Developmental changes in metabotropic glutamate receptor-mediated calcium homeostasis

Zirpel, Lance; Janowiak, Mary A.; Taylor, Dwan A.; Parks, Thomas N.

doi:10.1002/(sici)1096-9861(20000522)421:1<95::aid-cne6>3.0.co;2-5

Cited by 37 publications

(35 citation statements)

References 58 publications

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“…17,18 Although mGlu receptors regulate synaptic transmission, some of the subtypes (particularly, the mGlu5 receptor) are expressed at developmental stages that precede synaptic formation and are also found in nonneuronal tissues. [19][20][21] A specific role for mGlu5 receptors in developmental plasticity is suggested by numerous observations. For example, endogenous activation of mGlu5 receptors in immature cortical neurons generates calcium oscillations, 12 and homozygous null mutations of either mGlu5 receptors or phospholipase C-b1 disrupt the cytoarchitectural differentiation of 'barrels' in the mouse somatosensory cortex.…”

Section: Introductionmentioning

confidence: 99%

Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells

et al. 2005

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The use of neural progenitor cells (NPCs) is limited by the incomplete knowledge of the extracellular signals regulating their proliferation and survival. We report that cultured mouse NPCs express functional mGlu3 and mGlu5 metabotropic glutamate receptors. Pharmacological blockade of both receptors reduced NPC proliferation and survival, whereas activation of mGlu5 receptors substantially enhanced cell proliferation. Adult mice lacking mGlu5 receptors or treated with mGlu5 or mGlu3 receptor antagonists showed a dramatic reduction in the number of dividing neuroprogenitors present in the subventricular zone and in the dentate gyrus of the hippocampus. These data disclose a novel function of mGlu receptors and offer new potential strategies for the optimization of cell replacement therapy in neurodegenerative disorders.

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Section: Introductionmentioning

confidence: 99%

Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells

et al. 2005

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“…Thus, unlike some group III mGluR subtypes that disappear during early development (Elezgarai et al, 1999), the mGluR1a-CB1R signaling pathway may be relevant for hearing animals and not only during early development. Group I mGluRs may also have a neuroprotective role in setting physiological [Ca 2ϩ ] i levels (Zirpel and Rubel, 1996;Zirpel et al, 2000).…”

Section: Group I Mglur Modulation Of the Mntb Outputmentioning

confidence: 99%

Retroinhibition of Presynaptic Ca²⁺Currents by Endocannabinoids Released via Postsynaptic mGluR Activation at a Calyx Synapse

Kushmerick¹,

Price²,

et al. 2004

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“…Activity-dependent activation of Group I mGluRs (which includes two related proteins, mGluRs 1 and 5) releases Ca 2+ from intracellular stores in chick NM neurons by activating phospholipase C, which generates IP 3 [231]. This mGluR-mediated effect on calcium homeostasis develops in parallel with synaptic activity in NM [229] and has been shown to be necessary for the survival of many NM neurons [230,231]. It has recently been found that zinc is localized in chick cochlear nerve endbulbs (Fig.…”

Section: Metabotropic Glutamate Receptorsmentioning

confidence: 99%

Primary innervation of the avian and mammalian cochlear nucleus

Ryugo¹,

Parks²

2003

Brain Research Bulletin

115

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The auditory nerve of birds and mammals exhibits differences and similarities, but given the millions of years since the two classes diverged from a common ancestor, the similarities are much more impressive than the differences. The avian nerve is simpler than that of mammals, but share many fundamental features including principles of development, structure, and physiological properties. Moreover, the available evidence shows that the human auditory nerve follows this same general organizational plan. Equally impressive are reports that homologous genes in worms, flies, and mice exert the same heredity influences in man. The clear implication is that animal studies will produce knowledge that has a direct bearing on the human condition.

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Developmental changes in metabotropic glutamate receptor-mediated calcium homeostasis

Cited by 37 publications

References 58 publications

Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells

Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells

Retroinhibition of Presynaptic Ca²⁺Currents by Endocannabinoids Released via Postsynaptic mGluR Activation at a Calyx Synapse

Primary innervation of the avian and mammalian cochlear nucleus

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Developmental changes in metabotropic glutamate receptor-mediated calcium homeostasis

Cited by 37 publications

References 58 publications

Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells

Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells

Retroinhibition of Presynaptic Ca2+Currents by Endocannabinoids Released via Postsynaptic mGluR Activation at a Calyx Synapse

Primary innervation of the avian and mammalian cochlear nucleus

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Retroinhibition of Presynaptic Ca²⁺Currents by Endocannabinoids Released via Postsynaptic mGluR Activation at a Calyx Synapse