Developmental DSP4 effects on cortical Arc expression

Sanders, J.E.

doi:10.1016/j.neulet.2016.02.063

Cited by 2 publications

(2 citation statements)

References 47 publications

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“…The induction of Arc expression in the rat brain is controlled by NA via α 2 -adrenoreceptors in the developmental stage-dependent manner, in which the depletion of NA in the juvenile increases the Arc level and strongly decreases, in the late adolescence (Sanders, 2016).…”

Section: Similarity Between the Juvenile And Adultmentioning

confidence: 99%

“…Or, the regained plasticity in the adult is unique and not related to the ODP of the juvenile. The induction of Arc expression in the rat brain is controlled by NA via α 2 ‐adrenoreceptors in the developmental stage‐dependent manner, in which the depletion of NA in the juvenile increases the Arc level and strongly decreases, in the late adolescence (Sanders, 2016). A link between NAergic activation and immediate early genes such as Arc and Zif268 is known in the rat cortex.…”

Section: Juvenile Versus Adult Visual Cortexmentioning

confidence: 99%

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Ocular dominance plasticity: Molecular mechanisms revisited

Kasamatsu

Imamura

2020

J of Comparative Neurology

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Ocular dominance plasticity (ODP) is a type of cortical plasticity operating in visual cortex of mammals that are endowed with binocular vision based on the competition-driven disparity. Earlier, a molecular mechanism was proposed that catecholamines play an important role in the maintenance of ODP in kittens. Having survived the initial test, the hypothesis was further advanced to identify noradrenaline (NA) as a key factor that regulates ODP in the immature cortex. Later, the ODPpromoting effect of NA is extended to the adult with age-related limitations. Following the enhanced NA availability, the chain events downstream lead to the β-adrenoreceptor-induced cAMP accumulation, which in turn activates the protein kinase A. Eventually, the protein kinase translocates to the cell nucleus to activate cAMP responsive element binding protein (CREB). CREB is a cellular transcription factor that controls the transcription of various genes, underpinning neuronal plasticity and long-term memory. In the advent of molecular genetics in that various types of new tools have become available with relative ease, ODP research has lightly adopted in the rodent model the original concepts and methodologies. Here, after briefly tracing the strategic maturation of our quest, the review moves to the later development of the field, with the emphasis placed around the following issues: (a) Are we testing ODP per se? (b) What does monocular deprivation deprive of the immature cortex? (c) The critical importance of binocular competition, (d) What is the adult plasticity? (e) Excitation-Inhibition balance in local circuits, and (f) Species differences in the animal models.

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Section: Similarity Between the Juvenile And Adultmentioning

confidence: 99%

Section: Juvenile Versus Adult Visual Cortexmentioning

confidence: 99%

Ocular dominance plasticity: Molecular mechanisms revisited

Kasamatsu

Imamura

2020

J of Comparative Neurology

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The effects of locus coeruleus ablation on mouse brain volume and microstructure evaluated by high-field MRI

Knopper,

Skoven,

Eskildsen

et al. 2024

Front. Cell. Neurosci.

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The locus coeruleus (LC) produces most of the brain’s noradrenaline (NA). Among its many roles, NA is often said to be neuroprotective and important for brain upkeep. For this reason, loss of LC integrity is thought to impact brain volume and microstructure as well as plasticity broadly. LC dysfunction is also a suspected driver in the development of neurodegenerative diseases. Nevertheless, the impact of LC dysfunction on the gross structure and microstructure of normal brains is not well-studied. We employed high-field ex vivo magnetic resonance imaging (MRI) to investigate brain volumetrics and microstructure in control (CON) mice and mice with LC ablation (LCA) at two ages, representing the developing brain and the fully matured brain. These whole-brain methods are known to be capable of detecting subtle morphological changes and brain microstructural remodeling. We found mice behavior consistent with histologically confirmed LC ablation. However, MRI showed no difference between CON and LCA groups with regard to brain size, relative regional volumes, or regional microstructural indices. Our findings suggest that LC-NA is not needed for postnatal brain maturation and growth in mice. Nor is it required for maintenance in the normal adult mouse brain, as no atrophy or microstructural aberration is detected after weeks of LC dysfunction. This adds clarity to the often-encountered notion that LC-NA is important for brain “trophic support” as it shows that such effects are likely most relevant to mechanisms related to brain plasticity and neuroprotection in the (pre)diseased brain.

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Developmental DSP4 effects on cortical Arc expression

Cited by 2 publications

References 47 publications

Ocular dominance plasticity: Molecular mechanisms revisited

Ocular dominance plasticity: Molecular mechanisms revisited

The effects of locus coeruleus ablation on mouse brain volume and microstructure evaluated by high-field MRI

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