Developmental changes of brainstem auditory evoked potentials (BAEPs) in normal human subjects from infants to young adults

Mochizuki, Yasuhiro; Go, Tohshin; Ohkubo, Hideo; Tatara, Takako; Motomura, Teruyuki

doi:10.1016/s0387-7604(82)80006-5

Cited by 57 publications

(16 citation statements)

References 16 publications

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“…Not all studies included information on how, or even if, audiometric or tympanometric data were obtained before obtaining ABRs. In addition, a lack of control in gender of subject populations could explain, at least in part, the noted ABR differences in previous studies (McClelland & McCrea, 1979;Mochizuki, Ohkubo, Tatara, & Motomura, 1982;O'Donovan, Beagley, & Shaw, 1980). In summary, the ABR data currently available do not provide clear evidence for brain stem dysfunction in individuals with autism.…”

Section: Introductionmentioning

confidence: 86%

Auditory Characteristics of Children with Autism

et al. 2006

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Objectives: The objectives of this study were (1) to describe the auditory characteristics of children with autism relative to those of typically developing children and (2) to describe the test-retest reliability of behavioral auditory test measures with this population of children with autism.Design: Audiometric data were obtained from 22 children diagnosed with autism and 22 of their typically developing peers. The audiologic test battery consisted of behavioral measures (i.e., visual reinforcement audiometry, tangible reinforcement operant conditioning audiometry, and conditioned play audiometry) and physiological measures (auditory brain stem response audiometry, distortion product otoacoustic emissions, and acoustic reflexes).Results: Children with autism had physiologic test results equivalent to their typically developing counterparts. That is, no differences in auditory brain stem response audiometry, distortion product otoacoustic emissions, or acoustic reflex results were noted between the children with autism and typically developing children. However, behavioral measures revealed that about half of the children diagnosed with autism presented pure-tone averages outside of normal limits (i.e., >20 dB HL), although their response thresholds to speech were within normal limits. All behavioral test results were within normal limits (i.e., <20 dB HL) for the typically developing children. In addition, test-retest variability was typically 15 dB or greater for children with autism as compared with variability of 10 dB or less for most of the typically developing children. Conclusions:Children with autism demonstrated essentially equivalent results on a battery of physiological auditory tests as those obtained from typically developing children. However, on average, behavioral responses of children with autism were elevated and less reliable relative to those of typically developing children. Furthermore, approximately half of the children with autism demonstrated behavioral pure-tone averages outside of the normal hearing range (i.e., >20 dB HL) despite having normal to near-normal hearing sensitivity as determined by other audiometric measures.

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Section: Introductionmentioning

confidence: 86%

Auditory Characteristics of Children with Autism

et al. 2006

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“…In a two-level HLM analysis, level one provided parameters of change using an asymptotic model of decay. The asymptote was based on the observed mean CCT value of the nonanemic control group in the follow-up, and the value at birth was obtained from standard sources (4,23). Level two of the model tested for significant differences in the change parameters between anemic and nonanemic groups, controlling for gestational age and birth weight.…”

Section: Subjectsmentioning

confidence: 99%

“…For example, dramatic decreases in latencies in auditory and visual evoked potentials in infancy are often used to index the overall intactness and maturation of the CNS. Progressively shorter latencies until adult levels are achieved are thought to reflect the increasing speed of transmission through sensory pathways, resulting in large part from increased myelination of the auditory and optic nerves and at the intracerebral level (1)(2)(3)(4)(5).…”

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confidence: 99%

Iron Deficiency Anemia in Infancy: Long-Lasting Effects on Auditory and Visual System Functioning

et al. 2003

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Evoked potentials provide noninvasive measures of nerve transmission and CNS functioning. Auditory brainstem responses (ABR) and visual evoked potentials (VEP) show dramatic changes in infancy, largely as a result of progressive myelination. Because iron is required for normal myelination, pathway transmission in these sensory systems might be affected by early iron deficiency. We previously reported evidence to that effect: infants with iron-deficiency anemia (IDA) had slower transmission through the auditory brainstem pathway, uncorrected by iron therapy. To determine long-term effects, ABR and/or VEP of healthy Chilean children who were treated for IDA or were nonanemic in infancy were compared at approximately 4 y of age. Absolute latencies for all ABR waves and interpeak latencies (except I-III interval) were significantly longer in former IDA children. Longer latency was also observed for the P100 wave on VEP. The magnitude of differences was large-about 1 SD. These findings, with differences in latencies but not amplitudes, further support the hypothesis that IDA in infancy alters myelination and provide evidence that effects on transmission through the auditory and visual systems can be long lasting. Subtle changes in sensory pathway transmission might be an underlying mechanism for the derailment of other developmental aspects in early IDA. Neurophysiologic methodologies are noninvasive approaches that can provide information about the functional integration of the CNS. For example, dramatic decreases in latencies in auditory and visual evoked potentials in infancy are often used to index the overall intactness and maturation of the CNS. Progressively shorter latencies until adult levels are achieved are thought to reflect the increasing speed of transmission through sensory pathways, resulting in large part from increased myelination of the auditory and optic nerves and at the intracerebral level (1-5).ABR represent the progressive activation of different levels of the auditory pathway: wave I is generated peripherally in the auditory nerve, wave III reflects the firing of axons exiting the cochlear nuclear complex, and wave V reflects an action potential generated by axons from the lateral lemniscus (6, 7). We recently reported the use of ABR to determine the effects of early IDA on the functional development of the auditory system (8). Six-month-old Chilean infants with IDA tended to show longer latencies than controls, indicating slower transmission through the brainstem portion of the auditory pathway. Differences became pronounced at 12 and 18 mo, despite iron therapy. Because iron is required for the functioning of several neurotransmission systems, myelination, and neuronal metabolic activity, different processes may relate to these lasting ABR abnormalities. However, the findings of differences in latency but not amplitude and more effects on the central (versus peripheral) portion of the auditory pathway appeared to be strong support for the hypothesis that impaired myelination was the explana...

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“…Various parameters of the ABRs are known to change as a function of age or stimulus intensity, thus providing a useful tool to evaluate hearing threshold [Hecox and Galambos, 1974;Roncagliolo et al, 1983;Thivierge and Coté, 1990] and maturity or neurological status of auditory brainstem structures [Salamy et al, 1975;Starr and Hamilton, 1976;Stockard and Rossiter, 1977;Starr, 1978;Mochizuki et al, 1982;Lauffer and Wenzel, 1990;Roncagliolo et al, 1994]. During development the several waves of ABRs progressively increase in amplitude and decrease in both absolute and interpeak latencies (IPLs) [Salamy and McKean, 1976;Starr et al, 1977;Mochizuki et al, 1982;Salamy et al, 1982;Vles et al, 1987;LinaGranade et al, 1993;Ferber-Viart et al, 1996;Roncagliolo et al, 1998]. These features reveal a developing synchrony in the discharges of component fibers and an increase in their conduction velocity due to myelination.…”

Section: Introductionmentioning

confidence: 99%

Progressive Deterioration of Central Components of Auditory Brainstem Responses during Postnatal Development of the Myelin Mutant <i>taiep</i> Rat

Roncagliolo

Benítez²,

Eguíbar³

2000

Audiol Neurotol

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Auditory brainstem responses (ABRs) were evaluated during the postnatal development (P10–P180) of taiep rats, neurological mutants characterized by early abnormal myelin development and subsequent demyelination of the CNS. The disorder is produced by an autosomal recessive mutation trait that affects the oligodendrocytes but not the Schwann cells. After onset of ABRs (P12–P14), taiep rats and their nonaffected heterozygous littermates that served as controls showed a similar pattern of maturation for wave I. The central waves (In–IV) showed significantly longer latencies in the mutants. By P60–P180, the later waves (III and IV) were frequently difficult to discern. From the onset of ABRs, the interpeak latency I–IV, corresponding to the central conduction time (CCT) of the auditory pathway, showed in taiep rats significantly longer values than controls. After an initial reduction, proportional to that of control rats, the CCT value increased progressively during the second month of the mutants’ lives. The electrophysiological results of the present study strongly support the hypothesis that mutation in the taiep rat impairs neuromaturation of the central auditory pathway in the brainstem by affecting the myelination process in the CNS.

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Developmental changes of brainstem auditory evoked potentials (BAEPs) in normal human subjects from infants to young adults

Cited by 57 publications

References 16 publications

Auditory Characteristics of Children with Autism

Auditory Characteristics of Children with Autism

Iron Deficiency Anemia in Infancy: Long-Lasting Effects on Auditory and Visual System Functioning

Progressive Deterioration of Central Components of Auditory Brainstem Responses during Postnatal Development of the Myelin Mutant <i>taiep</i> Rat

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