Developmental Changes in Uptake of Radioactivity by the Ovaries, Pituitary and Uterus After 125i-Labelled Human Chorionic Gonadotrophin Administration in Rats

Presl, J; Pospíšil, J; Figarová, V; Wagner, Verena

doi:10.1677/joe.0.0520585

Cited by 26 publications

(11 citation statements)

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“…The stimulatory effect of exoge nous gonadotropins becomes evident after the 20th postnatal day. Presl et al (20) in in vivo experiments found little ovarian uptake of iodinated HCG in 5-day-old rats with considerable increased during the 2nd week.…”

Section: Discussionmentioning

confidence: 93%

Ontogenic Development of the Responsiveness in cAMP Synthesis to LH and PGE<sub>1</sub> and Gonadotropin Receptors in the Rat Ovary

Kolena¹

1976

Neonatology

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Incubation of ovaries derived from rats aged 9, 13, 16, and 20 days with LH resulted in a significant rise in cAMP synthesis. The ovaries from 2- and 5-day-old rats were, however, unresponsive to stimulation by LH. By contrast, prostaglandin E₁ (PGE₁) evoked a sharp response in ovarian synthesis of cAMP even in 2-day-old rats. In order to determine why neonatal ovaries do not respond to LH, gonadotropic receptors have been studied. HCG binding sites were present in homogenates of untreated and gonadotropins primed rat ovaries. The specificity of this ¹²⁵I-HCG binding was demonstrated by the competition of unlabeled HCG and LH for binding sites and failure of such binding to occur in specimens obtained from control tissues. FSH, ACTH and growth hormone were not able to compete significantly for ¹²⁵I-HCG binding. The HCG receptor is present in ovaries during the whole postnatal period. The results suggest that the unresponsiveness of neonatal rat ovaries to LH is not caused by later maturation of gonadotropic receptors.

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Section: Discussionmentioning

confidence: 93%

Ontogenic Development of the Responsiveness in cAMP Synthesis to LH and PGE<sub>1</sub> and Gonadotropin Receptors in the Rat Ovary

Kolena¹

1976

Neonatology

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“…It has been suggested that follicular development is independent of pituitary control during the early stages of postnatal development (Price and Ortiz, 1944 ;Paesi, 1949 ;Hertz, 1963 (Eshkol et al, 1970 ;Schuchner and Monastirsky, 1973 ;Schwartz, 1974 ;Schwartz et al, 1974 ;Anderson et al, 1976 ;Purandare et al, 1976 (Falck, 1953 ;Lamprecht et ai., 1973 ;HunzickerDunn and Birnbaumer, 1976 ;Kolena, 1976a, b ;Lamprecht et al, 1976), at a time when autoradiographic studies of 125 1-hCG binding (Presl et al, 1972) (Friend, 1977). They soon decline and remain low during the first week (Meijs-Roelofs et al, 1973 ;Dohler and Wuttke, 1975 (1976,1979), who reported that the enzymatic system necessary for ovarian cyclic AMP formation and oestradiol biosynthesis in mice develops normally following gonadotrophin deprivation from birth.…”

Section: Introductionmentioning

confidence: 99%

“…The lack of a steroidogenic response to LH observed in rat ovaries during the early postnatal period could have been due to an absence of specific binding sites for the hormone (Presl et al, 1972 ;Siebers et al, 1977a, b (Rosen and Rosen, 1968 ;Schmidt et al, 1970 ;Perkins, 1973 (Lamprecht et al, 1973(Lamprecht et al, , 1976 (Wicks, 1974 ;Di Marco and Oliver, 1978).…”

Section: Introductionmentioning

confidence: 99%

Ontogeny of responsiveness to gonadotrophins and prostaglandin E in the neonatal rat ovary

Lamprecht¹,

Funkenstein²,

Nimrod³

1979

Ann. Biol. anim. Bioch. Biophys.

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Summary. The Ovaries of 4-day old rats cultured for 2-12 days in medium without hormonal supplementation produced small and decreasing amounts of steroids. The addition of LH did not alter progesterone production during the first 4 days of culture but significantly stimulated it during Days 4-8 of culture. FSH and testosterone (1 fL g/ml) had no effect on their own, but when FSH or testosterone were added together with LH, progesterone production during Days 4-10 of culture was greatly enhanced. The acquisition of responsiveness to LH did not depend on previous exposure to the hormone, since a full response in progesterone production to LH was obtained in the ovaries after 4-8 days of culture without LH addition.Production of oestradiol-17P was slightly enhanced by LH during Days 4-10 of culture.FSH had no effect on its own, but augmented the effect of LH. The addition of testosterone alone significantly stimulated oestradiol production even during the first 2 days. This effect of exogenous testosterone was greatly enhanced by FSH. It is concluded that the ability of the neonatal ovary to respond to LH by the eighth day post partum is acquired by an autonomous developmental process and is not dependent upon previous exposure to gonadotrophins and steroid hormones. However, once sensitivity to the gonadotrophin is attained, steroidogenesis is controlled by an interplay of gonadotrophins and steroid hormones. In contrast to LH, the ovaries are responsive to PGE z at birth.Introduction.

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“…Contrary to the situation in the testis, in the rat ovary the HCG-receptorprotein is not constitutively expressed during development. Ovarian tissues of prenatal, newborn and 5-day old rats do not specifically bind HCG (Presl et al, 1972 ;Siebers et al, 1977). HCG receptors in the rat ovary are first detected during postnatal development between days 6 and 8, which coincides with the onset of LH or HCG sensitivity of the postnatal ovary (Lamprecht et al, 1973 ;Presl et al, 1969 ;Lamprecht et al, 1976 (Siebers et al, 1977).…”

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confidence: 96%

“…

(Presl et al, 1972 ;Siebers et al, 1977). The ovaries first become sensitive to endogenous or exogenous LH or HCG with respect to cAMP production and steroid biosynthesis, with the appearance of the specific LH/HCG receptor between 6 and 8 days of age (Lamprecht et at., 1973(Lamprecht et at., ,1976 (Cuatrecasas, 1971).

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mentioning

confidence: 99%

LH/HCG receptors of the ovary during early postnatal development

Müller¹,

Engel²,

Siebers³

1979

Ann. Biol. anim. Bioch. Biophys.

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(Presl et al., 1972 ;Siebers et al., 1977). The ovaries first become sensitive to endogenous or exogenous LH or HCG with respect to cAMP production and steroid biosynthesis, with the appearance of the specific LH/HCG receptor between 6 and 8 days of age (Lamprecht et at., 1973(Lamprecht et at., ,1976 (Cuatrecasas, 1971). However, the mechanism of receptor activation is unknown. From the observation that bovine brain gangliosides (Lee et al., 1976)

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Developmental Changes in Uptake of Radioactivity by the Ovaries, Pituitary and Uterus After 125i-Labelled Human Chorionic Gonadotrophin Administration in Rats

Cited by 26 publications

References 4 publications

Ontogenic Development of the Responsiveness in cAMP Synthesis to LH and PGE<sub>1</sub> and Gonadotropin Receptors in the Rat Ovary

Ontogenic Development of the Responsiveness in cAMP Synthesis to LH and PGE<sub>1</sub> and Gonadotropin Receptors in the Rat Ovary

Ontogeny of responsiveness to gonadotrophins and prostaglandin E in the neonatal rat ovary

LH/HCG receptors of the ovary during early postnatal development

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