially vaccines [ [21] , [22] , [23] , [24] , [25] , [26] ]. Moreover, the application of bibliometric analysis could also facilitate an evaluation of scientific influence and research quality within specific domains and direct scientists and policymakers in establishing priority research areas while providing decision-making support for infectious disease prevention and control strategies [ [18] , [19] , [20] ].…”

“…For instance, in the field of infectious diseases, the global COVID-19 pandemic triggered by the novel coronavirus in 2019 became a pivotal research subject in the biomedical domain. A substantial amount of bibliometric analysis has summarized various aspects of COVID-19, including its pathogenesis, vaccine development, and prognosis [ [21] , [22] , [23] , [24] , [25] , [26] ]. However, we note the scarcity of scholarly literature conducting bibliometric analyses in the domains of the Marburg virus or Ebola virus [ 27 , 28 ].…”

Bibliometric analysis of global research on human organoids

“…In recent years, there has been a gradual emergence of bibliometric studies related to organoids [ [42] , [43] , [44] , [45] , [46] , [47] ]. Compared to this study, these studies have a more concentrated focus.…”

Unveiling global research trends and hotspots on mitochondria in NAFLD from 2000 to 2023: A bibliometric analysis

“…This approach provides detailed information on authors, keywords, journals, countries, institutions, and references within the relevant research area 11 . Various bibliometric tools have gained popularity in the medical field, particularly in disciplines like oncology, respiratory and infection 12–14 . These tools, including CiteSpace, VoSviewer, and the R package “bibliometrix,” offer valuable visualization capabilities to aid in literature analyses 14–16 .…”

“… 11 Various bibliometric tools have gained popularity in the medical field, particularly in disciplines like oncology, respiratory and infection. 12 , 13 , 14 These tools, including CiteSpace, VoSviewer, and the R package “bibliometrix,” offer valuable visualization capabilities to aid in literature analyses. 14 , 15 , 16 Researchers have extensively utilized these resources to effectively present and interpret their findings.…”