Developmental Defects of the Teeth and Their Hard Tissues

Kotsanos, Nikolaos; Papagerakis, Pétros; Sarnat, H; Bloch‐Zupan, Agnès

doi:10.1007/978-3-030-78003-6_17

Cited by 3 publications

(4 citation statements)

References 127 publications

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“…According to the existing literature [7,10,17], discoloration significantly affects a child's desire to smile and laugh, thus influencing their social interactions. The results of this study indicate that most participating parents preferred to seek dental consultation for discolorations caused by chromogenic bacteria, hypomineralization, and tooth caries in both primary and permanent teeth, suggesting a high level of parental awareness and perception, which could be attributed to the fact that most participants had a high level of education, primarily at the university level.…”

Section: Discussionmentioning

confidence: 99%

“…Comparatively, children and adolescents can also experience discoloration in their primary and permanent teeth, but unlike adults, internal factors rather than external factors are primarily responsible for such discoloration [4,5]. Internal factors include structural disorders and discoloration from pharmaceutical use during pregnancy or early infancy [6,7], while external factors contributing to discoloration include chromogenic bacteria, traumatic dental injuries, poor oral hygiene, caries and pulp necrosis [4,5,[8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Do hypomineralized teeth affect parents' emotional states and attitudes more than other discoloration conditions?

2023

Journal of Clinical Pediatric Dentistry

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Discoloration poses a significant esthetic issue, and parents’ opinions and emotional states may vary regarding different types of discoloration, such as molar incisor hypomineralization, caries or chromogenic bacteria. This study aimed to assess parent’s emotional state and attitudes towards discoloration in primary and permanent teeth. A two-part questionnaire was designed, consisting of questions about demographic data and simulated visuals of different primary and permanent teeth discoloration conditions. The Visual Analog Scale (VAS) was used to determine the emotional state, while parents’ attitudes towards dental consultation for each simulated visual were determined using statements such as “Absolutely yes”; “Yes”; “I don’t have an idea”; “No”; “Absolutely no”. The simulated visuals included cases of “caries with cavitation”, “yellow-brown hypomineralized area”, “white hypomineralized area” and “chromogenic bacteria”. The questionnaire was distributed to 300 parents through online communication channels. Categorical variables were analyzed using Pearson chi-square, with statistical significance set as p < 0.05. A total of 230 parents completed the questionnaire. The highest VAS scores and the highest percentage of “Absolutely yes” responses were observed for “caries with cavitation” in both primary (77.8%, 81.7%) and permanent (60.4%, 94.3%) teeth. Additionally, statistically significant differences were found in the VAS scores for chromogenic bacteria (p = 0.04), caries with cavitation (p = 0.005), white hypomineralized area (p = 0.01) and yellow-brown hypomineralized area (p = 0.02). Comparatively, parental preferences showed statistically significant differences for chromogenic bacteria (p = 0.01), caries with cavitation (p = 0.01), yellow-brown hypomineralized area (p = 0.01) and white hypomineralized area (p = 0.004). Parents displayed stronger emotional responses towards “caries with cavitation” compared to hypomineralization and chromogenic bacteria discolorations and expressed a positive attitude towards seeking dental consultation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Do hypomineralized teeth affect parents' emotional states and attitudes more than other discoloration conditions?

2023

Journal of Clinical Pediatric Dentistry

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“…The families in this subgroup displayed an autosomal recessive inheritance pattern. Rarely, hypomaturation and hypocalcification are present with diastemas, restorations, and susceptibility to temperature fluctuations Besides opaque, thin, and coarse enamel [27,28]. Taurodontism is a dental anomaly caused by the apical displacement of the pulpal floor, an expanded pulp chamber, and a lack of constriction at the cemento-enamel junction.…”

Section: Enamel and Dentin-pulp Complexmentioning

confidence: 99%

Hereditary Tooth Anomalies: Amelogenesis Imperfecta, Dentinogenesis Imperfecta, Dentine Dysplasia

El Elhaj

2024

Enamel and Dentin-Pulp Complex

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Amelogenesis imperfecta (AI), dentinogenesis imperfecta (DI), and dentin dysplasia (DD) are hereditary illnesses that affect the growth and architecture of teeth’s hard tissues (enamel and dentine). These diseases present clinical symptoms such as tooth discoloration, enamel/dentine abnormalities, and enhanced tooth sensitivity. AI is defined by teeth enamel flaws, while DI is characterized by anomalies in dentin development, leading to opalescent or yellow-brown teeth, greater translucency, and a higher risk of fractures. DD is less prevalent than AI or DI. The genetic basis of DD, DI, and AI is derived from gene alterations. Mutations in the DSPP, DMP1, COL1A1, and COL1A2 genes are linked to DI, while the DSPP, DMP1, and COL1A2 genes are the cause of DD. Family genetic history was used to detect genetic mutation and confirm diagnosis, with treatment options including endodontic therapy, restorative dentistry, and preventative treatments as in fluoride therapy and oral hygiene guidelines. Early diagnosis and effective treatment are essential for enhancing oral health and quality of life.

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“…Third molars or wisdom teeth are the last teeth to develop, are considered rudimentary and are routinely extracted, making them the most suitable candidate to collect tooth germs from. However, the average age of the initiation of third molar mineralization is between 7 and 10 years old, which would require tooth germs to be extracted before this point to develop bioengineered tooth germ [ 79 – 81 ]. Thus, the application of the bioengineered tooth germ technology for human biological tooth replacement requires further advances in obtaining postnatal dental stem cell sources, which can be guided toward a cap stage phenotype.…”

Section: Main Textmentioning

confidence: 99%

From Pluripotent Stem Cells to Organoids and Bioprinting: Recent Advances in Dental Epithelium and Ameloblast Models to Study Tooth Biology and Regeneration

Hermans,

Hasevoets,

Vankelecom

et al. 2024

Stem Cell Rev and Rep

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Ameloblasts are the specialized dental epithelial cell type responsible for enamel formation. Following completion of enamel development in humans, ameloblasts are lost and biological repair or regeneration of enamel is not possible. In the past, in vitro models to study dental epithelium and ameloblast biology were limited to freshly isolated primary cells or immortalized cell lines, both with limited translational potential. In recent years, large strides have been made with the development of induced pluripotent stem cell and organoid models of this essential dental lineage – both enabling modeling of human dental epithelium. Upon induction with several different signaling factors (such as transforming growth factor and bone morphogenetic proteins) these models display elevated expression of ameloblast markers and enamel matrix proteins. The advent of 3D bioprinting, and its potential combination with these advanced cellular tools, is poised to revolutionize the field – and its potential for tissue engineering, regenerative and personalized medicine. As the advancements in these technologies are rapidly evolving, we evaluate the current state-of-the-art regarding in vitro cell culture models of dental epithelium and ameloblast lineage with a particular focus toward their applicability for translational tissue engineering and regenerative/personalized medicine. Graphical Abstract Future perspectives for in vitro modeling of dental epithelium and ameloblasts. Development of iPSC and organoid models that can reliably generate dental epithelium and ameloblast-like cells, together with advances in 3D bioprinting, provide promising tools for enamel research. Advanced models will provide new avenues for development of enamel repair/regeneration approaches, for testing of dental materials or drugs, studying host-pathogen and/or cell-cell interactions, in vitro modeling of enamel diseases (e.g. amelogenesis imperfecta) and developing novel insights in fundamental tooth biology (e.g. regulation of amelogenesis, lineage specification). Abbreviations: iPSC: induced pluripotent stem cells; TO: tooth organoids; DE: dental epithelium; AB: ameloblast.

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Developmental Defects of the Teeth and Their Hard Tissues

Cited by 3 publications

References 127 publications

Do hypomineralized teeth affect parents' emotional states and attitudes more than other discoloration conditions?

Do hypomineralized teeth affect parents' emotional states and attitudes more than other discoloration conditions?

Hereditary Tooth Anomalies: Amelogenesis Imperfecta, Dentinogenesis Imperfecta, Dentine Dysplasia

From Pluripotent Stem Cells to Organoids and Bioprinting: Recent Advances in Dental Epithelium and Ameloblast Models to Study Tooth Biology and Regeneration

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