Developmental changes in the pattern of amino acid transport at the blood-brain barrier in rats

Lefauconnier, Jeanne-Marie; Trouvé, Renaud

doi:10.1016/0165-3806(83)90095-0

Cited by 51 publications

(26 citation statements)

References 29 publications

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“…injection. For the thse injection experiments, the infant rats were mainly used because (1) the blood brain barrier (BBB) in the infant period has been reported to have a greater permeability of neutral amino acids into the brain than the adult BBB (15), and (2) we have verified that systemic administration of D-and L-serine can efficiently cause a dramatic increase in the neocortical concentrations of the respective amino acids in the 8-day-old rats. NuSieve 3:1 agarose was from FMC Bioproducts (Rockland, ME).…”

Section: Methodsmentioning

confidence: 89%

Cloning of a -Serine-Regulated Transcript dsr-1 from the Rat Cerebral Cortex

Tsuchida

Yamamoto

Kajii

et al. 2001

Biochemical and Biophysical Research Communications

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Section: Methodsmentioning

confidence: 89%

Cloning of a -Serine-Regulated Transcript dsr-1 from the Rat Cerebral Cortex

Tsuchida

Yamamoto

Kajii

et al. 2001

Biochemical and Biophysical Research Communications

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“…It is known for example that in NKH CSF glycine levels are high before birth [26] and that CSF glycine levels can be higher in the newborn period than later [23]. This latter finding may reflect the fact that, at least in rats, glycine in the plasma can more easily enter the brain in newborn animals [15]. The neonatal brain may also be more susceptible to damage by glycine [16].…”

Section: Discussionmentioning

confidence: 93%

Difficulties in assessing the effect of strychnine on the outcome of non-ketotic hyperglycinaemia. Observations on sisters with a mild T-protein defect

et al. 1986

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Sisters with a mild variant of non-ketotic hyperglycinaemia resulting from a defect in the T-protein of the glycine cleavage system had different clinical outcomes. The older sister was ascertained at 6 months of age because of mental retardation. She received only brief treatment with sodium benzoate from 11-15 months and at 15 years of age is profoundly retarded and has epilepsy. The younger sister was diagnosed 36 h after birth, was treated with strychnine, sodium benzoate and arginine from the neonatal period and at 27 months of age is only moderately retarded and free of seizures. The possible role of strychnine in the improved outcome is discussed.

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“…1) for young IUGR animals. A decrease in the alanine transfer coefficient is certainly correlated to this amino acid transport system maturation (system alanine, serine, and cysteine), reported to be active for young rats and then reported to lose a preponderant role in alanine transfer along with BBB maturation (39).…”

Section: Discussionmentioning

confidence: 99%