1995
DOI: 10.1523/jneurosci.15-10-06797.1995
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Developmental and regional expression of multifunctional Ca2+/calmodulin-dependent protein kinase isoforms in rat brain

Abstract: Multifunctional Ca2+/calmodulin-dependent protein kinase (CaM kinase) participates in diverse calcium signaling pathways in neurons. The alpha- and beta-CaM kinase isoforms are neuron-specific and highly abundant in rat brain. The variable domain of CaM kinase is a potential site for the generation of isoform diversity by alternative spicing of its N- and/or C-terminal segments. We used specific PCR primers which span the variable domain of either alpha- or beta-CaM kinase and isolated three new isoforms from … Show more

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Cited by 157 publications
(176 citation statements)
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“…Splice variants of the ␣ and the ␦ gene (␣ B -and ␦ B -CaMKII) contain a nuclear localization signal (NLS) that directs each of these to the nucleus (Srinivasan et al, 1994;Brocke et al, 1995). Not surprisingly, CaMKII-mediated changes in gene expression require nuclear localization (Ramirez et al, 1997).…”
Section: Nuclear Targetingmentioning
confidence: 99%
See 1 more Smart Citation
“…Splice variants of the ␣ and the ␦ gene (␣ B -and ␦ B -CaMKII) contain a nuclear localization signal (NLS) that directs each of these to the nucleus (Srinivasan et al, 1994;Brocke et al, 1995). Not surprisingly, CaMKII-mediated changes in gene expression require nuclear localization (Ramirez et al, 1997).…”
Section: Nuclear Targetingmentioning
confidence: 99%
“…A transcription factor, NeuroD, that regulates dendritic growth and morphology has been found recently to be phosphorylated by CaMKII in granule cells, but it is not known which kinase isoform is involved (Gaudilliere et al, 2004). ␣ B -CaMKII is abundant in brain but essentially restricted to the midbrain and diencephalon, regions that have approximately equal amounts of ␣-and ␣ BCaMKII (Walaas et al, 1983;Brocke et al, 1995). Holoenzymes with primarily nuclear subunits are found almost exclusively in the nucleus and vice versa, whereas both nuclear and cytosolic localization is seen at equal expression of the two isoforms (Srinivasan et al, 1994).…”
Section: Nuclear Targetingmentioning
confidence: 99%
“…4,5 Alternative splicing of the primary transcripts encoded by 4 genes (␣, ␤, ␥, and ␦) results in the generation of different CaMKII variants. 6,7 Members of the ␣-and ␤-classes are expressed mainly in neuronal tissue, whereas ␥-and ␦-CaMKII isoforms are abundantly expressed in all tissues. 6,8,9 Multifunctionality of the homomultimeric or heteromultimeric holoenzyme composed of 8 through 12 subunits 10 seems to counteract its specific cellular functions.…”
Section: T He Camentioning
confidence: 99%
“…Despite its proposed ability to bind F-actin, some CaMKII␤ in some cells appeared cytosolic. This may be because this protein occurs in at least four splice forms (32), and some of the splicing occurs in the suggested actin-binding region (31). In summary, IP3kinA was usually found to be co-localized with CaMKII, its endogenous activator, and this co-localization occurred more often with the ␤ than the ␣ isoform.…”
Section: Determination Of An Actin Association Region In Ip3kina-mentioning
confidence: 99%