2002
DOI: 10.1097/00001756-200203250-00014
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Developmental changes in the orexin 2 receptor mRNA in hypoglossal motoneurons

Abstract: Hypothalamic orexin-containing neurons project to many CNS targets, including motoneurons. We assessed developmental changes in the expression of the orexin type 2 receptor (ORX2r) mRNA in hypoglossal (XII) motoneurons. Identified motoneurons were dissociated from 4- to 33-day-old rats and subjected to single-cell reverse transcription and PCR; nearly all contained the ORX2r mRNA. In 40 motoneurons studied using semi-nested PCR, and in another 39 subjected to quantitative, real-time PCR, the number of reverse-… Show more

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Cited by 47 publications
(34 citation statements)
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“…Orexinergic neurons projected to the cardiovascular centers (2, 9, 12, 15, 37) and respiratory centers (39,43) in the medulla oblongata and the spinal cord. Some of these nuclei may be involved in the elicitation of each feature of the defense response examined here.…”
Section: Discussionmentioning
confidence: 99%
“…Orexinergic neurons projected to the cardiovascular centers (2, 9, 12, 15, 37) and respiratory centers (39,43) in the medulla oblongata and the spinal cord. Some of these nuclei may be involved in the elicitation of each feature of the defense response examined here.…”
Section: Discussionmentioning
confidence: 99%
“…In rats, in situ hybridization histochemistry demonstrates the presence of Hcrt receptor mRNA expression in brain stem regions that correspond to V and XII motor nuclei (Marcus et al 2001). Furthermore, Volgin et al (2002) found that identified XII motoneurons express mRNA that encodes the Hcrt-2 receptor. Given Hcrt projections to cranial motoneurons and receptor expression on them, in combination, with the results presented here, we purpose that Hcrt plays a permissive role in regulating motoneuronal excitability.…”
Section: Hypocretin and Motor Outputmentioning
confidence: 98%
“…Our observations suggest that input from hypocretin synthesizing neurons somehow modulates chemotransduction on 5-HT-synthesizing neurons. The role of these cells may be complex, resulting from the direct influences of hypocretin (Marcus et al 2001;Volgin et al 2002;Young et al 2005) or the activity-dependent release or corelease of other transmitters such as glutamate from hypocretin neurons (Schone et al 2012(Schone et al , 2014. Although the projections from the lateral hypothalamus appear to influence CO 2 sensitivity in a number of nuclei (Deng et al 2007;Dias et al 2009;Nakamura et al 2007) and may themselves be chemosensitive (Williams et al 2007), their absence from our experimental preparation precludes chemotransduction at these cells from contributing to the present results.…”
Section: Lmx1bmentioning
confidence: 99%
“…The hypocretin system is anatomically linked with central chemosensory and respiratory nuclei (Fung et al 2001;Hagan et al 1999;Nakamura et al 2007;Volgin et al 2002;Young et al 2005). The functional consequences of such interactions and the specific effects on ventilation remain unclear (Corcoran et al 2010;Nakamura et al 2007;Young et al 2005;Zhang et al 2005).…”
mentioning
confidence: 99%