Developmental characteristics of brain catecholamines and tyrosine hydroxylase in the rat: effects of 6‐hydroxydopamine

Breese, George R.; Traylor, T. Dennis

doi:10.1111/j.1476-5381.1972.tb07257.x

Cited by 200 publications

(44 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subjects also received a 1-hour pretreatment with desipramine (20 mg/kg, given IP), to protect norepinephrine-containing neurons (Breese and Traylor 1972). Previous studies have demonstrated that striatal dopamine is reduced by greater than 90% with this treatment, with no reduction in brain levels of norepinephrine or serotonin (Breese et al 1984a).…”

Section: Lesioning Of Dopamine-containing Neurons In Neonate Ratsmentioning

confidence: 99%

Effect of Olanzapine on Functional Responses from Sensitized D1-Dopamine Receptors in Rats with Neonatal Dopamine Loss

Moy

Knapp

Breese

2001

Neuropsychopharmacology

View full text Add to dashboard Cite

(Breese et al. 1985a,b). For example, neonate-lesioned animals have increased locomotion following treatment with SKF-38393, a D 1 -DA receptor agonist, at doses that have minimal impact on control rats (Breese et al. 1985a,b). Repeated treatment with D 1 -DA agonists can lead to extremely high rates of activity in lesioned rats, and this "priming" effect can still be observed 6 months after the chronic drug treatment (Breese et al. 1985b;Criswell et al. 1989b). Supersensitivity of D 1 -DA receptors in neonatal-6-OHDA rats has also been linked to stereotyped responses and self-injurious behavior (SIB) following treatment with L-Dopa or apomorphine, suggesting that these animals can provide a valuable model for the self-injury and DA loss associated with Lesch-Nyhan disease (Breese et al. 1984a,b), a metabolic disorder primarily observed in male children (Lesch and Nyhan 1964).Paradoxically, although the aberrant responses in the neonate-lesioned rats can be completely blocked with selective D 1 -DA receptor antagonists (Breese et al. 1985a), these animals are remarkably subsensitive to haloperidol, even at doses which induce catalepsy in normal controls and in rats given 6-OHDA as young adults (Bruno et al. 1985;Duncan et al. 1987). Similarly, treatment with typical antipsychotic agents does not prevent the painful self-injury that occurs in LeschFrom the Departments of Psychiatry (SSM, DJK, GRB), Anesthesiology (GRB) and Pharmacology (GRB), Skipper Bowles Center For

show abstract

Section: Lesioning Of Dopamine-containing Neurons In Neonate Ratsmentioning

confidence: 99%

Effect of Olanzapine on Functional Responses from Sensitized D1-Dopamine Receptors in Rats with Neonatal Dopamine Loss

Moy

Knapp

Breese

2001

Neuropsychopharmacology

View full text Add to dashboard Cite

show abstract

“…Approximately 1 week prior to delivery, pregnant females were individually housed in plastic cages with wood chip bedding. Delivered pups were treated intracisternally with 100 μg 6-OHDA in 10 μl saline (0.5% ascorbic acid) under ether anesthesia (Breese and Traylor 1972;Smith et al 1973). Litters were limited to ten pups.…”

mentioning

confidence: 99%

Enhanced muscimol-induced behavioral responses after 6-OHDA lesions: relevance to susceptibility for self-mutilation behavior in neonatally lesioned rats

et al. 1987

Self Cite

View full text Add to dashboard Cite

Adult rats lesioned with 6-hydroxydopamine (6-OHDA), either as neonates or as adults, demonstrated increased turning, compared to unlesioned controls, when muscimol was unilaterally microinjected into the substantia nigra reticulata (SNR). At the higher doses of muscimol, the lesioned rats were so intensely lateralized that circling was impeded. These data suggest a functional supersensitivity of receptors associated with GABA function in the SNR of 6-OHDA-lesioned rats. When 30 ng muscimol was administered bilaterally into the SNR, self-mutilation behavior (SMB) was observed in 2/11 of the control unlesioned rats, in 0/8 adult 6-OHDA-lesioned rats, and in 11/11 of the neonatally-lesioned rats tested. The ability of muscimol to produce SMB in the rats lesioned as neonates was dose related. Behavioral observations indicated that behaviors associated with SMB (self-biting and taffy pulling) were present in neonatal, but not adult lesioned rats. Behavioral responses to dopamine agonist administration were also different between rats lesioned as neonates and those lesioned as adults with 6-OHDA. These data support the view that lesions of dopaminergic neurons cause an increased functional responsiveness of receptors acted upon by muscimol in the SNR, and that the increased susceptibility for SMB in neonatally lesioned rats is determined by neurons distal to the GABA receptor complex in the SNR. KeywordsMuscimol; Substantia nigra reticulata; Self-mutilation behavior; 6-Hydroxydopamine-neonatal lesion; 6-Hydroxydopamine-adult lesion; Turning behavior; Behavior, muscimol-induced; SKF-38393; LY-171555; L-dopa; Monoamine metabolites There is considerable evidence implicating dopaminergic mechanisms in motor function (Hornykiewicz 1973). In addition, GABA-containing neurons in the striatum also appear to play a significant role in motor control (Dray 1980;Graybiel and Ragsdale 1983;McGeer et al. 1984). These striatal GABAergic projections have been found to terminate in both segments of the globus pallidus as well as in the zona reticulata of the substantia nigra (SNR) (Fonnum etal. 1978;Preston et al. 1980;Scheel-Kruger et al. 1981). Unilateral administration into SNR of drugs which are associated with GABA receptor function all cause contralateral turning (Scheel-Kruger etal. 1977;Waddington 1978;Waddington and Cross 1979;McDevitt and Yunger 1982). In addition, GABA-mimetics microinjected bilaterally into the SNR or other terminal regions associated with striatal GABA efferents induce behaviors which resemble the effects induced by dopamine. These data led to the hypothesis that GABA efferents from the striatum act as secondary mediators of behaviors triggered by dopamine receptor stimulation (Scheel-Kruger et al. 1977 Waddington 1978a, b).There are several observations suggesting that disruption of the function of GABA efferents from the striatum results in a change in receptor function in the SNR. For example, Pan et al. (1983) found that destruction of GABA efferents increased the number of muscimol binding...

show abstract

“…For example, regional studies during development indicate that forebrain NE, DA, and their related enzymes approach adult levels at approximately 45 days of age (Porcher & Heller, 1972) and in the hippocampus, amygdala, and hypothalamus NE increases by 2000/0400% from 10 to 51 days of age (Weiner & Ganong, 1972). Whole brain NE, DA, and tyrosine hydroxylase increase approximately 60% from 10-40 days of age and remain relatively constant thereafter (e.g., Breese & Traylor, 1972). Catecholamines are also more sensitive to the depleting action of reserpine and tetrabenazine in 11-and 23-dav-old rats than in adults *This research was supported by Grant MH24384-01 to Joaquin M. Fuster and Richard H. Bauer and by personal funds of the authors.…”

mentioning

confidence: 99%

Differential effects of d-amphetamine in mature and immature rats

Bauer

Duncan

1975

Psychobiology

View full text Add to dashboard Cite

Twenty-eight-to 33-and 120-to 140-day-old male Sprague-Dawley rats were injected with physiological saline, 2.0, or 5.0 mg/kg d-amphetamine. Thirty minutes after the injection, they explored an open field for 8 min and were then trained in a one-way avoidance task. Mature animals were more active in the inner portion of the open field following 2.0 mg/kg and acquired the avoidance task more rapidly than those given saline or 5.0 mg/kg. Neither drug dose altered activity or avoidance of immature animals. Both mature and immature rats had shorter escape latencies to footshock following the drug. Differential effects of d-amphetamine in mature and immature animals are probably due to developmental changes in brain norepinephrine and/or dopamine.Very few studies have compared the behavioral effects of drugs in mature and immature animals, in spite of the fact that levels of some central nervous system chemicals altered by drugs differ in mature and immature animals. In one of the few reports comparing different age groups treated with d-amphetamine (d-A), Sofia (1969) found that 1.0 mg/kg increased activity of 32-day-old rats, but that this increase was less than in mature rats. Although no statistics were reported, Campbell, Lytle, and Fibiger (I 969) concluded that doses of .25-8 .0 mg/kg d-A produced similar activity increases in 10-, 15-,20-, 25-, and lOO-day-old rats.

show abstract

Developmental characteristics of brain catecholamines and tyrosine hydroxylase in the rat: effects of 6‐hydroxydopamine

Cited by 200 publications

References 25 publications

Effect of Olanzapine on Functional Responses from Sensitized D1-Dopamine Receptors in Rats with Neonatal Dopamine Loss

Effect of Olanzapine on Functional Responses from Sensitized D1-Dopamine Receptors in Rats with Neonatal Dopamine Loss

Enhanced muscimol-induced behavioral responses after 6-OHDA lesions: relevance to susceptibility for self-mutilation behavior in neonatally lesioned rats

Differential effects of d-amphetamine in mature and immature rats

Contact Info

Product

Resources

About