Developmental changes in mesenteric artery reactivity in embryonic and newly hatched chicks

Moonen, Rob; Villamor, Eduardo

doi:10.1007/s00360-011-0589-8

Cited by 12 publications

(17 citation statements)

References 51 publications

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“…Transfusion has been shown to impair this postprandial increase in blood flow velocity in the superior MA (15). Circulating catecholamines (16,17), the sympathetic system, and endothelin (6) are considered to be primary constrictors of the mesenteric circulation. Therefore, we used NE and ET-1 as the constricting agents for isolated mesenteric arterial ring studies.…”

Section: Discussionmentioning

confidence: 99%

Packed red cell transfusions alter mesenteric arterial reactivity and nitric oxide pathway in preterm lambs

et al. 2013

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BACKGROUND Cases of necrotizing enterocolitis occurring within 48 h of packed red blood cell (PRBC) transfusions are increasingly being described in observational studies. Transfusion-associated gut injury is speculated to result from an abnormal mesenteric vascular response to transfusion. However, the mechanism of disruption of the balance between mesenteric vasoconstriction and relaxation following transfusion is not known. METHODS Preterm lambs (n = 16, 134 d gestation; term: 145–147 d) were delivered and ventilated for 24 h. All the lambs received orogastric feeds with colostrum. In addition, 10 of these lambs received PRBC transfusions. Vasoreactivity was evaluated in isolated mesenteric arterial rings using norepinephrine and endothelin-1 as vasoconstrictors. Endothelium-dependent (A23187, a calcium ionophore) and endothelium-independent (SNAP) nitric oxide (NO) donors were used as vasorelaxants. Mesenteric arterial endothelial NO synthase (eNOS), soluble guanylyl cyclase (sGC), and phosphodiesterase 5 (PDE5) mRNA analyses and protein assays were performed. RESULTS Transfusion with PRBC significantly increased mesenteric vasoconstriction to norepinephrine and endothelin-1 and impaired relaxation to A23187 and SNAP. Mesenteric arterial eNOS protein decreased following PRBC transfusion. No significant changes were noted in sGC and PDE5 mRNA or protein assays. CONCLUSION PRBC transfusion in enterally fed preterm lambs promotes mesenteric vasoconstriction and impairs vasorelaxation by reducing mesenteric arterial eNOS.

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Section: Discussionmentioning

confidence: 99%

Packed red cell transfusions alter mesenteric arterial reactivity and nitric oxide pathway in preterm lambs

et al. 2013

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“…Endothelial function has been mainly studied by the use of acetylcholine (ACh). In the chicken embryo, ACh induced an endothelium-dependent and, at least partially, NO-mediated relaxation of pulmonary (Villamor et al 2002), femoral (le Noble et al 2000Villamor et al 2002), mesenteric (Moonen & Villamor, 2011) and carotid arteries , as well as in the ductus arteriosus (Agren et al 2008). Interestingly, chronic isobaric hypoxia led to impairment of ACh-induced relaxation in the systemic (Ruijtenbeek et al 2003a,b;Villamor et al 2004;Van der Sterren et al 2009;Moonen et al 2012) but not in the pulmonary arteries (Villamor et al 2004).…”

Section: Of Incubationmentioning

confidence: 98%

“…; Villamor et al . ), mesenteric (Moonen & Villamor, ) and carotid arteries (le Noble et al . ), as well as in the ductus arteriosus (Agren et al .…”

Section: Introductionmentioning

confidence: 99%

The highs and lows of programmed cardiovascular disease by developmental hypoxia: studies in the chicken embryo

Itani

Salinas

Villena

et al. 2017

The Journal of Physiology

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It is now established that adverse conditions during pregnancy can trigger a fetal origin of cardiovascular dysfunction and/or increase the risk of heart disease in later life. Suboptimal environmental conditions during early life that may promote the development of cardiovascular dysfunction in the offspring include alterations in fetal oxygenation and nutrition as well as fetal exposure to stress hormones, such as glucocorticoids. There has been growing interest in identifying the partial contributions of each of these stressors to programming of cardiovascular dysfunction. However, in humans and in many animal models this is difficult, as the challenges cannot be disentangled. By using the chicken embryo as an animal model, science has been able to circumvent a number of problems. In contrast to mammals, in the chicken embryo the effects on the developing cardiovascular system of changes in oxygenation, nutrition or stress hormones can be isolated and determined directly, independent of changes in the maternal or placental physiology. In this review, we summarise studies that have exploited the chicken embryo model to determine the effects on prenatal growth, cardiovascular development and pituitary-adrenal function of isolated chronic developmental hypoxia.

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“…Among farm animals, the chicken has emerged as an important model organism, in fields as diverse as embryological development, immunology, oncology, virology, evolution, genetics, and genomics, and particularly as a model for other avian species. Studies of chicken SNPs have mainly focused on important economic characteristics, such as growth (Amills et al, 2003;Wang et al, 2011;Liu et al, 2012;Xie et al, 2012;Ahsan et al, 2013;Jin et al, 2013), carcass characteristics Uemoto et al, 2011;Lu et al, 2012;Boschiero et al, 2013;Sun et al, 2013), egg quality (Bennett et al, 2006;Fatemi et al, 2012), fatness Han et al, 2012), reproduction (Tang et al, 2010;Moonen and Villamor, 2011;Liu et al, 2012), and disease resistance (Legarra et al, 2011;Meydan et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Identification of single nucleotide polymorphisms in the ASB15 gene and their associations with chicken growth and carcass traits

Wang¹,

Jiang²,

Kang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. ASB15 is a member of the ankyrin repeat and suppressor of cytokine signaling box family, and is predominantly expressed in skeletal muscle. In the present study, an F 2 resource population of Gushi chickens crossed with Anka broilers was used to investigate the genetic effects of the chicken ASB15 gene. Two single nucleotide polymorphisms (SNPs) (rs315759231 A>G and rs312619270 T>C) were identified in exon 7 of the ASB15 gene using forced polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. One was a missense SNP (rs315759231 A>G) and the other was a synonymous SNP (rs312619270 T>C). The rs315759231 A>G polymorphism was significantly associated with body weight at birth, 12-week body slanting length, semi-evisceration weight, evisceration weight, leg muscle weight, and carcass weight (P < 0.05). The rs312619270 T>C polymorphism was significantly associated with body weight at birth, 4, 8, and 12-week body weight, 8-week shank length, 12-week breast bone length, 8 and 12-week body slanting length, breast muscle weight, and carcass weight (P < 0.05). Our results suggest that the ASB15 gene profoundly affects chicken growth and carcass traits.

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Developmental changes in mesenteric artery reactivity in embryonic and newly hatched chicks

Cited by 12 publications

References 51 publications

Packed red cell transfusions alter mesenteric arterial reactivity and nitric oxide pathway in preterm lambs

Packed red cell transfusions alter mesenteric arterial reactivity and nitric oxide pathway in preterm lambs

The highs and lows of programmed cardiovascular disease by developmental hypoxia: studies in the chicken embryo

Identification of single nucleotide polymorphisms in the ASB15 gene and their associations with chicken growth and carcass traits

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