1974
DOI: 10.1007/978-1-4684-3063-9_22
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Developmental Changes in the Responsivity of the Brain to Endogenous and Exogenous Factors

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(2 citation statements)
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“…There are a number of basic science results which suggest that hormonal change with age may be associated with altered neuronal function [217]. Thyroid hormones, in particular T3, have been documented to stimulate proliferation and differentiation of neurones in development [218]. Direct mechanisms for this interaction have been proposed [219], in addition to indirect hypotheses mediated by nerve growth factor synthesis [220].…”
Section: Protective Factors In Brain Ageingmentioning
confidence: 99%
See 1 more Smart Citation
“…There are a number of basic science results which suggest that hormonal change with age may be associated with altered neuronal function [217]. Thyroid hormones, in particular T3, have been documented to stimulate proliferation and differentiation of neurones in development [218]. Direct mechanisms for this interaction have been proposed [219], in addition to indirect hypotheses mediated by nerve growth factor synthesis [220].…”
Section: Protective Factors In Brain Ageingmentioning
confidence: 99%
“…Perhaps the best studied hormone in ageing is oestrogen because of the natural decrease in concentration in women after menopause. Oestrogens, like other hormones, can regulate the level of neuronal plasticity in the brain via direct and indirect routes [218]. Hypoestrogenism has been linked to age‐related cognitive change and a higher risk of AD in postmenopausal women [224], making the efficacy of hormone replacement therapy an important issue.…”
Section: Protective Factors In Brain Ageingmentioning
confidence: 99%