Developmental challenges in HIV infected children—An updated systematic review

Sherr, Lorraine; Croome, Natasha; Castaneda, Katherine Parra; Bradshaw, Katie; Romero, Rocio Herrero

doi:10.1016/j.childyouth.2014.03.040

Cited by 71 publications

(74 citation statements)

References 34 publications

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“…9 In contrast a quality of life study conducted among Indian children revealed that they have a better psychosocial and school functioning scores than children with cystic fibrosis 5 HIV children with normal CD4 count and undetectable viral load had school (51%) and dropout (28.6%), 10 they have compromised executive function and information processing, 11 81% systematic review reported some form of cognitive delay. 12 Children aged between 9-16 years in a study reported two third of the youth had met the criteria for at least one psychiatric disorder based on their youth versions of diagnostic interview schedule for children (DISC -IV). The predisposing factors for the development of psychiatric illness identified were biological, psychological and social factors for the development of depression anxiety disruptive disorders and hyperactive disorders.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Spirulina Supplement and Selected Yogasanas on Quality of Life of Children With Hiv Infection

Prabhavathi¹,

Nalini²,

Sethu³

2016

Int. J. Res. Ayurveda Pharm.

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The present study was aimed to evaluate the effectiveness of spirulina supplement and selected yogasanas on quality of life of children with HIV infection. Two hundred children with HIV infection aged between 5 and 18 years belong to both sexes participated in the study hundred children were chosen for both experimental and control groups. Commercially available and ISO certified spirulina food supplement was used in the study. Selected yogasnas such as tadasana (standing pose), trikonasana (triangle pose), padmasana (lotus pose), vajrasana, yogamudra and shavasana (corpse pose) were practiced by the participants under supervision of experts. The domains of quality of life scores also showed a significant change in all comparisons of pretest and posttests of experimental group with the control group and between the experimental and control group of both parent reported scores and self reported scores except the self reported psychosocial summary scores in post test II. The interventions that the spirulina supplement and selected yogasanas would have had a significant impact on the physiological parameters and the quality of life of children with HIV infection/AIDS.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Spirulina Supplement and Selected Yogasanas on Quality of Life of Children With Hiv Infection

Prabhavathi¹,

Nalini²,

Sethu³

2016

Int. J. Res. Ayurveda Pharm.

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“…A recent meta-analysis found that working memory, executive functioning, and processing speed are the cognitive domains most affected in children and adolescents living with HIV [8]. Sherr et al suggested that since the evidence for HIV-associated cognitive impairment is consistent, children living with HIV should be routinely and regularly monitored for developmental delays and cognitive dysfunction so they can be referred to available intervention [9]. Without access to rehabilitative services, children who experience developmental delays of disabilities struggle to achieve school readiness.…”

Section: Introductionmentioning

confidence: 99%

A study protocol “saving futures: developing an integrated model of rehabilitation and paediatric HIV care to foster success at school”

Chetty

Maddocks

Cobbing

et al. 2018

Pilot Feasibility Stud

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BackgroundA significant number of children experience disabilities as a result of living with HIV, including those on antiretroviral therapy (ART). Current paediatric HIV care does not prioritise rehabilitation. Furthermore, little attention is paid to cognitive development and educational needs, thereby placing the future of these children at risk. This can be mitigated by providing rehabilitation services to help overcome these disabilities.MethodsThe study will assess the feasibility (acceptability, practicality, preliminary efficacy) of an integrated model of rehabilitation and paediatric HIV care in order to improve diagnosis and interventions for disability amongst children living with HIV between the ages of 5 and 10 years. The model will integrate data entry and management tools, improving identification, referral, and linkage to care, with an intervention approach that can be used by trained lay health professionals. The study targets both physical and cognitive impairments that lead to disabilities to improve school readiness and success. Phase 1 will inform the design of an optimal integrated model of rehabilitation and paediatric HIV care in a public healthcare setting in South Africa. The study will first undertake a formative investigation of the factors impacting integration of rehabilitation with paediatric HIV care from the perspective of caregivers and health professionals. It will use qualitative methods, including in-depth interviews and focus group discussions. The knowledge from this phase will inform the design of the model in phase 2, and phase 3 will pilot the integrated rehabilitation and paediatric HIV model with the aim to improve school readiness for the participants at the study site. The pilot intervention will be formally evaluated.DiscussionThe results from this study will determine whether the model has potential for widespread application in South African paediatric HIV care and recommend further possible modifications. This will inform the development of a proposal to support the current government initiative to strengthen disability and rehabilitation services. The study results will also inform South Africa’s current efforts to strengthen early interventions for children with disabilities and will be an important and critically needed step in the use of rehabilitation to strengthen paediatric HIV care in the region.

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“…Youth with perinatally-acquired HIV (PHIV) may show cognitive deficits as well as developmental delay even among those with reconstituted immunologic and virologic status, (Cohen et al, 2014; Crowell et al, 2014; Ene et al, 2014; Koekkoek et al, 2008; Linn et al, 2015; Malee et al, 2016; Martin et al, 2006; Nichols et al, 2016; Nozyce et al, 2006; Redmond et al, 2016; Sherr et al, 2014; Sirois et al, 2016; Smith et al, 2012; Smith and Wilkins, 2015) making PHIV a common infectious cause of perinatally-acquired developmental disability globally (Armstrong et al, 1993; Institute of Medicine, 2001; UNAIDS, 2015). Combination antiretroviral therapy (cART) for children with PHIV has resulted in substantial improvements in health with survival beyond childhood and reductions in morbidity and mortality (Brady et al, 2010; Gona et al, 2006; Hazra et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Lower total and regional grey matter brain volumes in youth with perinatally-acquired HIV infection: Associations with HIV disease severity, substance use, and cognition

Angeles

Williams

Huo

et al. 2017

Brain, Behavior, and Immunity

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Despite improved survival due to combination antiretroviral therapy (cART), youth with perinatally-acquired HIV (PHIV) show cognitive deficits and developmental delay at increased rates. HIV affects the brain during critical periods of development, and the brain may be a persistent reservoir for HIV due to suboptimal blood brain barrier penetration of cART. We conducted structural magnetic resonance imaging (sMRI) and cognitive testing in 40 PHIV youth (mean age=16.7 years) recruited from the NIH Pediatric HIV/AIDS Cohort Study (PHACS) who are part of the first generation of PHIV youth surviving into adulthood. Historical and current HIV disease severity and substance use measures were also collected. Total and regional cortical grey matter brain volumes were compared to a group of 334 typically-developing, HIV-unexposed and uninfected youth (frequency-matched for age and sex) from the Pediatric Imaging, Neurocognition, and Genetics (PING) study (mean age=16.1 years). PHIV youth had smaller (2.8 – 5.1%) total and regional grey matter volumes than HIV-unexposed and uninfected youth, with smallest volumes seen among PHIV youth with higher past peak viral load (VL) and recent unsuppressed VL. In PHIV youth, worse cognitive performance correlated with smaller volumes. This pattern of smaller grey matter volumes suggests that PHIV infection may influence brain development and underlie cognitive dysfunction seen in this population. Among PHIV youth, smaller volumes were also linked to substance use (alcohol use: 9.0 – 13.4%; marijuana use: 10.1 – 16.0%). In this study, collection of substance use information was limited to the PHIV cohort; future studies should also collect substance use information in controls to further address interactions between HIV and substance use on brain volume.

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Developmental challenges in HIV infected children—An updated systematic review

Cited by 71 publications

References 34 publications

Effectiveness of Spirulina Supplement and Selected Yogasanas on Quality of Life of Children With Hiv Infection

Effectiveness of Spirulina Supplement and Selected Yogasanas on Quality of Life of Children With Hiv Infection

A study protocol “saving futures: developing an integrated model of rehabilitation and paediatric HIV care to foster success at school”

Lower total and regional grey matter brain volumes in youth with perinatally-acquired HIV infection: Associations with HIV disease severity, substance use, and cognition

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