Developmental Effects of Dietary Nucleotides in Second-Generation Weaned Rats

Xu, Mingzhen; Ma, Yi; Xu, Linlin; Xu, Yu; Li, Yong

doi:10.1089/jmf.2013.2790

Cited by 6 publications

(5 citation statements)

References 27 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, there were no adverse effects up to the dose of 1.28%. 31 The 0.04% and 0.16% NTs could reverse the above markers to attenuate alcohol-induced liver injury in the present study. Inflammation is one of the vital characteristics of alcoholic hepatitis.…”

Section: Discussionsupporting

confidence: 55%

Dietary nucleotides protect against alcoholic liver injury by attenuating inflammation and regulating gut microbiota in rats

et al. 2016

Self Cite

View full text Add to dashboard Cite

Nucleotides have been reported to be effective in attenuating liver damage and regulating gut microbiota. However, the protective effect of nucleotides against alcoholic liver injury remains unknown. The present study aims to investigate whether nucleotides ameliorate alcoholic liver injury and explores the possible mechanism. Male Wistar rats were given alcohol, equivalent distilled water or an isocaloric amount of dextrose intragastrically twice daily for up to 6 weeks respectively. Two subgroups of alcohol-treated rats were fed with a nucleotide-supplemented AIN-93G rodent diet. Serum enzymes, inflammatory cytokines and microbiota composition of the caecum content were evaluated. We found that nucleotides could significantly decrease serum alanine aminotransferase and aspartate aminotransferase, plasma lipopolysaccharide and inflammatory cytokine levels. Sequencing of 16S rRNA genes revealed that nucleotide-treated rats showed a higher abundance of Firmicutes and a lower abundance of Bacteroidetes than alcohol-treated rats. Moreover, nucleotide treatment inhibited the protein expression of toll-like receptor 4, CD14 and repressed the phosphorylation of inhibitor kappa Bα and nuclear factor-κB p65 in the liver. These results suggested that nucleotides suppressed the inflammatory response and regulated gut microbiota in alcoholic liver injury. The partial inhibition of lipopolysaccharide - toll-like receptor 4-nuclear factor-κB p65 signaling in the liver may be attributed to this mechanism.

show abstract

Section: Discussionsupporting

confidence: 55%

Dietary nucleotides protect against alcoholic liver injury by attenuating inflammation and regulating gut microbiota in rats

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…For the filial part, there were no significant differences in physical or neural development landmarks between the control and NT groups. However, in previous study [17,22], NTs consumption could promote growth and development in weaned rats. It has been suggested that NTs could reduce the incidence of diarrhea, possibly by a favorable effect on the gastrointestinal microbiota, in formula-fed infants.…”

Section: Discussionmentioning

confidence: 77%

Multi-Generations Assessment of Dietary Nucleotides Consumption in Maternal Rats

Meihong¹,

Zhao²,

Xu³

et al. 2014

JFNR

Self Cite

View full text Add to dashboard Cite

This study investigated multi-generational reproductive and developmental toxicity of dietary nucleotides (NTs) during lactation in rats with the purpose of augmenting currently available safety data. Weanling rats (F0) were fed NTs at doses of 0.01%, 0.04%, 0.16%, 0.64%, and 1.28% (wt/wt for 90 days and then mated in a 1:1 pattern. The F1 generation rats were fed NTs for 90 days after weaning. The process was repeated until F3 rats were born. We measured the physical and neural development landmarks during lactation in the F3 generation and observed the signs of maternal rats during the gestation, parturition, and lactation periods. No significant differences in either physical or neural developmental landmarks were observed between the control and NT groups. No clinically adverse effects were found in the maternal rats at any point in gestation, parturition, or lactation. There were no alterations in the indicators of parturition. No significant differences were observed between controls and NT-treated rats fed four kinds of nucleotides in F0 milk on PND 21. In conclusion, NTs in doses of up to 1.28% did not cause any adverse effects in either the maternal or filial individuals.were shown non-toxicity of NTs during lactation. The NOAEL is considered to be 1.28%.

show abstract

“…The healthy development of early gut villi improves the digestion and absorption of nutrients in infants (He et al., 2020). NTs promote the development of gut villi, improve digestion and nutrient uptake, and promote weight gain in infants (Xu et al., 2013). Exogenous NTs significantly enhance gut villus proteins and the characteristic factors of mature enterocytes and enable villus development (Rodriguez‐Serrano et al., 2010).…”

Section: Effects Of Dietary Nts On Gut Development and Function In Ea...mentioning

confidence: 99%

Feeding the microbiota–gut–brain axis: Nucleotides and their role in early life

Tian

Zhao

et al. 2023

Food Frontiers

View full text Add to dashboard Cite

Nucleotides ingested from breast milk and complementary foods during infancy play a vital role in the development of the immune and nervous system, as well as the maturation of gut function, and are considered a “special dietary nutrient.” Based on the existing research progress and theoretical basis, this review takes the distribution of dietary nucleotides (NTs) in the early life (after birth to the age of 3 years) diet and the in vivo metabolism/absorption process as the starting point and expounds on its potential impact and mechanism of action on early gastrointestinal and brain development. With the understanding of gut microbiota (GM), the interaction between dietary factors and GM has become a focus of food research. It is of great significance to reexamine the biological effects of early dietary nucleotide intake on infant gut–brain development from the perspective of the GM–gut–brain axis. This paper reveals the potential relationship between the NTs–GM–gut–brain axis and provides new ideas and theories for the research and application of NTs in the field of infant nutrition.

show abstract

Developmental Effects of Dietary Nucleotides in Second-Generation Weaned Rats

Cited by 6 publications

References 27 publications

Dietary nucleotides protect against alcoholic liver injury by attenuating inflammation and regulating gut microbiota in rats

Dietary nucleotides protect against alcoholic liver injury by attenuating inflammation and regulating gut microbiota in rats

Multi-Generations Assessment of Dietary Nucleotides Consumption in Maternal Rats

Feeding the microbiota–gut–brain axis: Nucleotides and their role in early life

Contact Info

Product

Resources

About