Developmental Differences in Relations Between Episodic Memory and Hippocampal Subregion Volume During Early Childhood

Riggins, Tracy; Blankenship, Sarah L.; Mulligan, Elizabeth M.; Rice, Katherine; Redcay, Elizabeth

doi:10.1111/cdev.12445

Cited by 71 publications

(94 citation statements)

References 41 publications

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“…The dentate, may be more vulnerable to the adverse effects of low SES compared to other subfields, an effect otherwise obscured when testing association with the total volume of the hippocampus. Furthermore, volumes of hippocampal subfields (Bender, Daugherty & Raz, 2013) and subregions (Riggins, Blankenship, Mulligan, Rice & Redcay, 2015) show differential relation to memory across age. The relation between SES and human hippocampal subfields or subregions has yet to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Socioeconomic status and hippocampal volume in children and young adults

Daugherty

Anderson

et al. 2017

Developmental Science

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An individual's socioeconomic status (SES) is often viewed as a proxy for a host of environmental influences. SES disparities have been linked to variance in brain structures particularly the hippocampus, a neural substrate of learning and memory. However, it is unclear whether the association between SES and hippocampal volume is similar in children and adults. We investigated the relationship between hippocampal volume and SES in a group of children (n = 31, age 8-12 years) and a group of young adults (n = 32, age 18-25 years). SES was assessed with four indicators that loaded on a single factor, therefore a composite SES scores was used in the main analyses. Hippocampal volume was measured using manual demarcation on high resolution structural images. SES was associated with hippocampal volume in the children, but not in adults, suggesting that in childhood, but not adulthood, SES-related environmental factors influence hippocampal volume. In addition, hippocampal volume, but not SES, was associated with scores on a memory task, suggesting that net effects of postnatal environmental factors, captured by SES, are more distal determinants of memory performance than hippocampal volume. Longitudinal investigation of the association between SES, hippocampal volume and cognitive functioning may further our understanding of the putative neural mechanisms underlying SES-related environmental effects on cognitive development.

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Section: Discussionmentioning

confidence: 99%

Socioeconomic status and hippocampal volume in children and young adults

Daugherty

Anderson

et al. 2017

Developmental Science

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“…() and also used by Riggins et al. () based on hippocampal head, body, and tail boundaries as defined in Duvernoy, Cattin, and Risold (). Briefly, using this protocol the hippocampal head is segmented from the hippocampal body at the point where hippocampal digitations begin to smooth on the dorsal edge and the hippocampus takes on a tear‐like shape.…”

Section: Methodsmentioning

confidence: 99%

Memory and the hippocampal formation following pediatric traumatic brain injury

DeMaster¹,

Johnson²,

Juranek³

et al. 2017

Brain and Behavior

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IntroductionPrevious research indicates disruption of learning and memory in children who have experienced traumatic brain injury (TBI).ObjectiveThis research evaluates the impact of pediatric TBI on volumetric differences along the long axis of the hippocampus, a region of the brain that is critical for explicit memory.MethodsStructural brain data and behavioral measures were collected 6 weeks following TBI or extracranial injury (EI), in children aged 8–15 years and from a group of age matched typically developing controls (TDC). Total hippocampal volume and hippocampal subregion volumes corresponding to hippocampal head, body, and tail were compared across groups and were examined in relation to verbal and visual memory.ResultsGroup differences were evident such that hippocampal body volume was found to be smaller for TBI and EI groups compared to the TDC group. Analysis restricted to the TBI group indicated that hippocampal head volume was associated with severity of injury. The relation between severity of injury and hippocampal head volume is particularly important considering results from our investigation of hippocampal volume‐to‐memory performance relations indicating positive correlations between hippocampal head volume and performance on memory measures for both the TBI group and the TDC group. Significant negative correlations between hippocampal body volume and memory were evident for the TBI group but not EI or TDC groups. Correlations between memory performance and hippocampal tail volume were not significant for the TBI or TDC groups, although for the EI group, a positive correlation was found between hippocampal tail volume and memory.ConclusionTogether these results underscore an important relation between hippocampal structure and memory function during the subacute stage of recovery from pediatric TBI.

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“…Building on behavioral research in early childhood and neuroimaging studies in school‐aged children, the first study to examine links between memory and the hippocampus early in life explored relations between detailed memories and the hippocampus. The study compared 4‐ and 6‐year olds’ capacity to recall details of a past laboratory‐based event (i.e., where an object was previously encountered) and the size (i.e., volume) of subregions of the hippocampus (Riggins, Blankenship, Mulligan, Rice, & Redcay, ). Better memory was related to larger hippocampal head volume for 6‐year olds, but not for 4‐year olds.…”

Section: Evidence For Relations Between Neural Development and Memorymentioning

confidence: 99%

Empirical Evidence Supporting Neural Contributions to Episodic Memory Development in Early Childhood: Implications for Childhood Amnesia

Riggins

Canada

Botdorf

2020

Child Dev Perspectives

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Memories for events that happen early in life are fragile—they are forgotten more quickly than expected based on typical adult rates of forgetting. Although numerous factors contribute to this phenomenon, data show that one major source of change is the protracted development of neural structures related to memory. Recent empirical studies in early childhood reveal that the development of specific subdivisions of the hippocampus (i.e., the dentate gyrus) is related directly to variations in memory. Yet, the hippocampus is only one region within a larger network supporting memory. Data from young children have also shown that activation of cortical regions during memory tasks and the functional connectivity between the hippocampus and cortex relate to memory during this period. Taken together, these results suggest that protracted neural development of the hippocampus, cortex, and connections between these regions contribute to the fragility of memories early in life and may ultimately contribute to childhood amnesia.

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Developmental Differences in Relations Between Episodic Memory and Hippocampal Subregion Volume During Early Childhood

Cited by 71 publications

References 41 publications

Socioeconomic status and hippocampal volume in children and young adults

Socioeconomic status and hippocampal volume in children and young adults

Memory and the hippocampal formation following pediatric traumatic brain injury

Empirical Evidence Supporting Neural Contributions to Episodic Memory Development in Early Childhood: Implications for Childhood Amnesia

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