Developmental and neurochemical features of cholinergic neurons in the murine cerebral cortex

Consonni, Silvia; Leone, Silvia; Becchetti, Andrea; Amadeo, Alida

doi:10.1186/1471-2202-10-18

Cited by 36 publications

(35 citation statements)

References 46 publications

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“…The cortex of the Goettingen miniature pig displayed numerous ChAT-ir fibers similar to other mammals (e.g., humans, Mufson et al, 1989; Mesulam et al, 1992; nonhuman primates, Mrzljak and Goldman-Rakic, 1993; Mesulam, 2004; Raghanti et al, 2008; rodents, Ichikawa and Hirata, 1986; Lysakowski et al, 1986; Mechawar et al, 2000). Small ChAT positive neurons were seen within the cingulate, insular and piriform cortices as described in some rodent species (Eckenstein and Baughman, 1984; Mufson and Cunningham, 1988; Mechawar et al, 2000; Bhagwandin et al, 2006; Consonni et al, 2009) including murid rodents (Kruger et al, 2012) and the Hottentot golden mole (Calvey et al, 2013), but not in the BALB/c ByJ mouse (Kitt et al, 1994), guinea pig (Maley et al, 1988), monotremes (Manger et al, 2002) and most nonhuman primates (Mesulam et al, 1984; Everitt et al, 1988; Kordower et al, 1989). ChAT positive neurons in supragranular cortical layers (II–IV) have been reported in some rodent species (Eckenstein and Baughman, 1984; Mufson and Cunningham, 1988; Mechawar et al, 2000; Bhagwandin et al, 2006; Consonni et al, 2009), rabbit (Varga et al, 2003), feline (Avendaño et al., 1996), fetal Macaca mulatta (Hendry et al, 1987) and to a lesser degree in humans (Kasashima et al, 1999).…”

Section: Discussionmentioning

confidence: 81%

Cholinergic profiles in the Goettingen miniature pig (Sus scrofa domesticus) brain

Mahady

Perez

Emerich

et al. 2016

J of Comparative Neurology

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Central cholinergic structures within the brain of the even-toed hoofed Goettingen miniature domestic pig (Sus scrofa domesticus) were evaluated by immunohistochemical visualization of choline acetyltransferase (ChAT) and the low-affinity neurotrophin receptor, p75NTR. ChAT immunoreactive (-ir) perikarya were seen in the olfactory tubercle, striatum, medial septal nucleus, vertical and horizontal limbs of the diagonal band of Broca and the nucleus basalis of Meynert, medial habenular nucleus, zona incerta, neurosecretory arcuate nucleus, cranial motor nuclei III and IV, Edinger-Westphal nucleus, parabigeminal nucleus, pedunculopontine nucleus and laterodorsal tegmental nucleus. Cholinergic ChAT-ir neurons were also found within transitional cortical areas (insular, cingulate, and piriform cortices) and hippocampus proper. ChAT-ir fibers were seen throughout the dentate gyrus and hippocampus, in the mediodorsal, laterodorsal, anteroventral and parateanial thalamic nuclei, the fasciculus retroflexus of Meynert, basolateral and basomedial amygdaloid nuclei, anterior pretectal and interpeduncular nuclei, as well as select laminae of the superior colliculus. Double immunofluorescence demonstrated that virtually all ChAT-ir basal forebrain neurons were also p75NTR positive. The present findings indicate that the central cholinergic system in the miniature pig is similar to other mammalian species. Therefore, the miniature pig may be an appropriate animal model for preclinical studies of neurodegenerative diseases where the cholinergic system is compromised.

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Section: Discussionmentioning

confidence: 81%

Cholinergic profiles in the Goettingen miniature pig (Sus scrofa domesticus) brain

Mahady

Perez

Emerich

et al. 2016

J of Comparative Neurology

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“…With the exception of the lizard Gallotia (Medina et al 1993), no ChAT-ir cells have been found in the cortex of birds and reptiles Brauth et al 1985;Hoogland and Vermeulen-Van der Zee 1990;Powers and Reiner 1993;Medina and Reiner 1994). In mammals, cholinergic cells have been detected in the cortex of rats (Houser et al 1983;Ichikawa and Hirata 1986;Parnavelas et al 1986;Ichikawa et al 1997) and mice (Mufson and Cunningham 1988;Consonni et al 2009) but not dogs, cats, guinea pigs, other rodents, monotremes (Kimura et al 1981;Vincent and Reiner 1987;Maley et al 1988;St-Jacques et al 1996;Manger et al 2002;Bhagwandin et al 2006) or adult primates including humans Satoh and Fibiger 1985;Mesulam and Geula 1988;Geula et al 1993;Alonso and Amaral 1995). Therefore, the presence of cholinergic cells in the pallium/cortex of vertebrates is is most likely not a primitive feature for vertebrates.…”

Section: Localization Of Chat-ir Elements In the Forebrain Of Lungfismentioning

confidence: 93%

Organization of the cholinergic systems in the brain of two lungfishes, Protopterus dolloi and Neoceratodus forsteri

et al. 2011

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Lungfishes (dipnoans) are currently considered the closest living relatives of tetrapods. The organization of the cholinergic systems in the brain has been carefully analyzed in most vertebrate groups, and major shared characteristics have been described, although traits particular to each vertebrate class have also been found. In the present study, we provide the first detailed information on the distribution of cholinergic cell bodies and fibers in the central nervous system in two representative species of lungfishes, the African lungfish (Protopterus dolloi) and the Australian lungfish (Neoceratodus forsteri), as revealed by immunohistochemistry against the enzyme choline acetyltransferase (ChAT). Distinct groups of ChAT immunoreactive (ChAT-ir) cells were observed in the basal telencephalon, habenula, isthmic nucleus, laterodorsal tegmental nucleus, cranial nerve motor nuclei, and the motor column of the spinal cord, and these groups seem to be highly conserved among vertebrates. In lungfishes, the presence of a cholinergic cell group in the thalamus and the absence of ChAT-ir cells in the tectum are variable traits, unique to this group and appearing several times during evolution. Other characters were observed exclusively in Neoceratodus, such as the presence of cholinergic cells in the suprachiasmatic nucleus, the pretectal region and the superior raphe nucleus. Cholinergic fibers were found in the medial pallium, basal telencephalon, thalamus and prethalamus, optic tectum and interpeduncular nucleus. Comparison of these results with those from other classes of vertebrates, including a segmental analysis to correlate cell populations, reveals that the cholinergic systems in lungfishes largely resemble those of amphibians and other tetrapods.

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“…Studies of birds and reptiles have revealed the lack of cholinergic cells in cortical regions Brauth et al, 1985;Hoogland and Vermeulen-Van der Zee, 1990;Powers and Reiner, 1993;Medina and Reiner, 1994], with the lone exception of the lizard Gallotia gallotia [Medina et al, 1993]. In mammals, cholinergic cells were detected in the cortex of rats [Houser et al, 1985;Ichikawa and Hirata, 1986;Parnavelas et al, 1986;Ichikawa et al, 1997] and mice [Mufson and Cunningham, 1988;Consonni et al, 2009] but not in dogs, cats, guinea pigs, some rodents, monotremes [Kimura et al, 1981;Vincent and Reiner, 1987;Maley et al, 1988;St-Jacques et al, 1996;Manger et al, 2002;Bhagwandin et al, 2006] and adult primates, including humans Satoh and Fibiger, 1985;Mesulam and Geula, 1988;Geula et al, 1993;Alonso and Amaral, 1995]. Therefore, the presence of cholinergic cells in the pallium/cortex of vertebrates seems to be a variable feature that appears several times in evolution.…”

Section: Localization Of Chat-ir Elements In the Forebrain Of Holosteansmentioning

confidence: 99%

Comparative Analysis of the Organization of the Cholinergic System in the Brains of Two Holostean Fishes, the Florida Gar Lepisosteus platyrhincus and the Bowfin Amia calva

Morona¹,

López²,

Northcutt³

et al. 2013

Brain Behav Evol

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The cholinergic system in the brain has been widely studied in most vertebrate groups, but there is no information available about this neurotransmission system in the brains of holostean fishes, a primitive and poorly understood group of actinopterygian fishes. The present study provides the first detailed information on the distribution of cholinergic cell bodies and fibers in the central nervous system in two holostean species, the Florida gar, Lepisosteus platyrhincus, and the bowfin, Amia calva. Immmunohistochemistry against the enzyme choline acetyltransferase (ChAT) revealed distinct groups of ChAT-immunoreactive (ChAT-ir) cells in the habenula, isthmic nucleus, laterodorsal tegmental nucleus, octavolateral area, reticular formation, cranial nerve motor nuclei and the motor column of the spinal cord, all of which seem to be highly conserved among vertebrates. Some ChAT-ir cells were detected in the basal telencephalon that appear in actinopterygians for the first time in the evolution of this neurotransmission system, whereas the remarkable cholinergic population in the optic tectum is a peculiar characteristic, the presence of which varies throughout evolution, although it is present in all teleosts studied. Abundant cholinergic fibers were found in the pretectal region and optic tectum, where they probably modulate vision, and in the hypothalamus and the interpeduncular neuropil. Some interspecific differences were also observed, such as the presence of ChAT-ir cells in the supraoptoparaventricular band only in Lepisosteus and in in the nucleus subglomerulosus only in Amia. In addition, ChAT-ir fibers in the olfactory bulb were detected only in Amia. Comparison of these results with those from other classes of vertebrates, and a segmental analysis to correlate cell populations, reveal that the pattern of the cholinergic system in holosteans is very close to that in ancestral actinopterygian fishes, as recently described in the bichir (Cladistia), although an important evolutionary novelty in holosteans is the presence of cholinergic cells in the basal telencephalon.

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Developmental and neurochemical features of cholinergic neurons in the murine cerebral cortex

Cited by 36 publications

References 46 publications

Cholinergic profiles in the Goettingen miniature pig (Sus scrofa domesticus) brain

Cholinergic profiles in the Goettingen miniature pig (Sus scrofa domesticus) brain

Organization of the cholinergic systems in the brain of two lungfishes, Protopterus dolloi and Neoceratodus forsteri

Comparative Analysis of the Organization of the Cholinergic System in the Brains of Two Holostean Fishes, the Florida Gar <b><i>Lepisosteus platyrhincus</i></b> and the Bowfin <b><i>Amia calva</i></b>

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