Developmental Changes in Cerebrospinal Fluid Concentrations of Monoamine-Related Substances Revealed With a Coulochem Electrode Array System

Takeuchi, Yoshihiro; Matsushita, Hiroko; Sakai, Hisahiro; Kawano, Hisashi; Yoshimoto, Kanji; Sawada, Tadashi

doi:10.1177/088307380001500415

Cited by 17 publications

(9 citation statements)

References 13 publications

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“…It is difficult to speculate about mechanisms underlying the finding of heterogeneous development across the subcortical brain, including across hemispheres; however the patterns may relate to the different rates of maturation of the dopaminergic and serotonergic pathways (Casey & Jones, ; Chambers et al ., ; Lambe, Krimer & Goldman‐Rakic, ; Takeuchi, Matsushita, Sakai, Kawano, Yoshimoto & Sawada, ) and the differential distribution of these receptors in the subcortical brain (Brown, Crane & Goldman, ). For example, the amygdala, a structure that is both functionally associated with serotinergic activity (Hariri, Mattay, Tessitore, Kolachana, Fera, Goldman, Egan & Weinberger, ) and has nuclei that are more densely populated with serotinergic receptors relative to the other regions described in this study (Pazos, Probst & Palacios, ), did not show developmental change.…”

Section: Discussionmentioning

confidence: 99%

Mapping subcortical brain maturation during adolescence: evidence of hemisphere‐ and sex‐specific longitudinal changes

Dennison

Whittle

Yücel

et al. 2013

Developmental Science

139

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Early to mid-adolescence is an important developmental period for subcortical brain maturation, but longitudinal studies of these neurodevelopmental changes are lacking. The present study acquired repeated magnetic resonance images from 60 adolescent subjects (28 female) at ages 12.5 and 16.5 years to map changes in subcortical structure volumes. Automated segmentation techniques optimized for longitudinal measurement were used to delineate volumes of the caudate, putamen, nucleus accumbens, pallidum, hippocampus, thalamus and the whole brain. Amygdala volumes were described using manual tracing methods. The results revealed heterogeneous maturation across the regions of interest (ROIs), and change was differentially moderated by sex and hemisphere. The caudate, thalamus and putamen declined in volume, more for females relative to males, and decreases in the putamen and thalamus were greater in the left hemisphere. The pallidum increased in size, but more so in the left hemisphere. While the left nucleus accumbens increased in size, the right accumbens decreased in size over the follow-up period. Increases in hippocampal volume were greater in the right hemisphere. While amygdala volume did not change over time, the left hemisphere was consistently larger than the right. These results suggest that subcortical brain development from early to middle adolescence is characterized by striking hemispheric specialization and sexual dimorphisms, and provide a framework for interpreting normal and abnormal changes in cognition, affect and behavior. Moreover, the differences in findings compared to previous cross-sectional research emphasize the importance of within-subject assessment of brain development during adolescence.

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Section: Discussionmentioning

confidence: 99%

Mapping subcortical brain maturation during adolescence: evidence of hemisphere‐ and sex‐specific longitudinal changes

Dennison

Whittle

Yücel

et al. 2013

Developmental Science

139

View full text Add to dashboard Cite

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“…The under-specialized reward system may be limited in adolescence in the ability to properly assess the valence (rewards and punishment) and value of incentives. Additionally, during adolescence there is greater activity in dopamine systems that surpasses that of inhibitory 5-HT systems resulting in a potential imbalance in reward and suppression mechanisms (Andersen, 2005; Chambers et al, 2003; Lambe, Krimer, & Goldman-Rakic, 2000; Takeuchi et al, 2000). The effects of reward on the cognitive control of eye movements could provide a model to test incentive processing in development and psychopathology.…”

Section: Development Of Voluntary Control Of Eye Movementsmentioning

confidence: 99%

Development of eye-movement control

Luna

Velanova

Geier

2008

Brain and Cognition

282

242

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Cognitive control of behavior continues to improve through adolescence in parallel with important brain maturational processes including synaptic pruning and myelination, which allow for efficient neuronal computations and the functional integration of widely distributed circuitries supporting top-down control of behavior. This is also a time when psychiatric disorders, such as schizophrenia and mood disorders, emerge reflecting a particularly vulnerability to impairments in development during adolescence. Oculomotor studies provide a unique neuroscientific approach to make precise associations between cognitive control and brain circuitry during development that can inform us of impaired systems in psychopathology. In this review, we first describe the development of pursuit, fixation, and visually-guided saccadic eye movements, which collectively indicate early maturation of basic sensorimotor processes supporting reflexive, exogenously-driven eye movements. We then describe the literature on the development of the cognitive control of eye movements as reflected in the ability to inhibit a prepotent eye movement in the antisaccade task, as well as making an eye movement guided by on-line spatial information in working memory in the oculomotor delayed response task. Results indicate that the ability to make eye movements in a voluntary fashion driven by endogenous plans shows a protracted development into adolescence. Characterizing the transition through adolescence to adult-level cognitive control of behavior can inform models aimed at understanding the neurodevelopmental basis of psychiatric disorders.

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“…The density of dopamine transporters, which function to remove DA from the synapse, has also been shown to peak during adolescence in the striatum (Meng et al, 1999). Furthermore, evidence indicates that during adolescence, there is relatively greater activity in dopamine systems than in inhibitory serotonin (5-HT) systems, potentially resulting in an imbalance in reward (DA-mediated) and suppression (5-HT-mediated) mechanisms (Takeuchi et al, 2000; Lambe et al, 2000; Ernst et al, 2006; Spear, 2000). In mesocortical pathways, non-human primate work has shown that DA inputs to prefrontal cortex (PFC) peak in adolescence (Rosenberg and Lewis, 1994; Rosenberg and Lewis, 1995; Spear, 2000).…”

Section: Brain Maturation During Adolescencementioning

confidence: 99%

The maturation of incentive processing and cognitive control

Geier

Luna

2009

Pharmacology Biochemistry and Behavior

192

152

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Understanding how immaturities in the reward system affect decision-making can inform us on adolescent vulnerabilities to risk-taking, which is a primary contributor to mortality and substance abuse in this age group. In this paper, we review the literature characterizing the neurodevelopment of reward and cognitive control and propose a model for adolescent reward processing. While the functional neuroanatomy of the mature reward system has been well-delineated, adolescent reward processing is just beginning to be understood. Results indicate that adolescents relative to adults demonstrate decreased anticipatory processing and assessment of risk, but an increased consummatory response. Such differences could result in suboptimal representations of reward valence and value and bias adolescent decision-making. These functional differences in reward processing occur in parallel with on-going structural and pharmacological maturation in the adolescent brain. In addition to limitations in incentive processing, basic cognitive control abilities, including working memory and inhibitory control, continue to mature during adolescence. Consequently, adolescents may be limited, relative to adults, in their abilities to inhibit impulsive behaviors and reliably hold 'on-line' comparisons of potential rewards/punishments during decisionmaking.

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Developmental Changes in Cerebrospinal Fluid Concentrations of Monoamine-Related Substances Revealed With a Coulochem Electrode Array System

Cited by 17 publications

References 13 publications

Mapping subcortical brain maturation during adolescence: evidence of hemisphere‐ and sex‐specific longitudinal changes

Mapping subcortical brain maturation during adolescence: evidence of hemisphere‐ and sex‐specific longitudinal changes

Development of eye-movement control

The maturation of incentive processing and cognitive control

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